Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Homo sapiens | TTK protein kinase | Starlite/ChEMBL | References |
Homo sapiens | aurora kinase A | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Onchocerca volvulus | 0.0167 | 0.9096 | 0.9763 | |
Brugia malayi | Protein kinase domain containing protein | 0.0088 | 0.4609 | 0.4609 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0069 | 0.353 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0088 | 0.4609 | 1 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.043 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0638 | 0.0638 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0069 | 0.353 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0069 | 0.353 | 0.353 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0267 | 0.058 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0069 | 0.353 | 0.353 |
Entamoeba histolytica | protein kinase, putative | 0.0069 | 0.353 | 0.5 |
Schistosoma mansoni | nephrin | 0.0014 | 0.043 | 0.0933 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0069 | 0.353 | 0.7659 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | AUR protein kinase | 0.0069 | 0.353 | 0.353 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0088 | 0.4609 | 1 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0088 | 0.4609 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0638 | 0.1385 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0069 | 0.353 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0475 | 0.0475 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.9317 | 1 |
Leishmania major | protein kinase, putative | 0.0069 | 0.353 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0058 | 0.0126 |
Echinococcus granulosus | defective proboscis extension response | 0.0011 | 0.0267 | 0.058 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0088 | 0.4609 | 0.4947 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0069 | 0.353 | 0.353 |
Schistosoma mansoni | protein kinase | 0.0069 | 0.353 | 0.7659 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0069 | 0.353 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0069 | 0.353 | 0.7659 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0638 | 0.1385 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0011 | 0.0267 | 0.0267 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0475 | 0.1031 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0475 | 0.1031 |
Toxoplasma gondii | aurora kinase | 0.0069 | 0.353 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0069 | 0.353 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.043 | 0.0933 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0088 | 0.4609 | 1 |
Loa Loa (eye worm) | CAMK/MLCK protein kinase | 0.0008 | 0.0063 | 0.0063 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0069 | 0.353 | 0.5 |
Entamoeba histolytica | protein kinase , putative | 0.0069 | 0.353 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0011 | 0.0267 | 0.058 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Echinococcus granulosus | Immunoglobulin | 0.0011 | 0.0267 | 0.058 |
Trypanosoma brucei | aurora B kinase | 0.0069 | 0.353 | 0.5 |
Echinococcus granulosus | aurora kinase A | 0.0069 | 0.353 | 0.7659 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0011 | 0.0267 | 0.0267 |
Brugia malayi | serine/threonine kinase 12 | 0.0069 | 0.353 | 0.353 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0267 | 0.0267 |
Loa Loa (eye worm) | AUR protein kinase | 0.0069 | 0.353 | 0.353 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0267 | 0.058 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0638 | 0.0638 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0267 | 0.058 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0069 | 0.353 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0267 | 0.058 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.353 | 0.7659 |
Giardia lamblia | Kinase, TTK | 0.0088 | 0.4609 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0069 | 0.353 | 0.5 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0011 | 0.0267 | 0.058 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0088 | 0.4609 | 1 |
Echinococcus multilocularis | aurora kinase A | 0.0069 | 0.353 | 0.7659 |
Loa Loa (eye worm) | TTK protein kinase | 0.0088 | 0.4609 | 0.4609 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0493 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.44 uM | Cytotoxicity against human MDA-MB-468 cells after 5 days by sulforhodamine B assay | ChEMBL. | 25763473 |
IC50 (binding) | Inhibition of AURKB/INCENP (unknown origin) preincubated for 15 mins prior to ATP addition by FRET-based homogenous assay | ChEMBL. | 25763473 | |
IC50 (binding) | = 0.012 uM | Inhibition of amino terminal GST-fused full length human TTK using His6-SUMO-TTK-N as substrate preincubated for 15 mins prior to ATP addition by indirect ELISA detection system | ChEMBL. | 25763473 |
IC50 (binding) | = 1.2 uM | Inhibition of recombinant KDR (unknown origin) preincubated for 15 mins prior to ATP addition by FRET-based homogenous assay | ChEMBL. | 25763473 |
IC50 (binding) | = 2.1 uM | Inhibition of recombinant AURKA (unknown origin) preincubated for 15 mins prior to ATP addition by FRET-based homogenous assay | ChEMBL. | 25763473 |
T1/2 (ADMET) | = 5.8 min | Half life in mouse liver microsomes at 1 uM by LC-MS analysis | ChEMBL. | 25763473 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.