Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Carnitine palmitoyltransferase 1A | Starlite/ChEMBL | No references |
Homo sapiens | carnitine palmitoyltransferase 1A (liver) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Onchocerca volvulus | Carnitine palmitoyltransferase 1A | 773 aa | 758 aa | 43.8 % | |
Candida albicans | similar to S. cerevisiae YAT2 putative carnitine O-acetyltransferase | Carnitine palmitoyltransferase 1A | 773 aa | 645 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0471 | 0.0471 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0244 | 0.3943 | 0.3643 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Schistosoma mansoni | hypothetical protein | 0.0244 | 0.3943 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0269 | 0.4587 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0244 | 0.3943 | 0.3943 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.4587 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0269 | 0.4587 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0471 | 0.0471 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0269 | 0.4587 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0473 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0471 | 0.0471 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0269 | 0.4587 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0113 | 0.0471 | 0.1027 |
Onchocerca volvulus | 0.0244 | 0.3943 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1094 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, liver isoform | ChEMBL. | No reference |
IC50 (binding) | = 0.8154 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 1, muscle isoform | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY: Inhibition of Carnitine palmitoyltransferase 2 | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | SUPPLEMENTARY | SUPPLEMENTARY. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.