Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ketohexokinase (fructokinase) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Onchocerca volvulus | Get druggable targets OG5_133459 | All targets in OG5_133459 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | ribokinase, putative | ketohexokinase (fructokinase) | 298 aa | 307 aa | 21.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0012 | 0.0029 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Leishmania major | adenosine kinase-like protein | 0.0012 | 0.0029 | 0.0498 |
Giardia lamblia | Beta tubulin | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0029 | 0.0498 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Echinococcus granulosus | beta tubulin | 0.0029 | 0.0579 | 1 |
Trypanosoma brucei | beta tubulin | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0029 | 0.0029 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0029 | 0.0579 | 0.0579 |
Echinococcus granulosus | beta tubulin | 0.0029 | 0.0579 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0029 | 0.0579 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0029 | 0.0579 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0012 | 0.0029 | 0.0498 |
Loa Loa (eye worm) | hypothetical protein | 0.0312 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0029 | 0.0579 | 0.0579 |
Leishmania major | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Brugia malayi | Adenosine kinase-like | 0.0012 | 0.0029 | 0.0029 |
Entamoeba histolytica | tubulin family protein | 0.0029 | 0.0579 | 1 |
Trypanosoma brucei | beta tubulin | 0.0029 | 0.0579 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0029 | 0.0579 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0029 | 0.0579 | 0.0579 |
Schistosoma mansoni | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Entamoeba histolytica | fructokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Loa Loa (eye worm) | tubulin beta chain | 0.0029 | 0.0579 | 0.0579 |
Trichomonas vaginalis | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Trypanosoma brucei | beta tubulin | 0.0029 | 0.0579 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0029 | 0.0579 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0029 | 0.0579 | 0.0579 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0012 | 0.0029 | 0.0498 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Trichomonas vaginalis | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0012 | 0.0029 | 0.0498 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0012 | 0.0029 | 0.5 |
Brugia malayi | Ribokinase | 0.0012 | 0.0029 | 0.0029 |
Giardia lamblia | Beta tubulin | 0.0029 | 0.0579 | 1 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0012 | 0.0029 | 0.0498 |
Entamoeba histolytica | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Leishmania major | putative PfkB family sugar kinase | 0.0012 | 0.0029 | 0.0498 |
Giardia lamblia | Beta tubulin | 0.0029 | 0.0579 | 1 |
Trypanosoma brucei | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Echinococcus granulosus | ribokinase | 0.0012 | 0.0029 | 0.0498 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Entamoeba histolytica | kinase, PfkB family | 0.0012 | 0.0029 | 0.0498 |
Toxoplasma gondii | beta-tubulin, putative | 0.0029 | 0.0579 | 1 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0012 | 0.0029 | 0.0498 |
Toxoplasma gondii | kinase, pfkB family protein | 0.0012 | 0.0029 | 0.0498 |
Schistosoma mansoni | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0029 | 0.0579 | 1 |
Leishmania major | tagatose-6-phosphate kinase-like protein | 0.0012 | 0.0029 | 0.0498 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Brugia malayi | beta-tubulin, identical | 0.0029 | 0.0579 | 0.0579 |
Giardia lamblia | Ribokinase | 0.0012 | 0.0029 | 0.0498 |
Onchocerca volvulus | 0.0312 | 1 | 1 | |
Plasmodium vivax | tubulin beta chain, putative | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2892 | 0.2892 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0012 | 0.0029 | 0.5 |
Echinococcus granulosus | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Brugia malayi | hypothetical protein | 0.0232 | 0.7333 | 0.7333 |
Schistosoma mansoni | ribokinase | 0.0012 | 0.0029 | 0.0498 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0029 | 0.0579 | 1 |
Trypanosoma brucei | beta tubulin | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Toxoplasma gondii | beta tubulin | 0.0029 | 0.0579 | 1 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0012 | 0.0029 | 0.5 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0029 | 0.0579 | 0.0579 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0029 | 0.0579 | 1 |
Leishmania major | adenosine kinase-like protein | 0.0012 | 0.0029 | 0.0498 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0029 | 0.0579 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0029 | 0.0579 | 0.0579 |
Trypanosoma brucei | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Schistosoma mansoni | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Trypanosoma brucei | adenosine kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Echinococcus granulosus | adenosine kinase | 0.0012 | 0.0029 | 0.0498 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0012 | 0.0029 | 0.5 |
Echinococcus multilocularis | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0029 | 0.0579 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0029 | 0.0579 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0029 | 0.0029 |
Schistosoma mansoni | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0029 | 0.0579 | 1 |
Echinococcus multilocularis | ribokinase | 0.0012 | 0.0029 | 0.0498 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0029 | 0.0579 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0012 | 0.0029 | 0.0498 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0029 | 0.0579 | 0.0579 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0029 | 0.0579 | 1 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Leishmania major | adenosine kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0012 | 0.0029 | 0.5 |
Echinococcus multilocularis | beta tubulin | 0.0029 | 0.0579 | 1 |
Schistosoma mansoni | adenosine kinase | 0.0012 | 0.0029 | 0.0498 |
Echinococcus multilocularis | adenosine kinase | 0.0012 | 0.0029 | 0.0498 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Trypanosoma cruzi | ribokinase, putative | 0.0012 | 0.0029 | 0.0498 |
Leishmania major | beta tubulin | 0.0029 | 0.0579 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0029 | 0.0579 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0029 | 0.0579 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0012 | 0.0029 | 0.0498 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 420 nM | BindingDB_Patents: Enzyme Assay. An enzymatic assay was developed to measure KHK-mediated conversion of D-fructose to Fructose-1-P (F-1-P) using High Throughput Mass Spectroscopy (HTMS) as a means of product detection. This assay served as a primary screen to evaluate the ability to inhibit KHK enzyme activity and it has been adapted to high throughput mass spectrometry (HTMS, BioTrove RapidFire) format for higher throughput.The compounds to be tested were dosed in 12-points concentration from 511 uM to 0.5 uM. Inhibition of the fragment, IC50, was determined in a dose-response curve under the established steady-state conditions of 200 uM fructose, 100 uM ATP and 2 nM KHK for 60 min at 25 C. The assay was carried out in 384-well plate format. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.