Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | proteasome (prosome, macropain) subunit, beta type, 5 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | proteasome subunit alpha type-5, putative | proteasome (prosome, macropain) subunit, beta type, 5 | 160 aa | 148 aa | 23.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0086 | 0 | 0.5 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0086 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0222 | 0.4793 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.363 | 0.363 |
Mycobacterium ulcerans | proteasome PrcB | 0.0086 | 0 | 0.5 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0086 | 0 | 0.5 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0086 | 0 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0222 | 0.4793 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0222 | 0.4793 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.037 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.037 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0086 | 0 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0222 | 0.4793 | 0.4793 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.037 | 1 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0086 | 0 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0086 | 0 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0222 | 0.4793 | 0.4793 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0086 | 0 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0222 | 0.4793 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of trypsin-like activity of 20S proteasome in human erythrocytes using Boc-Leu-Arg-Arg-AMC as substrate by fluorescence assay | ChEMBL. | 24946214 | |
Inhibition (binding) | = 44 % | Inhibition of PGPH-like activity of 20S proteasome in human erythrocytes using Z-Leu-Leu-Glu-AMC as substrate at 20 uM by fluorescence assay relative to control | ChEMBL. | 24946214 |
Ki (binding) | Inhibition of bovine pancreatic alpha-chymotrypsin using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay | ChEMBL. | 24946214 | |
Ki (binding) | = 0.08 uM | Inhibition of chymotrypsin-like activity of 20S proteasome in human erythrocytes using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence assay | ChEMBL. | 24946214 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.