Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Saccharomyces cerevisiae | histone acetyltransferase GCN5 | Starlite/ChEMBL | References |
Saccharomyces cerevisiae | Rtt109p | Starlite/ChEMBL | References |
Homo sapiens | E1A binding protein p300 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | CREB binding protein | 0.0197 | 0.8215 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0235 | 1 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0235 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0071 | 0.2354 | 0.2354 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0235 | 1 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0071 | 0.2354 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.0189 | 0.7822 | 0.7822 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0071 | 0.2354 | 0.2865 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0063 | 0.1989 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0062 | 0.195 | 0.195 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0071 | 0.2354 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0071 | 0.2354 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0071 | 0.2354 | 0.0946 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0063 | 0.1989 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0071 | 0.2354 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0063 | 0.1989 | 0.5 |
Loa Loa (eye worm) | CBP-B | 0.0198 | 0.8264 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0071 | 0.2354 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K27 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay | ChEMBL. | 25634295 | |
Activity (binding) | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | ChEMBL. | 25634295 | |
Activity (binding) | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 assessed as H3K56 acetylated product at 125 uM after 45 mins by Slot bolt inhibiton assay | ChEMBL. | 25634295 | |
Activity (binding) | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting in presence of 1 mM DTT | ChEMBL. | 25634295 | |
IC50 (binding) | = 0.77 uM | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | ChEMBL. | 25634295 |
IC50 (binding) | = 1.1 uM | Inhibition of recombinant histone acetyltransferase p300 (unknown origin) using dH3-H4 tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | ChEMBL. | 25634295 |
IC50 (binding) | = 1.6 uM | Inhibition of yeast histone acetyltransferase Gcn5-Ada2-Ada3 complex using tetramer and [3H]-acetyl-CoA assessed as acetate incorporation after 30 mins by liquid scintillation counting | ChEMBL. | 25634295 |
IC50 (binding) | = 2.3 uM | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CPM based HTS assay | ChEMBL. | 25634295 |
IC50 (binding) | = 5.8 uM | Inhibition of Vps75-stimulated recombinant Saccharomyces cerevisiae histone acetyltransferase Rtt109 using Asf1-dH3-H4 as substrate assessed as coenzyme A production after 45 mins by CoA-based HTS counter screen assay | ChEMBL. | 25634295 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.