TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 458.505 | Formula: C15H19N2NaO7S3
H donors: 2 H acceptors: 6 LogP: 0.59 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCCS(=O)c1cc(NCc2ccco2)c(cc1S(=O)(=O)N)S(=O)(=O)[O-].[Na+]
InChi: 1S/C15H20N2O7S3.Na/c1-2-3-7-25(18)13-8-12(17-10-11-5-4-6-24-11)14(27(21,22)23)9-15(13)26(16,19)20;/h4-6,8-9,17H,2-3,7,10H2,1H3,(H2,16,19,20)(H,21,22,23);/q;+1/p-1
InChiKey: YTRBKIHCJLMJFJ-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0028	0.0028
Echinococcus multilocularis	neuropeptides capa receptor	0.014	0.0169	0.0167
Entamoeba histolytica	hypothetical protein	0.0039	0.0003	0.0081
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	neuropeptide receptor	0.014	0.0169	0.0168
Mycobacterium tuberculosis	Hypothetical protein	0.0328	0.0473	0.0311
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Echinococcus multilocularis	neuropeptide receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	alpha-1 adrenergic receptor	0.014	0.0169	0.0168
Echinococcus granulosus	neuropeptide FF receptor 2	0.014	0.0169	0.0167
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.014	0.0169	0.0167
Schistosoma mansoni	amine GPCR	0.014	0.0169	0.0168
Schistosoma mansoni	neuropeptide f receptor 76f	0.014	0.0169	0.0168
Echinococcus granulosus	tachykinin peptides receptor 99D	0.014	0.0169	0.0167
Brugia malayi	protein kinase C II.	0.0038	0.0001	0.0001
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0038	0.0001	0.0001
Brugia malayi	GnHR receptor homolog	0.014	0.0169	0.0168
Echinococcus granulosus	g-protein coupled receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus granulosus	peptide allatostatin:somatostatin	0.014	0.0169	0.0167
Echinococcus multilocularis	somatostatin receptor	0.014	0.0169	0.0167
Entamoeba histolytica	protein kinase, putative	0.0109	0.0118	0.4375
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0202	0.0268	0.5671
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.3232	0.5189	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.014	0.0169	0.0168
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.014	0.0169	0.0167
Brugia malayi	ORL1-like opioid receptor	0.014	0.0169	0.0168
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.014	0.0169	0.0168
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.014	0.0169	0.0167
Echinococcus granulosus	g protein coupled receptor	0.014	0.0169	0.0167
Echinococcus multilocularis	G-protein coupled receptor, putative	0.014	0.0169	0.0167
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.3232	0.5189	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0003	0.0002
Schistosoma mansoni	neuropeptide F-like receptor	0.014	0.0169	0.0168
Echinococcus granulosus	neuropeptides capa receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.014	0.0169	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0328	0.0473	1
Loa Loa (eye worm)	hypothetical protein	0.0415	0.0615	0.0614
Echinococcus granulosus	tm gpcr rhodopsin	0.014	0.0169	0.0167
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.014	0.0169	0.0167
Echinococcus multilocularis	neuropeptide s receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0038	0.0001	0.0001
Echinococcus granulosus	orexin receptor type 2	0.014	0.0169	0.0167
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0028	0.0028
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.013	0.2744
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0202	0.0268	0.0268
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.014	0.0169	0.0168
Schistosoma mansoni	hypothetical protein	0.014	0.0169	0.0168
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.014	0.0169	0.0167
Echinococcus granulosus	sex peptide receptor	0.014	0.0169	0.0167
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0003	0.0003
Chlamydia trachomatis	dihydrofolate reductase	0.6195	1	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.014	0.0169	0.0168
Echinococcus granulosus	biogenic amine 5HT receptor	0.014	0.0169	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.013	0.2744
Brugia malayi	G-protein coupled receptor	0.014	0.0169	0.0168
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0073	0.0059	0.0057
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	growth hormone secretagogue receptor	0.014	0.0169	0.0168
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.6195	1	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0328	0.0473	0.0839
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.015	0.015
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.014	0.0169	0.0168
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0001	0.0001
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.014	0.0169	0.0168
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.014	0.0169	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0038	0.0001	0.0028
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.014	0.0169	0.0168
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0202	0.0268	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.014	0.0169	0.0167
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.069	0.1061	0.1061
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.014	0.0169	0.0168
Echinococcus granulosus	biogenic amine 5HT receptor	0.0415	0.0615	0.0613
Brugia malayi	Hr1 repeat family protein	0.0038	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus granulosus	neuropeptide receptor A26	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0038	0.0001	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0415	0.0615	0.0614
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Echinococcus multilocularis	fmrfamide receptor	0.014	0.0169	0.0167
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Echinococcus multilocularis	dihydrofolate reductase	0.6195	1	1
Schistosoma mansoni	amine GPCR	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.014	0.0169	0.0168
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.3232	0.5189	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Brugia malayi	Protein kinase domain containing protein	0.0038	0.0001	0.0001
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0202	0.0268	1
Brugia malayi	larval opioid receptor	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0028	0.0028
Echinococcus granulosus	dro:myosuppressin receptor	0.014	0.0169	0.0167
Brugia malayi	sulfakinin receptor protein	0.014	0.0169	0.0168
Echinococcus multilocularis	fmrfamide receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Brugia malayi	thymidylate synthase	0.069	0.1061	0.1061
Echinococcus granulosus	dihydrofolate reductase	0.6195	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.014	0.0169	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.013	0.2744
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Echinococcus granulosus	serine/threonine protein kinase	0.008	0.007	0.0069
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0202	0.0268	0.5671
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.6195	1	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	biogenic amine receptor	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.007	0.2581
Echinococcus multilocularis	orexin receptor type 2	0.014	0.0169	0.0167
Schistosoma mansoni	hypothetical protein	0.0039	0.0003	0.0003
Brugia malayi	Serotonin receptor	0.014	0.0169	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus granulosus	g protein coupled receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0073	0.0059	0.0033
Echinococcus multilocularis	neuropeptide receptor A26	0.014	0.0169	0.0167
Brugia malayi	Melatonin receptor type 1A	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	neuropeptide receptor	0.014	0.0169	0.0168
Echinococcus granulosus	neuropeptide s receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.014	0.0169	0.0167
Echinococcus multilocularis	neuropeptide receptor	0.014	0.0169	0.0167
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.014	0.0169	0.0168
Schistosoma mansoni	histamine h1 receptor	0.014	0.0169	0.0168
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0202	0.0268	0.0268
Entamoeba histolytica	hypothetical protein	0.0039	0.0003	0.0081
Schistosoma mansoni	amine GPCR	0.014	0.0169	0.0168
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0072	0.0057	0.0056
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0003	0.0002
Onchocerca volvulus		0.0202	0.0268	0.112
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.014	0.0169	0.0167
Brugia malayi	AKH receptor	0.014	0.0169	0.0168
Echinococcus granulosus	allatostatin A receptor	0.014	0.0169	0.0167
Echinococcus granulosus	fmrfamide receptor	0.014	0.0169	0.0167
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.008	0.007	0.0056
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0202	0.0268	0.5671
Echinococcus multilocularis	allatostatin A receptor	0.014	0.0169	0.0167
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Echinococcus granulosus	nervana 2	0.0072	0.0057	0.0056
Schistosoma mansoni	opsin-like receptor	0.014	0.0169	0.0168
Brugia malayi	RE15519p	0.014	0.0169	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0038	0.0001	0.0028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.014	0.0169	0.0168
Onchocerca volvulus		0.069	0.1061	1
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Brugia malayi	Dopamine receptor	0.014	0.0169	0.0168
Entamoeba histolytica	hypothetical protein	0.0039	0.0003	0.0081
Echinococcus multilocularis	Glutaredoxin protein 5	0.0072	0.0057	0.0056
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.3232	0.5189	1
Brugia malayi	putative neuropeptide receptor	0.014	0.0169	0.0168
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Brugia malayi	hypothetical protein	0.0328	0.0473	0.0473
Schistosoma mansoni	opsin-like receptor	0.014	0.0169	0.0168
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0117	0.013	0.0172
Echinococcus multilocularis	thymidylate synthase	0.069	0.1061	0.106
Schistosoma mansoni	hypothetical protein	0.014	0.0169	0.0168
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0062	0.0042	0.0877
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0038	0.0001	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Schistosoma mansoni	serine/threonine kinase	0.0038	0.0001	0.0001
Echinococcus granulosus	neuropeptide receptor	0.014	0.0169	0.0167
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus granulosus	neuropeptide Y receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0109	0.0118	0.0118
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Entamoeba histolytica	hypothetical protein	0.0039	0.0003	0.0081
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.014	0.0169	0.0168
Echinococcus multilocularis	g protein coupled receptor	0.014	0.0169	0.0167
Echinococcus granulosus	7TM GPCR rhodopsin	0.014	0.0169	0.0167
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.014	0.0169	0.0167
Echinococcus granulosus	tm gpcr rhodopsin	0.014	0.0169	0.0167
Brugia malayi	p70 ribosomal S6 kinase beta	0.0109	0.0118	0.0118
Entamoeba histolytica	protein kinase, putative	0.0117	0.013	0.4812
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0038	0.0001	0.0001
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.014	0.0169	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.013	0.2744
Echinococcus granulosus	alpha 1A adrenergic receptor	0.014	0.0169	0.0167
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.014	0.0169	0.0168
Schistosoma mansoni	dihydrofolate reductase	0.6195	1	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.0073	0.0059	0.0057
Echinococcus granulosus	thymidylate synthase	0.069	0.1061	0.106
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.013	0.2744
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0415	0.0615	0.0614
Brugia malayi	G protein-coupled receptor	0.014	0.0169	0.0168
Echinococcus granulosus	hypothetical protein	0.014	0.0169	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.013	0.2744
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0001	0.0001
Brugia malayi	G protein-coupled receptor F59B2.13	0.014	0.0169	0.0168
Schistosoma mansoni	serine/threonine-protein kinase	0.008	0.007	0.007
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0001	0.0001
Schistosoma mansoni	neuropeptide receptor	0.014	0.0169	0.0168
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.015	0.015
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0072	0.0057	0.0056
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.014	0.0169	0.0168
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0202	0.0268	1
Echinococcus granulosus	somatostatin receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.014	0.0169	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Echinococcus multilocularis	g protein coupled receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	melatonin receptor type 1A	0.014	0.0169	0.0168
Schistosoma mansoni	atypical protein kinase C	0.0038	0.0001	0.0001
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.3232	0.5189	1
Echinococcus multilocularis	nervana 2	0.0072	0.0057	0.0056
Echinococcus multilocularis	nervana 2	0.0072	0.0057	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0001	0.0001
Echinococcus granulosus	Glutaredoxin protein 5	0.0072	0.0057	0.0056
Schistosoma mansoni	amine GPCR	0.014	0.0169	0.0168
Echinococcus multilocularis	sex peptide receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0001	0.0001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.014	0.0169	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0001	0.0001
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Trichomonas vaginalis	AGC family protein kinase	0.0045	0.0013	0.0275
Brugia malayi	neuropeptide F receptor	0.014	0.0169	0.0168
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.014	0.0169	0.0168
Echinococcus multilocularis	serotonin receptor	0.0415	0.0615	0.0613
Echinococcus multilocularis	serotonin receptor	0.0415	0.0615	0.0613
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0038	0.0001	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Schistosoma mansoni	serine/threonine-protein kinase	0.008	0.007	0.007
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus granulosus	serotonin receptor	0.014	0.0169	0.0167
Brugia malayi	follicle stimulating hormone receptor	0.014	0.0169	0.0168
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.014	0.0169	0.0167
Loa Loa (eye worm)	TYRA-2 protein	0.014	0.0169	0.0168
Schistosoma mansoni	biogenic amine receptor	0.014	0.0169	0.0168
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Trypanosoma cruzi	Protein kinase B	0.008	0.007	0.0056
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.014	0.0169	0.0167
Brugia malayi	MH2 domain containing protein	0.0129	0.015	0.015
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Entamoeba histolytica	PH domain containing protein kinase, putative	0.008	0.007	0.2581
Schistosoma mansoni	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0038	0.0001	0.0001
Mycobacterium ulcerans	thymidylate synthase	0.069	0.1061	0.0814
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.014	0.0169	0.0168
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.014	0.0169	0.0168
Loa Loa (eye worm)	G-protein coupled receptor	0.014	0.0169	0.0168
Echinococcus multilocularis	neuropeptide Y receptor	0.014	0.0169	0.0167
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0202	0.0268	0.5671
Schistosoma mansoni	opsin-like receptor	0.014	0.0169	0.0168
Schistosoma mansoni	myosin xvIII	0.014	0.0169	0.0168
Echinococcus granulosus	tm gpcr rhodopsin	0.014	0.0169	0.0167
Echinococcus granulosus	g protein coupled receptor	0.014	0.0169	0.0167
Schistosoma mansoni	neuropeptide receptor	0.014	0.0169	0.0168
Entamoeba histolytica	protein kinase, putative	0.0117	0.013	0.4812
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.014	0.0169	0.0168
Echinococcus multilocularis	G protein coupled receptor 139	0.014	0.0169	0.0167
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.014	0.0169	0.0167
Loa Loa (eye worm)	dihydrofolate reductase	0.6195	1	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.014	0.0169	0.0167
Brugia malayi	Dopamine receptor protein 2	0.014	0.0169	0.0168
Echinococcus multilocularis	dro:myosuppressin receptor	0.014	0.0169	0.0167
Brugia malayi	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0062	0.0042	0.0877
Brugia malayi	G-protein coupled receptor	0.014	0.0169	0.0168
Echinococcus multilocularis	neuropeptide Y receptor	0.014	0.0169	0.0167
Entamoeba histolytica	protein kinase 2, putative	0.0073	0.0059	0.2143
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0073	0.0059	0.0057
Brugia malayi	neuropeptide F receptor	0.014	0.0169	0.0168
Schistosoma mansoni	biogenic amine receptor	0.014	0.0169	0.0168
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.069	0.1061	0.0909
Echinococcus granulosus	neuropeptide Y receptor	0.014	0.0169	0.0167
Echinococcus granulosus	neuropeptides capa receptor	0.014	0.0169	0.0167
Echinococcus granulosus	G protein coupled receptor 139	0.014	0.0169	0.0167
Brugia malayi	Protein kinase domain containing protein	0.0117	0.013	0.013
Brugia malayi	hypothetical protein	0.0039	0.0003	0.0003
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.014	0.0169	0.0167
Brugia malayi	Dopamine receptor protein 1	0.0546	0.0827	0.0827
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0117	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.0546	0.0827	0.0827
Loa Loa (eye worm)	thymidylate synthase	0.069	0.1061	0.1061
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.014	0.0169	0.0168
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0202	0.0268	0.5671
Echinococcus granulosus	neuropeptide receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.3232	0.5189	1
Echinococcus multilocularis	g protein coupled receptor	0.014	0.0169	0.0167
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.014	0.0169	0.0168
Schistosoma mansoni	amine GPCR	0.014	0.0169	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Loa Loa (eye worm)	neuropeptide F receptor	0.014	0.0169	0.0168
Schistosoma mansoni	serine/threonine protein kinase	0.0038	0.0001	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Brugia malayi	Dihydrofolate reductase	0.6195	1	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.014	0.0169	0.0167
Brugia malayi	Serotonin receptor	0.0657	0.1008	0.1008
Echinococcus granulosus	nervana 2	0.0072	0.0057	0.0056
Brugia malayi	putative neuropeptide receptor NPR1	0.014	0.0169	0.0168
Echinococcus multilocularis	rac serine:threonine kinase	0.008	0.007	0.0069
Echinococcus multilocularis	g-protein coupled receptor	0.014	0.0169	0.0167
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.014	0.0169	0.0167
Trichomonas vaginalis	AGC family protein kinase	0.0117	0.013	0.2744
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0202	0.0268	0.5671
Schistosoma mansoni	adenoreceptor	0.014	0.0169	0.0168
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.014	0.0169	0.0168
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.014	0.0169	0.0167
Loa Loa (eye worm)	hypothetical protein	0.014	0.0169	0.0168
Echinococcus granulosus	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.6195	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0028	0.0028
Echinococcus multilocularis	neuropeptides capa receptor	0.014	0.0169	0.0167
Schistosoma mansoni	neuropeptide F-like receptor	0.014	0.0169	0.0168
Echinococcus granulosus	7tm_1 domain containing protein	0.014	0.0169	0.0167
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167
Echinococcus multilocularis	rhodopsin orphan GPCR	0.014	0.0169	0.0167

Activities

Activity type	Activity value	Assay description	Source	Reference
Diuretic activity (functional)	= 1 ml kg-1	Diuretic activity in the rats, determined by a modified Lipschitz test	ChEMBL.	6876086
Diuretic activity (functional)	= 34.9 ml kg-1 6hr-1	Diuretic activity in the dog (2 animals/dose) at (dose 1.56 mg/Kg), when administered perorally	ChEMBL.	6876086
Ratio (functional)	= 1	It is the ratio, measured as saluretic activity in the dog as concentration of Cl- in urinary excretion (dose 1.56 mg/Kg, po) to that of (Na+)+(K+)	ChEMBL.	6876086
Ratio (functional)	= 3	It is the ratio, measured as saluretic activity in the dog as concentration of Na+ in urinary excretion (dose 1.56 mg/Kg, po) to that of K	ChEMBL.	6876086
Saldiuretic activity (functional)	= 0.35 (m equiv) 6hr-1 kg-1	Saluretic activity in the dog measured as concentration of K+ in urinary excretion (2 animals/dose) (dose 1.56 mg/Kg,po)	ChEMBL.	6876086
Saldiuretic activity (functional)	= 1.43 m equiv 6hr-1 kg-1	Saluretic activity in the dog measured as concentration of Cl - in urinary excretion (2 animals/dose) at (dose 1.56 mg/Kg, po)	ChEMBL.	6876086
Saluretic activity (functional)	= 0.9 m equiv 5hr-1 kg-1	Saluretic activity in the rat measured as concentration of Na+ in urine	ChEMBL.	6876086
Saluretic activity (functional)	= 1 m equiv 5hr-1 kg-1	Saluretic activity in the rat measured as concentration of K+ in urine	ChEMBL.	6876086
Saluretic activity (functional)	= 1.4 m equiv 5hr-1 kg-1	Saluretic activity in the rat measured as concentration of chloride in urine	ChEMBL.	6876086
Saluretic activity (functional)	= 0.89 m equiv 6hr-1 kg-1	Saluretic activity in the dog measured as concentration of Na+ in urinary excretion (2 animals/dose) at (dose 1.56 mg/Kg, po)	ChEMBL.	6876086

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL17999

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 19915