Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Schistosoma mansoni | integrin alpha | 0.0092 | 0.008 | 0.0256 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | dopamine-beta-monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 0.043 | 0.1329 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Echinococcus multilocularis | geminin | 0.015 | 0.0171 | 0.2434 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Echinococcus granulosus | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | 0.2045 | 0.3131 | 1 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0533 | 0.0769 | 0.0767 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Echinococcus granulosus | geminin | 0.015 | 0.0171 | 0.2434 |
Mycobacterium tuberculosis | Possible maturase | 0.0042 | 0.0002 | 0.5 |
Echinococcus granulosus | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Onchocerca volvulus | 0.0042 | 0.0002 | 0.0002 | |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Echinococcus granulosus | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0044 | 0.0006 | 0.0078 |
Onchocerca volvulus | 0.0213 | 0.027 | 0.3819 | |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | integrin alpha 3 | 0.0044 | 0.0006 | 0.0078 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0092 | 0.008 | 0.1141 |
Schistosoma mansoni | integrin alpha-4 | 0.0393 | 0.0551 | 0.1759 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | scy1(yeast) protein kinase-like | 0.0042 | 0.0002 | 0.0006 |
Brugia malayi | Kelch motif family protein | 0.0057 | 0.0026 | 0.0375 |
Brugia malayi | Integrin beta pat-3 precursor | 0.028 | 0.0374 | 0.5317 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2112 | 0.3235 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0168 | 0.0199 | 0.2823 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0316 | 0.043 | 0.611 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Echinococcus granulosus | KRAB A domain containing protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | ribonuclease H1 | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.015 | 0.0171 | 0.0547 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0002 | 0.0006 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0491 | 0.0703 | 1 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | hypothetical protein | 0.1841 | 0.2812 | 0.898 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Toxoplasma gondii | hypothetical protein | 0.2112 | 0.3235 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Brugia malayi | hypothetical protein | 0.0057 | 0.0026 | 0.0375 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein | 0.0085 | 0.007 | 0.0989 |
Echinococcus multilocularis | peptidyl glycine alpha amidating monooxygenase | 0.0316 | 0.043 | 0.611 |
Schistosoma mansoni | protein kinase | 0.0042 | 0.0002 | 0.0006 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0533 | 0.0769 | 0.0767 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Leishmania major | ribonuclease H1, putative | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | phosphoglucomutase | 0.0491 | 0.0703 | 0.2246 |
Brugia malayi | Zinc knuckle family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0006 | 0.0017 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | peptidyl-glycine monooxygenase | 0.0316 | 0.043 | 0.1373 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | hypothetical protein | 0.0044 | 0.0006 | 0.0018 |
Echinococcus multilocularis | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Loa Loa (eye worm) | pax transcription factor protein 2 | 0.0213 | 0.027 | 0.0834 |
Echinococcus granulosus | integrin alpha ps | 0.0044 | 0.0006 | 0.0078 |
Giardia lamblia | Ribonuclease H | 0.0491 | 0.0703 | 1 |
Brugia malayi | reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | integrin beta-2 | 0.028 | 0.0374 | 0.1156 |
Echinococcus granulosus | integrin alpha ps | 0.0092 | 0.008 | 0.1141 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Wolbachia endosymbiont of Brugia malayi | ribonuclease HI | 0.0491 | 0.0703 | 0.5 |
Treponema pallidum | ribonuclease H (rnhA) | 0.0491 | 0.0703 | 0.5 |
Brugia malayi | Pax transcription factor protein 2 | 0.0213 | 0.027 | 0.3835 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0026 |
Brugia malayi | RNase H family protein | 0.0491 | 0.0703 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0092 | 0.008 | 0.0256 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0374 | 0.5317 |
Loa Loa (eye worm) | hypothetical protein | 0.2112 | 0.3235 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0028 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0533 | 0.0769 | 0.0767 |
Trypanosoma brucei | ribonuclease H1 | 0.0491 | 0.0703 | 0.0702 |
Schistosoma mansoni | integrin alpha-ps | 0.0048 | 0.0011 | 0.0037 |
Schistosoma mansoni | peptidylglycine monooxygenase | 0.0168 | 0.0199 | 0.0634 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0042 | 0.0002 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.0199 | 0.0614 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0002 | 0.0026 |
Onchocerca volvulus | Ribonuclease H1 homolog | 0.0491 | 0.0703 | 1 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0026 | 0.0082 |
Brugia malayi | Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein | 0.0083 | 0.0066 | 0.0934 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0057 | 0.0026 | 0.0082 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0092 | 0.008 | 0.0248 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0026 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0.0284 | 0.0908 |
Echinococcus granulosus | RNA directed DNA polymerase reverse transcriptase | 0.0042 | 0.0002 | 0.0026 |
Trypanosoma brucei | unspecified product | 0.0533 | 0.0769 | 0.0767 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0011 | 0.0035 |
Brugia malayi | Pao retrotransposon peptidase family protein | 0.0042 | 0.0002 | 0.0028 |
Echinococcus multilocularis | RNA directed DNA polymerase (reverse transcriptase) | 0.0042 | 0.0002 | 0.0028 |
Schistosoma mansoni | family A2 unassigned peptidase (A02 family) | 0.2045 | 0.3131 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.