Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.2045 | 0.3131 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Trypanosoma brucei | unspecified product | 0.0533 | 0.0769 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0284 | 0.0908 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0092 | 0.008 | 0.0248 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0026 | 0.0082 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0083 | 0.0066 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0026 | 0.0082 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0491 | 0.0703 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0199 | 0.0614 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0002 | 0.0006 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Trypanosoma brucei | ribonuclease H1 | 0.0491 | 0.0703 | 0.0702 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | integrin alpha-ps | 0.0048 | 0.0011 | 0.0037 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0092 | 0.008 | 0.0256 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | Pax transcription factor protein 2 | 0.0213 | 0.027 | 0.3835 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Echinococcus granulosus | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Loa Loa (eye worm) | integrin beta-2 | 0.028 | 0.0374 | 0.1156 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Giardia lamblia | Ribonuclease H | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0213 | 0.027 | 0.0834 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0006 | 0.0018 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0316 | 0.043 | 0.1373 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Leishmania major | ribonuclease H1, putative | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | protein kinase | 0.0042 | 0.0002 | 0.0006 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0085 | 0.007 | 0.0989 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0026 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Toxoplasma gondii | hypothetical protein | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1841 | 0.2812 | 0.898 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Echinococcus multilocularis | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | KRAB A domain containing protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0168 | 0.0199 | 0.2823 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2112 | 0.3235 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0316 | 0.043 | 0.611 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.0026 | 0.0375 |
Brugia malayi | Integrin beta pat-3 precursor | 0.028 | 0.0374 | 0.5317 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | integrin alpha-4 | 0.0393 | 0.0551 | 0.1759 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0092 | 0.008 | 0.1141 |
Echinococcus multilocularis | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Onchocerca volvulus | 0.0213 | 0.027 | 0.3819 | |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0044 | 0.0006 | 0.0078 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Onchocerca volvulus | 0.0042 | 0.0002 | 0.0002 | |
Mycobacterium tuberculosis | Possible maturase | 0.0042 | 0.0002 | 0.5 |
Echinococcus granulosus | geminin | 0.015 | 0.0171 | 0.2434 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2045 | 0.3131 | 1 |
Echinococcus granulosus | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | geminin | 0.015 | 0.0171 | 0.2434 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.043 | 0.1329 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Echinococcus multilocularis | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | integrin alpha | 0.0092 | 0.008 | 0.0256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.