Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Giardia lamblia | Ribonuclease H | 0.0491 | 0.0703 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0006 | 0.0018 |
Echinococcus granulosus | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0213 | 0.027 | 0.0834 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Leishmania major | ribonuclease H1, putative | 0.0491 | 0.0703 | 0.5 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0316 | 0.043 | 0.1373 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0085 | 0.007 | 0.0989 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Schistosoma mansoni | protein kinase | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.2045 | 0.3131 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0026 | 0.0082 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0083 | 0.0066 | 0.0934 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0092 | 0.008 | 0.0248 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0284 | 0.0908 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | unspecified product | 0.0533 | 0.0769 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0533 | 0.0769 | 0.0767 |
Trypanosoma brucei | ribonuclease H1 | 0.0491 | 0.0703 | 0.0702 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Schistosoma mansoni | integrin alpha-ps | 0.0048 | 0.0011 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0002 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0199 | 0.0614 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0491 | 0.0703 | 1 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0026 | 0.0082 |
Loa Loa (eye worm) | integrin beta-2 | 0.028 | 0.0374 | 0.1156 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0491 | 0.0703 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | Pax transcription factor protein 2 | 0.0213 | 0.027 | 0.3835 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | integrin alpha-ps | 0.0092 | 0.008 | 0.0256 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0028 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Mycobacterium tuberculosis | Possible maturase | 0.0042 | 0.0002 | 0.5 |
Echinococcus granulosus | geminin | 0.015 | 0.0171 | 0.2434 |
Echinococcus granulosus | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Onchocerca volvulus | 0.0042 | 0.0002 | 0.0002 | |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Echinococcus multilocularis | geminin | 0.015 | 0.0171 | 0.2434 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2045 | 0.3131 | 1 |
Schistosoma mansoni | integrin alpha | 0.0092 | 0.008 | 0.0256 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.043 | 0.1329 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Schistosoma mansoni | hypothetical protein | 0.1841 | 0.2812 | 0.898 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Toxoplasma gondii | hypothetical protein | 0.2112 | 0.3235 | 1 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0026 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | KRAB A domain containing protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0042 | 0.0002 | 0.0006 |
Brugia malayi | Integrin beta pat-3 precursor | 0.028 | 0.0374 | 0.5317 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.0026 | 0.0375 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2112 | 0.3235 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0316 | 0.043 | 0.611 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0168 | 0.0199 | 0.2823 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0044 | 0.0006 | 0.0078 |
Onchocerca volvulus | 0.0213 | 0.027 | 0.3819 | |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0092 | 0.008 | 0.1141 |
Echinococcus multilocularis | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Schistosoma mansoni | integrin alpha-4 | 0.0393 | 0.0551 | 0.1759 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.