Detailed information for compound 1983263

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 453.579 | Formula: C28H31N5O
  • H donors: 2 H acceptors: 3 LogP: 4.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc2c(c1)c(n[nH]2)c1ccncc1)NC1CCCCN(C1)CCCc1ccccc1
  • InChi: 1S/C28H31N5O/c34-28(23-11-12-26-25(19-23)27(32-31-26)22-13-15-29-16-14-22)30-24-10-4-5-17-33(20-24)18-6-9-21-7-2-1-3-8-21/h1-3,7-8,11-16,19,24H,4-6,9-10,17-18,20H2,(H,30,34)(H,31,32)
  • InChiKey: JBGVLSLGMIGHKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus mitogen-activated protein kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 358 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.428 0.428
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0008 0.0297 0.0297
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.7687 0.5
Brugia malayi MAP kinase sur-1 0.0062 0.7687 0.7687
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.7687 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.082 0.082
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.7687 1
Schistosoma mansoni coup transcription factor 0.0078 1 1
Schistosoma mansoni thyroid hormone receptor 0.0078 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.082 0.082
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.4861 0.4861
Brugia malayi hypothetical protein 0.0037 0.428 0.428
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.7687 0.7687
Schistosoma mansoni nuclear receptor 0.0037 0.428 0.428
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0008 0.0297 0.0297
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.4892 0.4892
Echinococcus multilocularis thyroid hormone receptor alpha 0.0078 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0297 0.0297
Brugia malayi steroid hormone receptor 0.0078 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.082 0.082
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.082 0.082
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 1 1
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.082 0.082
Brugia malayi Nuclear hormone receptor-like 1 0.0078 1 1
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0008 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Plasmodium falciparum cGMP-dependent protein kinase 0.0006 0 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.0078 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 1 1
Schistosoma mansoni 60S ribosomal protein L21 0.0006 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.428 0.428
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 1 1
Schistosoma mansoni zinc finger protein 0.0037 0.428 0.428
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.4892 0.4892
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 1 1
Brugia malayi conserved hypotetical protein 0.0037 0.428 0.428
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.428 0.428
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.082 0.082
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0297 0.0297
Echinococcus granulosus FTZ F1 alpha 0.0078 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0297 0.0297
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.428 0.428
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.428 0.428
Trypanosoma brucei protein kinase, putative 0.0062 0.7687 0.5
Schistosoma mansoni nuclear hormone receptor 0.0078 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 1 1
Schistosoma mansoni voltage-gated potassium channel 0.0008 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.4892 0.4892
Loa Loa (eye worm) hypothetical protein 0.0036 0.411 0.411
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Loa Loa (eye worm) hypothetical protein 0.0008 0.0297 0.0297
Brugia malayi hypothetical protein 0.0041 0.4892 0.4892
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 1 1
Brugia malayi Nuclear hormone receptor E75 0.0037 0.428 0.428
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.7687 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.4892 0.4892
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.428 0.428
Brugia malayi nuclear hormone receptor 0.0037 0.428 0.428
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0008 0.0297 0.0297
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.7687 0.7687
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0297 0.0297
Schistosoma mansoni voltage-gated potassium channel 0.0006 0.0069 0.0069
Schistosoma mansoni retinoic acid receptor RXR 0.0078 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0078 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.4892 0.4892
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 1 1
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0008 0.0297 0.0297
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.5384 0.5384
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.7687 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0297 0.0297
Echinococcus granulosus hyperpolarization activated cyclic 0.0008 0.0297 0.0297
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.4861 0.4861
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.4861 0.4861
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.7687 0.5
Onchocerca volvulus 0.0078 1 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 1 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.428 0.428
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 1 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.428 0.428
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.4892 0.4892
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.428 0.428
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 1 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.428 0.428
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 1 1
Loa Loa (eye worm) DR-78 0.0037 0.428 0.428
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 1 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0297 0.0297
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0037 0.428 0.428
Brugia malayi Cyclic-nucleotide gated cation channel 0.0008 0.0297 0.0297
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0008 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.428 0.428
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.082 0.082
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.7687 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.428 0.428
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 1 1
Schistosoma mansoni thyroid hormone receptor 0.0078 1 1
Schistosoma mansoni nuclear hormone receptor 0.0037 0.428 0.428
Brugia malayi hypothetical protein 0.0041 0.4892 0.4892
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.428 0.428
Brugia malayi nuclear hormone receptor 0.0078 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.7687 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 1 1
Brugia malayi ecdysone receptor 0.0037 0.428 0.428
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.7687 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.428 0.428
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.7687 0.7687
Brugia malayi nuclear receptor RXR 0.0041 0.4892 0.4892
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.7687 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.428 0.428
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Brugia malayi Steroid receptor seven-up type 2 0.0078 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.4892 0.4892
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.4487 0.5669
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0297 0.0297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 1 1
Brugia malayi nuclear receptor NHR-67 0.0037 0.428 0.428
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.7687 0.7687
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0008 0.0297 0.0297
Brugia malayi nuclear receptor NHR-88 0.0037 0.428 0.428
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.428 0.428
Brugia malayi nuclear receptor NHR-88 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Schistosoma mansoni RAR-like nuclear receptor 0.0078 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 1 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.7687 0.7687
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 1 1
Brugia malayi Nuclear hormone receptor E75 0.0037 0.428 0.428
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.7687 0.5
Schistosoma mansoni nuclear receptor 0.0037 0.428 0.428
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.4892 0.4892
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0008 0.0297 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 1 1
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.428 0.428
Echinococcus granulosus voltage gated potassium channel 0.0012 0.082 0.082
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.428 0.428
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0038 0.4487 0.5669
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0008 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.4861 0.4861
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.7687 0.7687
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 1 1
Brugia malayi nuclear receptor RXR 0.0037 0.428 0.428
Brugia malayi tailless protein 0.0037 0.428 0.428
Echinococcus multilocularis FTZ F1 alpha 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.7687 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.428 0.428
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.4892 0.4892
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.4892 0.4892
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.7687 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.5384 0.5384
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Schistosoma mansoni nuclear hormone receptor 0.0037 0.428 0.428
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.428 0.428
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.428 0.428
Brugia malayi hypothetical protein 0.0037 0.428 0.428
Onchocerca volvulus Bile acid receptor homolog 0.0078 1 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.428 0.428
Echinococcus multilocularis hyperpolarization activated cyclic 0.0008 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0041 0.4892 0.4892
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.4892 0.4892

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 72.48 nM BindingDB_Patents: IMAP Assay. Condition 1: Activated ERK2 activity was also determined in the IMAP assay format using the procedure outlined above. 1 µl of 25× compound was added to 140 of kinase buffer containing 0.25 ng fully phosphorylated, active Mouse ERK2 protein. Following a 30 minute incubation, the reactions were initiated by addition of 10 µl of kinase buffer containing 1 µM ERK2 IMAP substrate peptide (0.9 µM unlabeled IPTTPITTTYFFFK-CONH2 and 100 nM IPTTPITTTYFFFK(5-carboxyfluorescein)-CONH2) and 30 µM ATP. Reactions proceeded for 30 minutes before termination by addition of 60 µl IMAP detection beads in binding buffer. Plates were read as above after 30 minute binding equilibration. Active compounds were reconfirmed in an independent assay. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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