Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0175 | 0.227 | 0.227 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Schistosoma mansoni | choline o-acyltransferase | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0298 | 0.5176 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0175 | 0.227 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5176 | 1 |
Echinococcus multilocularis | jun protein | 0.0094 | 0.0358 | 0.0692 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0297 | 0.0297 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0175 | 0.227 | 0.4385 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0094 | 0.0358 | 0.0692 |
Schistosoma mansoni | choline o-acyltransferase | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0175 | 0.227 | 0.4385 |
Brugia malayi | bZIP transcription factor family protein | 0.0094 | 0.0358 | 0.0358 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0175 | 0.227 | 0.4385 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0175 | 0.227 | 0.4385 |
Echinococcus granulosus | jun protein | 0.0094 | 0.0358 | 0.0692 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0094 | 0.0358 | 0.0692 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0298 | 0.5176 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0298 | 0.5176 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0298 | 0.5176 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0175 | 0.227 | 0.227 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0865 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 0.6639 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | = 47.5582 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.