TDR Targets

Basic information

Technical information

TDR Targets ID: 1898079
Name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(7-methoxyt riazolo[4,5-e]pyrimidin-3-yl)oxolane-3,4-diol
MW: 283.241 | Formula: C10H13N5O5
H donors: 3 H acceptors: 7 LogP: -1.58 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1nnc2c1ncnc2OC
InChi: 1S/C10H13N5O5/c1-19-9-5-8(11-3-12-9)15(14-13-5)10-7(18)6(17)4(2-16)20-10/h3-4,6-7,10,16-18H,2H2,1H3/t4-,6-,7-,10-/m1/s1
InChiKey: KAJPRVFYQRAZFP-KQYNXXCUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(7-methoxytriazolo[4,5-e]pyrimidin-3-yl)tetrahydrofuran-3,4-diol
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(7-methoxy-3-triazolo[4,5-e]pyrimidinyl)tetrahydrofuran-3,4-diol
(2R,3R,4S,5R)-2-(7-methoxytriazolo[4,5-e]pyrimidin-3-yl)-5-methylol-tetrahydrofuran-3,4-diol
(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(7-methoxy-[1,2,3]triazolo[4,5-e]pyrimidin-3-yl)oxolane-3,4-diol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0376	0.0376
Echinococcus granulosus	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Schistosoma mansoni	axis inhibition protein axin	0.0041	0.0141	0.0141
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0042	0.0168	0.0188
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Schistosoma mansoni	z-protein (S1r protein)	0.0049	0.0376	0.0376
Echinococcus multilocularis	neuropeptide receptor	0.0305	0.7261	0.8152
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0305	0.7261	0.7261
Schistosoma mansoni	tubulin subunit beta	0.0242	0.5575	0.5575
Entamoeba histolytica	tubulin family protein	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Brugia malayi	regulator of G-protein signaling egl-10	0.0049	0.0376	0.0376
Echinococcus multilocularis	serotonin receptor	0.0305	0.7261	0.8152
Leishmania major	beta tubulin	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0042	0.0168	0.0188
Brugia malayi	ORL1-like opioid receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	RGS-3 protein	0.0041	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Schistosoma mansoni	neuropeptide F-like receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Onchocerca volvulus		0.0305	0.7261	1
Leishmania major	beta tubulin	0.0242	0.5575	1
Onchocerca volvulus		0.0305	0.7261	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0305	0.7261	0.7261
Schistosoma mansoni	opsin-like receptor	0.0305	0.7261	0.7261
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Leishmania major	beta tubulin	0.0242	0.5575	1
Onchocerca volvulus		0.0305	0.7261	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Echinococcus granulosus	expressed protein	0.0041	0.0141	0.0159
Echinococcus granulosus	fmrfamide receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0049	0.0376	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Giardia lamblia	Beta tubulin	0.0242	0.5575	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0305	0.7261	0.7261
Mycobacterium leprae	conserved hypothetical protein	0.0035	0	0.5
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0366	0.8908	0.8908
Brugia malayi	GnHR receptor homolog	0.0305	0.7261	0.7261
Echinococcus multilocularis	regulator of G protein signaling 7	0.0049	0.0376	0.0422
Loa Loa (eye worm)	PXA domain-containing protein	0.0041	0.0141	0.0141
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0305	0.7261	0.7261
Leishmania major	beta tubulin	0.0242	0.5575	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0366	0.8908	0.8908
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0305	0.7261	0.7261
Echinococcus multilocularis	serotonin receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	neuropeptide receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	BEN-1 protein	0.0242	0.5575	0.5575
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Brugia malayi	Dopamine receptor protein 2	0.0305	0.7261	0.7261
Echinococcus granulosus	G protein coupled receptor 139	0.0305	0.7261	0.8152
Loa Loa (eye worm)	tubulin beta-4 chain	0.0242	0.5575	0.5575
Brugia malayi	A-kinase anchor protein 10, precursor	0.0041	0.0141	0.0141
Brugia malayi	putative neuropeptide receptor NPR1	0.0305	0.7261	0.7261
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0141	0.0141
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0305	0.7261	0.8152
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0305	0.7261	0.8152
Brugia malayi	PXA domain containing protein	0.0041	0.0141	0.0141
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0305	0.7261	0.8152
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus multilocularis	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Echinococcus granulosus	biogenic amine 5HT receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	neuropeptide F receptor	0.0305	0.7261	0.7261
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0305	0.7261	0.8152
Schistosoma mansoni	tubulin subunit beta	0.0242	0.5575	0.5575
Brugia malayi	G-protein coupled receptor	0.0305	0.7261	0.7261
Schistosoma mansoni	axis inhibition protein axin	0.0041	0.0141	0.0141
Leishmania major	beta tubulin	0.0242	0.5575	1
Leishmania major	beta tubulin	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus multilocularis	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Schistosoma mansoni	opsin-like receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0141	0.0141
Echinococcus multilocularis	g protein coupled receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0305	0.7261	0.8152
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Schistosoma mansoni	amine GPCR	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Entamoeba histolytica	tubulin family protein	0.0242	0.5575	1
Onchocerca volvulus		0.0305	0.7261	1
Loa Loa (eye worm)	BEN-1 protein	0.0242	0.5575	0.5575
Schistosoma mansoni	opsin-like receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0141	0.0141
Schistosoma mansoni	amine GPCR	0.0305	0.7261	0.7261
Echinococcus multilocularis	regulator of G protein signaling 7	0.0049	0.0376	0.0422
Echinococcus granulosus	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0305	0.7261	0.7261
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0305	0.7261	0.7261
Echinococcus multilocularis	neuropeptide receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	neuropeptide receptor	0.0305	0.7261	0.7261
Echinococcus granulosus	sex peptide receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	somatostatin receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	tubulin beta-1 chain	0.0242	0.5575	0.5575
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0305	0.7261	0.7261
Leishmania major	beta tubulin	0.0242	0.5575	1
Brugia malayi	neuropeptide F receptor	0.0305	0.7261	0.7261
Brugia malayi	RE15519p	0.0305	0.7261	0.7261
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0305	0.7261	0.8152
Echinococcus multilocularis	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Echinococcus granulosus	regulator of G protein signaling 3	0.0041	0.0141	0.0159
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0305	0.7261	0.7261
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0305	0.7261	0.7261
Leishmania major	beta tubulin	0.0242	0.5575	1
Leishmania major	beta tubulin	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Brugia malayi	beta-tubulin, identical	0.0242	0.5575	0.5575
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Brugia malayi	larval opioid receptor	0.0305	0.7261	0.7261
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0141	0.0141
Giardia lamblia	Beta tubulin	0.0242	0.5575	0.5
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0041	0.0141	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0141	0.0253
Onchocerca volvulus		0.0305	0.7261	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0242	0.5575	0.6259
Echinococcus granulosus	allatostatin A receptor	0.0305	0.7261	0.8152
Onchocerca volvulus		0.0305	0.7261	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0305	0.7261	0.7261
Giardia lamblia	Beta tubulin	0.0242	0.5575	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0305	0.7261	0.7261
Echinococcus granulosus	neuropeptides capa receptor	0.0305	0.7261	0.8152
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0305	0.7261	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Brugia malayi	N-terminal motif family protein	0.0177	0.3818	0.3818
Loa Loa (eye worm)	beta-tubulin	0.0242	0.5575	0.5575
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0305	0.7261	0.8152
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0041	0.0141	0.0141
Trypanosoma brucei	beta tubulin	0.0242	0.5575	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0305	0.7261	0.8152
Echinococcus granulosus	regulator of G protein signaling 7	0.0049	0.0376	0.0422
Echinococcus granulosus	neuropeptides capa receptor	0.0305	0.7261	0.8152
Echinococcus granulosus	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Brugia malayi	Dopamine receptor protein 1	0.0305	0.7261	0.7261
Onchocerca volvulus		0.0305	0.7261	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0305	0.7261	0.7261
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus granulosus	hypothetical protein	0.0305	0.7261	0.8152
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Trichomonas vaginalis	tubulin beta chain, putative	0.0242	0.5575	1
Echinococcus multilocularis	fmrfamide receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	beta tubulin	0.0242	0.5575	0.6259
Brugia malayi	neuropeptide F receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0305	0.7261	0.8152
Mycobacterium ulcerans	hypothetical protein	0.0035	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	Regulator of G protein signaling 20	0.0041	0.0141	0.0159
Trypanosoma cruzi	beta tubulin, putative	0.0242	0.5575	1
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0141	0.0141
Echinococcus multilocularis	neuropeptides capa receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	neuropeptide receptor	0.0305	0.7261	0.7261
Schistosoma mansoni	neuropeptide receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	axis inhibition protein axin	0.0041	0.0141	0.0159
Schistosoma mansoni	tubulin subunit beta	0.0242	0.5575	0.5575
Echinococcus multilocularis	regulator of G protein signaling	0.0041	0.0141	0.0159
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0141	0.0253
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0141	0.0253
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0305	0.7261	0.8152
Echinococcus granulosus	serotonin receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0305	0.7261	0.8152
Echinococcus granulosus	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus granulosus	7tm_1 domain containing protein	0.0305	0.7261	0.8152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Plasmodium vivax	tubulin beta chain, putative	0.0242	0.5575	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	G-protein coupled receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	dro:myosuppressin receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	neuropeptide Y receptor	0.0305	0.7261	0.8152
Brugia malayi	hypothetical protein	0.0041	0.0141	0.0141
Schistosoma mansoni	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus multilocularis	axis inhibition protein axin	0.0041	0.0141	0.0159
Onchocerca volvulus		0.0305	0.7261	1
Schistosoma mansoni	hypothetical protein	0.0305	0.7261	0.7261
Leishmania major	beta tubulin	0.0242	0.5575	1
Mycobacterium ulcerans	lipase LipD	0.0035	0	0.5
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.5126	1
Echinococcus granulosus	beta tubulin	0.0242	0.5575	0.6259
Echinococcus granulosus	g protein coupled receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0366	0.8908	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	tubulin subunit beta	0.0242	0.5575	0.6259
Echinococcus multilocularis	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Schistosoma mansoni	amine GPCR	0.0305	0.7261	0.7261
Loa Loa (eye worm)	tubulin beta-2A chain	0.0242	0.5575	0.5575
Echinococcus multilocularis	sex peptide receptor	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Trichomonas vaginalis	tubulin gamma chain, putative	0.0242	0.5575	1
Schistosoma mansoni	regulator of G protein signaling	0.0049	0.0376	0.0376
Schistosoma mansoni	neuropeptide f receptor 76f	0.0305	0.7261	0.7261
Echinococcus multilocularis	fmrfamide receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0305	0.7261	0.7261
Onchocerca volvulus		0.0305	0.7261	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0242	0.5575	0.6259
Schistosoma mansoni	biogenic amine receptor	0.0305	0.7261	0.7261
Echinococcus granulosus	neuropeptide s receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	tubulin subunit beta	0.0242	0.5575	0.5575
Trypanosoma brucei	beta tubulin	0.0242	0.5575	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus multilocularis	neuropeptide receptor A26	0.0305	0.7261	0.8152
Leishmania major	beta tubulin	0.0242	0.5575	1
Onchocerca volvulus		0.0305	0.7261	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Brugia malayi	AKH receptor	0.0305	0.7261	0.7261
Plasmodium falciparum	tubulin beta chain	0.0242	0.5575	0.5
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0141	0.0141
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0305	0.7261	0.7261
Echinococcus granulosus	7TM GPCR rhodopsin	0.0305	0.7261	0.8152
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	regulator of G protein signaling 3	0.0041	0.0141	0.0159
Echinococcus multilocularis	g protein coupled receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0305	0.7261	0.7261
Onchocerca volvulus		0.0305	0.7261	1
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0041	0.0141	0.0253
Mycobacterium leprae	Probable lipase LipE	0.0035	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus granulosus	neuropeptide receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0305	0.7261	0.8152
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0406	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	expressed protein	0.0041	0.0141	0.0159
Schistosoma mansoni	myosin xvIII	0.0305	0.7261	0.7261
Echinococcus multilocularis	regulator of G protein signaling 3	0.0041	0.0141	0.0159
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0041	0.0141	0.0159
Echinococcus granulosus	orexin receptor type 2	0.0305	0.7261	0.8152
Brugia malayi	putative neuropeptide receptor	0.0305	0.7261	0.7261
Brugia malayi	Tubulin beta-1 chain	0.0242	0.5575	0.5575
Echinococcus granulosus	tubulin subunit beta	0.0242	0.5575	0.6259
Brugia malayi	G protein-coupled receptor	0.0305	0.7261	0.7261
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	beta tubulin	0.0242	0.5575	0.6259
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Brugia malayi	follicle stimulating hormone receptor	0.0305	0.7261	0.7261
Brugia malayi	sulfakinin receptor protein	0.0305	0.7261	0.7261
Onchocerca volvulus		0.0305	0.7261	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0041	0.0141	0.0141
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0141	0.0253
Brugia malayi	regulator of G-protein signaling rgs-7	0.0041	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Onchocerca volvulus		0.0305	0.7261	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	melatonin receptor type 1A	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0305	0.7261	0.8152
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	g protein coupled receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	biogenic amine receptor	0.0305	0.7261	0.7261
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0305	0.7261	0.7261
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0141	0.0253
Echinococcus granulosus	tm gpcr rhodopsin	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0141	0.0141
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0305	0.7261	0.7261
Brugia malayi	G protein-coupled receptor F59B2.13	0.0305	0.7261	0.7261
Brugia malayi	Serotonin receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0041	0.0141	0.0159
Echinococcus granulosus	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Schistosoma mansoni	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus multilocularis	G protein coupled receptor 139	0.0305	0.7261	0.8152
Schistosoma mansoni	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	tubulin beta 4A class IVa	0.0242	0.5575	0.6259
Echinococcus granulosus	g-protein coupled receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Echinococcus granulosus	regulator of G protein signaling 3	0.0041	0.0141	0.0159
Echinococcus granulosus	g protein coupled receptor	0.0305	0.7261	0.8152
Echinococcus granulosus	neuropeptide receptor	0.0305	0.7261	0.8152
Schistosoma mansoni	adenoreceptor	0.0305	0.7261	0.7261
Mycobacterium ulcerans	beta-lactamase	0.0035	0	0.5
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Onchocerca volvulus		0.0305	0.7261	1
Onchocerca volvulus		0.0305	0.7261	1
Echinococcus multilocularis	allatostatin A receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0305	0.7261	0.8152
Echinococcus granulosus	tm gpcr rhodopsin	0.0305	0.7261	0.8152
Toxoplasma gondii	beta tubulin	0.0242	0.5575	1
Loa Loa (eye worm)	TYRA-2 protein	0.0305	0.7261	0.7261
Echinococcus multilocularis	beta tubulin	0.0242	0.5575	0.6259
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0041	0.0141	0.0141
Loa Loa (eye worm)	hypothetical protein	0.0177	0.3818	0.3818
Onchocerca volvulus		0.0305	0.7261	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0305	0.7261	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Echinococcus granulosus	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus granulosus	g protein coupled receptor	0.0305	0.7261	0.8152
Leishmania major	beta tubulin	0.0242	0.5575	1
Echinococcus granulosus	axis inhibition protein axin	0.0041	0.0141	0.0159
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	tubulin beta 1 chain	0.0242	0.5575	0.6259
Echinococcus multilocularis	neuropeptides capa receptor	0.0305	0.7261	0.8152
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	tm gpcr rhodopsin	0.0305	0.7261	0.8152
Trichomonas vaginalis	tubulin alpha chain, putative	0.0242	0.5575	1
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0366	0.8908	0.8908
Echinococcus granulosus	regulator of G protein signaling 7	0.0049	0.0376	0.0422
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Schistosoma mansoni	histamine h1 receptor	0.0305	0.7261	0.7261
Leishmania major	beta tubulin	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Schistosoma mansoni	amine GPCR	0.0305	0.7261	0.7261
Schistosoma mansoni	biogenic amine receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	Tubulin beta 2C chain	0.0242	0.5575	0.6259
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0168	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0305	0.7261	0.7261
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0305	0.7261	0.7261
Leishmania major	beta tubulin	0.0242	0.5575	1
Brugia malayi	G-protein coupled receptor	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Trypanosoma brucei	beta tubulin	0.0242	0.5575	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0305	0.7261	0.7261
Schistosoma mansoni	amine GPCR	0.0305	0.7261	0.7261
Echinococcus granulosus	neuropeptide receptor A26	0.0305	0.7261	0.8152
Schistosoma mansoni	serine/threonine protein kinase	0.0406	1	1
Echinococcus granulosus	axis inhibition protein axin	0.0041	0.0141	0.0159
Echinococcus granulosus	neuropeptide Y receptor	0.0305	0.7261	0.8152
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0041	0.0141	0.0141
Schistosoma mansoni	regulator of G protein signaling	0.0041	0.0141	0.0141
Schistosoma mansoni	neuropeptide F-like receptor	0.0305	0.7261	0.7261
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0305	0.7261	0.8152
Brugia malayi	hypothetical protein	0.0041	0.0141	0.0141
Schistosoma mansoni	tubulin subunit beta	0.0242	0.5575	0.5575
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0141	0.0253
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0	0.5
Echinococcus granulosus	somatostatin receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	neuropeptide Y receptor	0.0305	0.7261	0.8152
Onchocerca volvulus		0.0305	0.7261	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0305	0.7261	0.8152
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0305	0.7261	0.8152
Echinococcus multilocularis	neuropeptide s receptor	0.0305	0.7261	0.8152
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	neuropeptide Y receptor	0.0305	0.7261	0.8152
Toxoplasma gondii	beta-tubulin, putative	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Trichomonas vaginalis	tubulin, putative	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	dro:myosuppressin receptor	0.0305	0.7261	0.8152
Toxoplasma gondii	beta-1 tubulin, putative	0.0242	0.5575	1
Brugia malayi	PXA domain containing protein	0.0041	0.0141	0.0141
Loa Loa (eye worm)	G-protein coupled receptor	0.0305	0.7261	0.7261
Leishmania major	beta tubulin	0.0242	0.5575	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0141	0.0141
Loa Loa (eye worm)	tubulin beta chain	0.0242	0.5575	0.5575
Brugia malayi	Serotonin receptor	0.0305	0.7261	0.7261
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0177	0.3818	0.5258
Loa Loa (eye worm)	hypothetical protein	0.0305	0.7261	0.7261
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0366	0.8908	1
Brugia malayi	hypothetical protein	0.0305	0.7261	0.7261
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0042	0.0168	0.0168
Leishmania major	beta tubulin	0.0242	0.5575	1
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0041	0.0141	0.0141
Leishmania major	beta tubulin	0.0242	0.5575	1
Trypanosoma brucei	beta tubulin	0.0242	0.5575	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0305	0.7261	0.8152
Echinococcus multilocularis	g-protein coupled receptor	0.0305	0.7261	0.8152
Brugia malayi	Melatonin receptor type 1A	0.0305	0.7261	0.7261
Schistosoma mansoni	tubulin subunit beta	0.0242	0.5575	0.5575
Schistosoma mansoni	serine/threonine protein kinase	0.0042	0.0168	0.0168
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0305	0.7261	0.7261
Echinococcus multilocularis	orexin receptor type 2	0.0305	0.7261	0.8152
Leishmania major	beta tubulin	0.0242	0.5575	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0	0.5
Brugia malayi	Dopamine receptor	0.0305	0.7261	0.7261

Activities

Activity type	Activity value	Assay description	Source	Reference
ILS (functional)	= 29 %	Antitumor activity against mouse L1210 cells allografted in ip dosed BD2F1 mouse assessed as increase in life span administered 1 to 9 days measured on day 10 to 12 relative to control	ChEMBL.	556773
Km (binding)	= 140 uM	Kinetic parameter in calf intestine adenosine deaminase.	ChEMBL.	6620307

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3244702

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1898079