Detailed information for compound 1996770

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 391.304 | Formula: C17H12F3N5O3
  • H donors: 2 H acceptors: 5 LogP: 2.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(C(=O)N)c2c(c1)c(ncn2)NCc1cccc(c1)C(F)(F)F
  • InChi: 1S/C17H12F3N5O3/c18-17(19,20)10-3-1-2-9(4-10)7-22-16-13-6-11(25(27)28)5-12(15(21)26)14(13)23-8-24-16/h1-6,8H,7H2,(H2,21,26)(H,22,23,24)
  • InChiKey: SXLJOZVUCVEXKL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ribosomal protein S6 kinase, 70kDa, polypeptide 1 Starlite/ChEMBL No references
Homo sapiens aurora kinase A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K04456 RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae YPK2 (YMR104C) Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/RSK/P70 protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine-protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum RAC serine/threonine-protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis rac serine:threonine kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus calcium:calmodulin dependent protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi Protein kinase B Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum Ribosomal protein S6 kinase alpha-6 (EC 2.7.11.1), related Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus multilocularis nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi p70 ribosomal S6 kinase beta Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis Glutaredoxin protein 5 Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium vivax rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii kinase Akt/PKB-related Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium knowlesi RAC-beta serine/threonine protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08792 serum/glucocorticoid regulated kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum ko:K07390 monothiol glutaredoxin, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei rac-beta serine/threonine protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii AGC kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine threonine protein kinase nrc Get druggable targets OG5_126635 All targets in OG5_126635
Loa Loa (eye worm) AGC/AKT protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma brucei gambiense rac serine-threonine kinase, putative,protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase 2, putative Get druggable targets OG5_126635 All targets in OG5_126635
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126635 All targets in OG5_126635
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Echinococcus granulosus nervana 2 Get druggable targets OG5_126635 All targets in OG5_126635
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi rac serine-threonine kinase, putative Get druggable targets OG5_126635 All targets in OG5_126635
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ethanolamine kinase 2 0.0038 0.031 0.031
Echinococcus multilocularis Glutaredoxin protein 5 0.0033 0.018 0.018
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.1157 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.3587 0.3587
Echinococcus granulosus choline:ethanolamine kinase 0.039 1 1
Trypanosoma cruzi choline kinase 0.0038 0.031 0.1102
Echinococcus granulosus serine threonine protein kinase nrc 0.0034 0.0205 0.0205
Giardia lamblia Aurora kinase 0.0068 0.1157 1
Loa Loa (eye worm) AUR protein kinase 0.0068 0.1157 0.1157
Trichomonas vaginalis choline/ethanolamine kinase, putative 0.0038 0.031 0.268
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.1157 0.3226
Echinococcus multilocularis ethanolamine kinase 2 0.0038 0.031 0.031
Brugia malayi serine/threonine kinase 12 0.0068 0.1157 0.1157
Entamoeba histolytica protein kinase, putative 0.0068 0.1157 1
Onchocerca volvulus Putative choline\/ethanolamine kinase 0.0038 0.031 1
Trichomonas vaginalis AGC family protein kinase 0.0068 0.1157 1
Brugia malayi p70 ribosomal S6 kinase beta 0.0051 0.0669 0.0669
Loa Loa (eye worm) choline/ethanolamine kinase 0.039 1 1
Schistosoma mansoni protein kinase 0.0068 0.1157 0.3226
Loa Loa (eye worm) choline/ethanolamine kinase 0.0038 0.031 0.031
Entamoeba histolytica protein kinase, putative 0.0051 0.0669 0.4871
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0157 0.3587 1
Echinococcus multilocularis nervana 2 0.0033 0.018 0.018
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0034 0.0205 0.0205
Trypanosoma brucei rac serine-threonine kinase, putative 0.0051 0.0669 0.4235
Echinococcus multilocularis nervana 2 0.0033 0.018 0.018
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0669 0.578
Schistosoma mansoni serine/threonine-protein kinase 0.0034 0.0205 0.0572
Echinococcus granulosus carboxylesterase 5A 0.0157 0.3587 0.3587
Echinococcus granulosus serine/threonine protein kinase 0.0034 0.0205 0.0205
Echinococcus granulosus acetylcholinesterase 0.0157 0.3587 0.3587
Echinococcus granulosus nervana 2 0.0033 0.018 0.018
Toxoplasma gondii aurora kinase 0.0068 0.1157 0.0874
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.1157 1
Toxoplasma gondii AGC kinase 0.0051 0.0669 0.037
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0033 0.018 0.018
Brugia malayi Protein kinase domain containing protein 0.0051 0.0669 0.0669
Brugia malayi Carboxylesterase family protein 0.0157 0.3587 0.3587
Brugia malayi Choline/ethanolamine kinase family protein 0.0038 0.031 0.031
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.1157 1
Entamoeba histolytica protein kinase, putative 0.0068 0.1157 1
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0669 0.578
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.1157 0.1157
Loa Loa (eye worm) hypothetical protein 0.0038 0.031 0.031
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0033 0.018 0.018
Echinococcus granulosus Glutaredoxin protein 5 0.0033 0.018 0.018
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.1157 1
Trypanosoma brucei aurora B kinase 0.0068 0.1157 1
Echinococcus granulosus aurora kinase A 0.0068 0.1157 0.1157
Entamoeba histolytica protein kinase, putative 0.0051 0.0669 0.4871
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0034 0.0205 0.0205
Brugia malayi Choline/ethanolamine kinase family protein 0.0038 0.031 0.031
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.1157 0.1157
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0669 0.578
Echinococcus granulosus acetylcholinesterase 0.0157 0.3587 0.3587
Echinococcus multilocularis acetylcholinesterase 0.0157 0.3587 0.3587
Schistosoma mansoni choline kinase 0.0038 0.031 0.0865
Loa Loa (eye worm) AUR protein kinase 0.0068 0.1157 0.1157
Loa Loa (eye worm) choline Kinase A 0.0038 0.031 0.031
Echinococcus multilocularis choline:ethanolamine kinase 0.039 1 1
Schistosoma mansoni choline/ethanolamine kinase 0.0038 0.031 0.0865
Schistosoma mansoni choline/ethanolamine kinase 0.0038 0.031 0.0865
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0 0.5
Toxoplasma gondii phosphotransferase enzyme family protein 0.039 1 1
Echinococcus multilocularis aurora kinase A 0.0068 0.1157 0.1157
Plasmodium vivax ethanolamine kinase, putative 0.0038 0.031 0.0107
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0051 0.0669 0.0669
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.1157 0.1157
Trichomonas vaginalis AGC family protein kinase 0.0068 0.1157 1
Plasmodium falciparum choline kinase 0.039 1 1
Plasmodium vivax choline kinase, putative 0.039 1 1
Giardia lamblia Ethanolamine kinase, putative 0.0038 0.031 0.1102
Brugia malayi serine/threonine protein kinase 6 0.0068 0.1157 0.1157
Mycobacterium ulcerans carboxylesterase, LipT 0.0026 0 0.5
Entamoeba histolytica choline/ethanolamine kinase, putative 0.0038 0.031 0.1102
Loa Loa (eye worm) carboxylesterase 0.0157 0.3587 0.3587
Plasmodium falciparum ethanolamine kinase 0.0038 0.031 0.0107
Loa Loa (eye worm) AUR protein kinase 0.0068 0.1157 0.1157
Entamoeba histolytica protein kinase , putative 0.0068 0.1157 1
Echinococcus multilocularis rac serine:threonine kinase 0.0034 0.0205 0.0205
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0669 0.578
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0669 0.578
Entamoeba histolytica choline/ethanolamine kinase, putative 0.0038 0.031 0.1102
Loa Loa (eye worm) hypothetical protein 0.0157 0.3587 0.3587
Echinococcus multilocularis carboxylesterase 5A 0.0157 0.3587 0.3587
Echinococcus granulosus nervana 2 0.0033 0.018 0.018
Echinococcus multilocularis acetylcholinesterase 0.0157 0.3587 0.3587
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0669 0.578
Trichomonas vaginalis AGC family protein kinase 0.0051 0.0669 0.578
Entamoeba histolytica protein kinase, putative 0.0051 0.0669 0.4871
Brugia malayi Carboxylesterase family protein 0.0157 0.3587 0.3587
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.1157 0.0972
Onchocerca volvulus 0.0038 0.031 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.1157 0.0972
Trichomonas vaginalis AGC family protein kinase 0.0068 0.1157 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0026 0 0.5
Loa Loa (eye worm) acetylcholinesterase 1 0.0157 0.3587 0.3587
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.1157 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0026 0 0.5
Schistosoma mansoni serine/threonine-protein kinase 0.0034 0.0205 0.0572
Trypanosoma cruzi choline ethanolamine kinase, putative 0.0038 0.031 0.1102
Loa Loa (eye worm) AGC/AKT protein kinase 0.0051 0.0669 0.0669
Trichomonas vaginalis AGC family protein kinase 0.0068 0.1157 1
Leishmania major protein kinase, putative 0.0068 0.1157 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5900 nM Enzyme Assay BINDINGDB. No reference
IC50 (binding) = 16800 nM BindingDB_Patents: Enzyme Assay. P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compound plate to initiate the enzyme reaction; P70S6K (3 nM, T412E mutant, Millipore) is mixed with 24 µM ATP in an assay buffer containing 100 mM Hepes (pH 7.5), 5 mM MgCl2, 1 mM DTT, 0.015% Brij and 1 µM of the substrate peptide FITC-AHA-AKRRRLSSLRA-OH (derived from the S6 ribosomal protein sequence, FITC=fluorescein isothiocyanate, AHA=6-aminohexanoic acid). The reaction is incubated for 90 min at 25° C., before the addition of 10 mM EDTA to stop the reaction. The proportion of substrate and product (phosphorylated) peptide is analysed on a Caliper Life Sciences Lab Chip 3000, using a pressure of -1.4 psi, and upstream and downstream voltages of -3000 and -700 respectively. ChEMBL. No reference
IC50 (binding) = 16800 nM BindingDB_Patents: Enzyme Assay. P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compound plate to initiate the enzyme reaction; P70S6K (3 nM, T412E mutant, Millipore) is mixed with 24 µM ATP in an assay buffer containing 100 mM Hepes (pH 7.5), 5 mM MgCl2, 1 mM DTT, 0.015% Brij and 1 µM of the substrate peptide FITC-AHA-AKRRRLSSLRA-OH (derived from the S6 ribosomal protein sequence, FITC=fluorescein isothiocyanate, AHA=6-aminohexanoic acid). The reaction is incubated for 90 min at 25° C., before the addition of 10 mM EDTA to stop the reaction. The proportion of substrate and product (phosphorylated) peptide is analysed on a Caliper Life Sciences Lab Chip 3000, using a pressure of -1.4 psi, and upstream and downstream voltages of -3000 and -700 respectively. ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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