Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0122 | 0.0196 | 0.0278 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Onchocerca volvulus | 0.0231 | 0.705 | 1 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0122 | 0.0196 | 0.0196 |
Toxoplasma gondii | cathepsin CPL | 0.0231 | 0.705 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0231 | 0.705 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0231 | 0.705 | 0.6991 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0231 | 0.705 | 0.705 |
Brugia malayi | cathepsin L-like precursor | 0.0157 | 0.2377 | 0.2224 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0231 | 0.705 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0278 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Echinococcus granulosus | cathepsin b | 0.0278 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0122 | 0.0196 | 0.0278 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2377 | 0.2377 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0119 | 0 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0231 | 0.705 | 0.6991 |
Onchocerca volvulus | 0.0231 | 0.705 | 1 | |
Onchocerca volvulus | 0.0231 | 0.705 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2377 | 0.2377 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0278 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0278 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0231 | 0.705 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0122 | 0.0196 | 0.0196 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.0196 | 0.0278 |
Onchocerca volvulus | 0.0231 | 0.705 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2377 | 0.2377 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0231 | 0.705 | 0.705 |
Echinococcus granulosus | cathepsin l1 | 0.0157 | 0.2377 | 0.2224 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0231 | 0.705 | 0.705 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0122 | 0.0196 | 0.0196 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0122 | 0.0196 | 0.0196 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0231 | 0.705 | 0.705 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0231 | 0.705 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0231 | 0.705 | 1 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0122 | 0.0196 | 0.0278 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0231 | 0.705 | 0.6991 |
Onchocerca volvulus | 0.0231 | 0.705 | 1 | |
Onchocerca volvulus | 0.0231 | 0.705 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0231 | 0.705 | 0.6991 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0231 | 0.705 | 0.705 |
Brugia malayi | Cathepsin L-like precursor | 0.0231 | 0.705 | 0.6991 |
Onchocerca volvulus | Cathepsin L homolog | 0.0231 | 0.705 | 1 |
Leishmania major | cysteine peptidase A (CPA) | 0.0231 | 0.705 | 1 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0231 | 0.705 | 0.705 |
Giardia lamblia | Cathepsin B precursor | 0.0119 | 0 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0231 | 0.705 | 0.6991 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0231 | 0.705 | 0.705 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Onchocerca volvulus | 0.0231 | 0.705 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0231 | 0.705 | 0.705 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0157 | 0.2377 | 0.2224 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0157 | 0.2377 | 0.2224 |
Echinococcus multilocularis | cathepsin b | 0.0278 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0157 | 0.2377 | 0.3371 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0231 | 0.705 | 0.705 |
Echinococcus granulosus | cathepsin l1 | 0.0231 | 0.705 | 0.6991 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0231 | 0.705 | 0.705 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0231 | 0.705 | 0.6991 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0122 | 0.0196 | 0.0196 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0278 | 1 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0231 | 0.705 | 0.6991 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.705 | 0.705 |
Loa Loa (eye worm) | hypothetical protein | 0.0278 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0278 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0231 | 0.705 | 0.6991 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0231 | 0.705 | 0.6991 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0231 | 0.705 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0122 | 0.0196 | 0.0196 |
Onchocerca volvulus | Cathepsin L homolog | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0157 | 0.2377 | 0.3371 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0157 | 0.2377 | 0.2377 |
Entamoeba histolytica | cysteine protease, putative | 0.0231 | 0.705 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0122 | 0.0196 | 0.0196 |
Brugia malayi | Cathepsin L-like precursor | 0.0231 | 0.705 | 0.6991 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Plasmodium vivax | vivapain-2 | 0.0231 | 0.705 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0231 | 0.705 | 0.705 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0231 | 0.705 | 0.6991 |
Echinococcus granulosus | cathepsin b | 0.0278 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0231 | 0.705 | 0.6991 |
Echinococcus multilocularis | cysteine protease | 0.0231 | 0.705 | 0.6991 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0231 | 0.705 | 0.6991 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0122 | 0.0196 | 0.0196 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0231 | 0.705 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0157 | 0.2377 | 0.2224 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0231 | 0.705 | 0.705 |
Giardia lamblia | Cathepsin B precursor | 0.0119 | 0 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0157 | 0.2377 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0231 | 0.705 | 1 |
Leishmania major | cathepsin L-like protease | 0.0231 | 0.705 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0157 | 0.2377 | 0.2377 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 22 mg kg-1 | Toxicity in ip dosed mouse assessed as optimum dose that providing maximum increase in life span administered qd for 1 to 5 days | ChEMBL. | 850238 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.