Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.0121 | 0.0152 |
Schistosoma mansoni | immunophilin | 0.0056 | 0.0469 | 0.0351 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0056 | 0.0469 | 0.5 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0404 | 0.0505 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0056 | 0.0469 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 0.2692 | 0.2602 |
Loa Loa (eye worm) | subtilase | 0.0267 | 0.476 | 0.5955 |
Brugia malayi | Subtilase family protein | 0.0267 | 0.476 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.2692 | 0.2456 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0282 | 0.0353 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.7994 | 1 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0055 | 0.0452 | 0.0144 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0056 | 0.0469 | 0.0161 |
Loa Loa (eye worm) | FKBP5 protein | 0.0056 | 0.0469 | 0.0586 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.0469 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.7994 | 1 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0056 | 0.0469 | 0.0351 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0056 | 0.0469 | 0.5 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0048 | 0.0312 | 0.0193 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0525 | 1 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0056 | 0.0469 | 0.0149 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0452 | 0.0335 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0056 | 0.0469 | 0.0149 |
Trichomonas vaginalis | immunophilin, putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0056 | 0.0469 | 0.0586 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0452 | 0.0314 |
Echinococcus multilocularis | Peptidase S8 S53, subtilisin kexin sedolisin | 0.01 | 0.1365 | 0.1259 |
Schistosoma mansoni | tripeptidyl-peptidase II (S08 family) | 0.0267 | 0.476 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Echinococcus granulosus | calpain A | 0.0055 | 0.0452 | 0.0144 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0121 | 0.0152 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2692 | 0.5349 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0056 | 0.0469 | 0.0351 |
Echinococcus multilocularis | calpain A | 0.0055 | 0.0452 | 0.0335 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0312 | 0.0391 |
Leishmania major | fk506-binding protein 1-like protein | 0.0056 | 0.0469 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0055 | 0.0452 | 0.0314 |
Echinococcus granulosus | peptidase s8 s53 subtilisin kexin sedolisin | 0.01 | 0.1365 | 0.1087 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0056 | 0.0469 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.0404 | 0.0505 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0056 | 0.0469 | 0.5 |
Echinococcus multilocularis | fk506 binding protein | 0.0056 | 0.0469 | 0.0352 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0056 | 0.0469 | 0.0352 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.2692 | 0.5349 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0053 | 0.0404 | 0.0205 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0056 | 0.0469 | 0.5 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0056 | 0.0469 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 10 (mg/kg); Activity between positive and negative control groups | ChEMBL. | 2562852 |
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 3.16 (mg/kg); Activity between positive and negative control groups | ChEMBL. | 2562852 |
PFA (functional) | 0 mg kg-1 | Oral antiallergy activity in the passive foot anaphylaxis (PFA) model of rat, at a dose of 1.0 (mg/kg); not significantly different from negative control group | ChEMBL. | 2562852 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.