Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Giardia lamblia | Ribonuclease H | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0213 | 0.027 | 0.0834 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0006 | 0.0018 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0316 | 0.043 | 0.1373 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Leishmania major | ribonuclease H1, putative | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | protein kinase | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0085 | 0.007 | 0.0989 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.2045 | 0.3131 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Trypanosoma brucei | unspecified product | 0.0533 | 0.0769 | 0.0767 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0092 | 0.008 | 0.0248 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0284 | 0.0908 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0026 | 0.0082 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0083 | 0.0066 | 0.0934 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0026 | 0.0082 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0199 | 0.0614 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0491 | 0.0703 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0533 | 0.0769 | 0.0767 |
Trypanosoma brucei | ribonuclease H1 | 0.0491 | 0.0703 | 0.0702 |
Schistosoma mansoni | integrin alpha-ps | 0.0048 | 0.0011 | 0.0037 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0002 | 0.0006 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0092 | 0.008 | 0.0256 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | Pax transcription factor protein 2 | 0.0213 | 0.027 | 0.3835 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | integrin beta-2 | 0.028 | 0.0374 | 0.1156 |
Echinococcus granulosus | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Onchocerca volvulus | 0.0042 | 0.0002 | 0.0002 | |
Echinococcus granulosus | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Mycobacterium tuberculosis | Possible maturase | 0.0042 | 0.0002 | 0.5 |
Echinococcus granulosus | geminin | 0.015 | 0.0171 | 0.2434 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2045 | 0.3131 | 1 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | geminin | 0.015 | 0.0171 | 0.2434 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.043 | 0.1329 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Schistosoma mansoni | integrin alpha | 0.0092 | 0.008 | 0.0256 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0026 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Schistosoma mansoni | hypothetical protein | 0.1841 | 0.2812 | 0.898 |
Toxoplasma gondii | hypothetical protein | 0.2112 | 0.3235 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Echinococcus multilocularis | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | KRAB A domain containing protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0316 | 0.043 | 0.611 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0168 | 0.0199 | 0.2823 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0042 | 0.0002 | 0.0006 |
Brugia malayi | Integrin beta pat-3 precursor | 0.028 | 0.0374 | 0.5317 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.0026 | 0.0375 |
Schistosoma mansoni | integrin alpha-4 | 0.0393 | 0.0551 | 0.1759 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0092 | 0.008 | 0.1141 |
Echinococcus multilocularis | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Onchocerca volvulus | 0.0213 | 0.027 | 0.3819 | |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0044 | 0.0006 | 0.0078 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.