Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | protein kinase | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0085 | 0.007 | 0.0989 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0316 | 0.043 | 0.1373 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Leishmania major | ribonuclease H1, putative | 0.0491 | 0.0703 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus granulosus | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0213 | 0.027 | 0.0834 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0006 | 0.0018 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Giardia lamblia | Ribonuclease H | 0.0491 | 0.0703 | 1 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0028 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0092 | 0.008 | 0.0256 |
Brugia malayi | Pax transcription factor protein 2 | 0.0213 | 0.027 | 0.3835 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0491 | 0.0703 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0491 | 0.0703 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.028 | 0.0374 | 0.1156 |
Echinococcus granulosus | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0026 | 0.0082 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0199 | 0.0614 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0491 | 0.0703 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | ribonuclease H1 | 0.0491 | 0.0703 | 0.0702 |
Schistosoma mansoni | integrin alpha-ps | 0.0048 | 0.0011 | 0.0037 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0002 | 0.0006 |
Trypanosoma brucei | unspecified product | 0.0533 | 0.0769 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0092 | 0.008 | 0.0248 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0284 | 0.0908 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0083 | 0.0066 | 0.0934 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0026 | 0.0082 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.2045 | 0.3131 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.043 | 0.1329 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Schistosoma mansoni | integrin alpha | 0.0092 | 0.008 | 0.0256 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2045 | 0.3131 | 1 |
Echinococcus multilocularis | geminin | 0.015 | 0.0171 | 0.2434 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0533 | 0.0769 | 0.0767 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0042 | 0.0002 | 0.0026 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Onchocerca volvulus | 0.0042 | 0.0002 | 0.0002 | |
Echinococcus granulosus | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | geminin | 0.015 | 0.0171 | 0.2434 |
Mycobacterium tuberculosis | Possible maturase | 0.0042 | 0.0002 | 0.5 |
Schistosoma mansoni | integrin alpha-4 | 0.0393 | 0.0551 | 0.1759 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0092 | 0.008 | 0.1141 |
Echinococcus multilocularis | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Onchocerca volvulus | 0.0213 | 0.027 | 0.3819 | |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0044 | 0.0006 | 0.0078 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0168 | 0.0199 | 0.2823 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0316 | 0.043 | 0.611 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0042 | 0.0002 | 0.0006 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.0026 | 0.0375 |
Brugia malayi | Integrin beta pat-3 precursor | 0.028 | 0.0374 | 0.5317 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Echinococcus multilocularis | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | KRAB A domain containing protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0026 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Schistosoma mansoni | hypothetical protein | 0.1841 | 0.2812 | 0.898 |
Toxoplasma gondii | hypothetical protein | 0.2112 | 0.3235 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 225 uM | Cytotoxicity against human A549 cells after 48 hrs by MTT assay | ChEMBL. | 25780985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.