TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 393.403 | Formula: C20H22F3N3O2
H donors: 1 H acceptors: 2 LogP: 3.61 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)N[C@H](c1ccc(cc1)O[C@@H]1CCN(C1)c1cccc(n1)C(F)(F)F)C
InChi: 1S/C20H22F3N3O2/c1-13(24-14(2)27)15-6-8-16(9-7-15)28-17-10-11-26(12-17)19-5-3-4-18(25-19)20(21,22)23/h3-9,13,17H,10-12H2,1-2H3,(H,24,27)/t13-,17+/m0/s1
InChiKey: FGRSBSGLTPFGBD-SUMWQHHRSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	acetyl-CoA carboxylase beta	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01961 acetyl-CoA carboxylase [EC6.4.1.2], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania donovani	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma mansoni	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium yoelii	acetyl-CoA carboxylase 1 precursor-related	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium hominis	acetyl-CoA carboxylase 2	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania mexicana	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium knowlesi	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium berghei	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma brucei gambiense	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania braziliensis	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania major	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Leishmania infantum	acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma congolense	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Brugia malayi	Carboxyl transferase domain containing protein	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	ko:K01946 biotin carboxylase [EC6.3.4.14], putative	Get druggable targets OG5_127493	All targets in OG5_127493
Schistosoma japonicum	Acetyl-CoA carboxylase, putative	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-coA carboxylase ACC2	Get druggable targets OG5_127493	All targets in OG5_127493
Candida albicans	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Trypanosoma cruzi	acetyl-CoA carboxylase	Get druggable targets OG5_127493	All targets in OG5_127493
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	Get druggable targets OG5_127493	All targets in OG5_127493
Neospora caninum	hypothetical protein	Get druggable targets OG5_127493	All targets in OG5_127493
Cryptosporidium parvum	acetyl-CoA carboxylase like biotin dependent carboxylase involved in fatty acid biosynthesis	Get druggable targets OG5_127493	All targets in OG5_127493

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	GTPase activating protein	0.0076	0.4576	0.4354
Brugia malayi	Protein kinase domain containing protein	0.0125	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0125	1	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0049	0.1547	0.1201
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	vav2	0.0076	0.4576	0.4354
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0076	0.4576	0.3583
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Chlamydia trachomatis	biotin carboxylase	0.0035	0	0.5
Brugia malayi	Carboxyl transferase domain containing protein	0.0098	0.694	0.638
Echinococcus granulosus	tensin	0.0076	0.4576	0.4354
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0125	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	protein tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	tensin-related	0.0076	0.4576	0.4354
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0049	0.1547	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Onchocerca volvulus		0.0076	0.4576	0.3583
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0125	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1547	0.5
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0076	0.4576	0.3583
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.4576	0.3583
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	tyrosine kinase	0.0125	1	1
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.0039	0.0393	0.5
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0049	0.1547	0.1201
Echinococcus multilocularis	SH2 motif	0.0076	0.4576	0.4354
Echinococcus granulosus	signal transduction protein lnk realted	0.0076	0.4576	0.4354
Brugia malayi	SH2 domain containing protein	0.0076	0.4576	0.3583
Giardia lamblia	Kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine kinase	0.0125	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	tensin	0.0076	0.4576	0.4354
Brugia malayi	hypothetical protein	0.0076	0.4576	0.3583
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0125	1	1
Echinococcus multilocularis	FL cytokine receptor	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.4576	0.3583
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1547	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	signal transduction protein lnk-related	0.0076	0.4576	0.4354
Brugia malayi	SH2 domain containing protein	0.0125	1	1
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	activated cdc42 kinase 1	0.0049	0.1547	0.1201
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Schistosoma mansoni	tensin	0.0076	0.4576	0.4354
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0076	0.4576	0.4354
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0076	0.4576	0.4354
Echinococcus multilocularis		0.0076	0.4576	0.4354
Brugia malayi	SH2 domain containing protein	0.0076	0.4576	0.3583
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	protein tyrosine kinase	0.0049	0.1547	0.1201
Giardia lamblia	Protein 21.1	0.0049	0.1547	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0049	0.1547	0.1201
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.4576	0.3583
Schistosoma mansoni	acetyl-CoA carboxylase	0.0101	0.7333	0.7224
Schistosoma mansoni	tensin-related	0.0076	0.4576	0.4354
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0125	1	1
Trypanosoma brucei	acetyl-CoA carboxylase	0.0101	0.7333	1
Brugia malayi	SH2 domain containing protein	0.0076	0.4576	0.3583
Echinococcus multilocularis	NCK adaptor protein	0.0076	0.4576	0.4354
Schistosoma mansoni	tyrosine kinase	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Onchocerca volvulus		0.0076	0.4576	0.3583
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0125	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0049	0.1547	0.4323
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0049	0.1547	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0125	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0049	0.1547	0.5
Onchocerca volvulus		0.0125	1	1
Leishmania major	protein kinase, putative	0.0049	0.1547	0.1663
Onchocerca volvulus		0.0076	0.4576	0.3583
Echinococcus granulosus	hypothetical protein	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.1547	0.1201
Echinococcus granulosus	raf serine:threonine protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	natriuretic peptide receptor 1	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0076	0.4576	0.4354
Echinococcus granulosus	expressed conserved protein	0.0076	0.4576	0.4354
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Brugia malayi	Protein kinase domain containing protein	0.0125	1	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0049	0.1547	0.1663
Trypanosoma cruzi	protein kinase, putative	0.0049	0.1547	0.4323
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	nck2/grb4	0.0076	0.4576	0.4354
Echinococcus granulosus	SH2 motif	0.0076	0.4576	0.4354
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0049	0.1547	0.1663
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0049	0.1547	0.4323
Echinococcus multilocularis	protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0049	0.1547	0.1201
Onchocerca volvulus		0.0125	1	1
Brugia malayi	Protein kinase domain containing protein	0.0125	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0076	0.4576	0.3583
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0049	0.1547	0.1201
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.4576	0.3583
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0076	0.4576	0.4354
Echinococcus multilocularis	tensin	0.0076	0.4576	0.4354
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.1547	0.1201
Onchocerca volvulus		0.0076	0.4576	0.3583
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Brugia malayi	Tyrosine-protein kinase abl-1	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0125	1	1
Echinococcus granulosus	NCK adaptor protein	0.0076	0.4576	0.4354
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0049	0.1547	0.1201
Echinococcus granulosus	growth factor receptor bound protein 2	0.0076	0.4576	0.4354
Brugia malayi	SH2 domain containing protein	0.0076	0.4576	0.3583
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0076	0.4576	0.3583
Echinococcus granulosus	c src tyrosine kinase	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	SH2 motif	0.0076	0.4576	0.4354
Onchocerca volvulus		0.0125	1	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0049	0.1547	0.1201
Echinococcus multilocularis	SH2 domain containing protein 7	0.0076	0.4576	0.4354
Echinococcus granulosus	acetyl coenzyme A carboxylase 1	0.0101	0.7333	0.7224
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0049	0.1547	0.1201
Echinococcus granulosus	tyrosine protein kinase Srms	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Giardia lamblia	Kinase, NEK	0.0049	0.1547	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0049	0.1547	0.1201
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0076	0.4576	0.4354
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0076	0.4576	0.4354
Loa Loa (eye worm)	hypothetical protein	0.0125	1	1
Echinococcus multilocularis	tyrosine protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine kinase	0.0125	1	1
Echinococcus multilocularis	integrin linked protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.0039	0.0393	0.5
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.0039	0.0393	0.5
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Onchocerca volvulus		0.0076	0.4576	0.3583
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0049	0.1547	0.1201
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Toxoplasma gondii	acetyl-CoA carboxylase ACC1	0.0101	0.7333	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.4576	0.4354
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0049	0.1547	0.1201
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0049	0.1547	0.1663
Echinococcus granulosus	tyrosine protein kinase csk	0.0049	0.1547	0.1201
Onchocerca volvulus		0.0125	1	1
Loa Loa (eye worm)	TK protein kinase	0.0125	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0076	0.4576	0.4354
Echinococcus multilocularis	heat shock protein 70	0.0049	0.1547	0.1201
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Loa Loa (eye worm)	STAT protein	0.0076	0.4576	0.3583
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0076	0.4576	0.3583
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0049	0.1547	0.1201
Echinococcus granulosus	epidermal growth factor receptor	0.0049	0.1547	0.1201
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0125	1	1
Entamoeba histolytica	protein kinase, putative	0.0051	0.1816	0.0319
Schistosoma mansoni	ephrin receptor	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Schistosoma mansoni	serine/threonine RGC	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase shark	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0125	1	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0049	0.1547	0.1201
Schistosoma mansoni	suppressor of cytokine signaling	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0076	0.4576	0.4354
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0049	0.1547	0.1663
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0049	0.1547	0.1201
Trichomonas vaginalis	AGC family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0076	0.4576	0.4354
Onchocerca volvulus		0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	protein kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	kinase suppressor of Ras 1	0.0049	0.1547	0.1201
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0049	0.1547	0.1201
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.0039	0.0393	0.5
Echinococcus granulosus	N chimaerin	0.0076	0.4576	0.4354
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.1547	0.1201
Toxoplasma gondii	protein kinase	0.0049	0.1547	0.1663
Schistosoma mansoni	tensin	0.0076	0.4576	0.4354
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0125	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0076	0.4576	0.3583
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0049	0.1547	0.1201
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0049	0.1547	0.1201
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.0039	0.0393	0.5
Schistosoma mansoni	shc transforming protein	0.0076	0.4576	0.4354
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.4576	0.4354
Echinococcus granulosus	activin receptor type	0.0049	0.1547	0.1201
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Entamoeba histolytica	hypothetical protein	0.0051	0.1816	0.0319
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0076	0.4576	0.3583
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	tyrosine kinase	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0049	0.1547	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Schistosoma mansoni	tensin	0.0076	0.4576	0.4354
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0076	0.4576	0.4354
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0073	0.4235	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.4576	0.3583
Trypanosoma brucei	protein kinase, putative	0.0049	0.1547	0.1663
Schistosoma mansoni	tyrosine protein kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	insulin receptor	0.0049	0.1547	0.1201
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	hypothetical protein	0.0076	0.4576	0.4354
Entamoeba histolytica	protein kinase, putative	0.0076	0.4576	0.3583
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	hypothetical protein	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0125	1	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0051	0.1816	0.0319
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0076	0.4576	0.4354
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0049	0.1547	0.1201
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0076	0.4576	0.4354
Echinococcus granulosus	tyrosine protein kinase csk	0.0049	0.1547	0.1201
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	0.0098	0.694	0.638
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0049	0.1547	0.1201
Loa Loa (eye worm)	SRC-1	0.0125	1	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0049	0.1547	0.1201
Brugia malayi	SH2 domain containing protein	0.0076	0.4576	0.3583
Entamoeba histolytica	hypothetical protein	0.0051	0.1816	0.0319
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	epidermal growth factor receptor	0.0049	0.1547	0.1201
Toxoplasma gondii	protein kinase domain-containing protein	0.0049	0.1547	0.1663
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0076	0.4576	0.3583
Trichomonas vaginalis	CAMK family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0125	1	1
Leishmania major	protein kinase, putative	0.0049	0.1547	0.1663
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.0039	0.0393	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0049	0.1547	0.1201
Brugia malayi	Sex muscle abnormal protein 5	0.0076	0.4576	0.3583
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0125	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0049	0.1547	0.1201
Entamoeba histolytica	SH2 domain containing protein	0.0076	0.4576	0.3583
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0049	0.1547	0.1201
Echinococcus multilocularis	protein kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0049	0.1547	0.1201
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0049	0.1547	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0125	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0049	0.1547	0.1201
Echinococcus multilocularis	epidermal growth factor receptor	0.0049	0.1547	0.1201
Echinococcus granulosus	tyrosine protein kinase shark	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Brugia malayi	SH2 domain containing protein	0.0076	0.4576	0.3583
Echinococcus granulosus	activated cdc42 kinase 1	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Entamoeba histolytica	hypothetical protein	0.0051	0.1816	0.0319
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Brugia malayi	Tensin	0.0076	0.4576	0.3583
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0049	0.1547	0.1201
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0076	0.4576	0.4354
Schistosoma mansoni	serine/threonine protein kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1547	0.5
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	c src tyrosine kinase	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	tyrosine kinase	0.0125	1	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0049	0.1547	0.1201
Toxoplasma gondii	acetyl-coA carboxylase ACC2	0.0101	0.7333	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0125	1	1
Echinococcus granulosus	tyrosine kinase	0.0125	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.4576	0.3583
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.4576	0.4354
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1547	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1547	0.5
Echinococcus multilocularis	N chimaerin	0.0076	0.4576	0.4354
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0049	0.1547	0.1201
Echinococcus multilocularis	SH2 motif	0.0076	0.4576	0.4354
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1547	0.5
Brugia malayi	SH2 domain containing protein	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0076	0.4576	0.3583
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0049	0.1547	0.1201
Brugia malayi	hypothetical protein	0.0125	1	1
Leishmania major	hypothetical protein, conserved	0.0049	0.1547	0.1663
Schistosoma mansoni	suppressor of cytokine signaling	0.0076	0.4576	0.4354
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0049	0.1547	0.1201
Giardia lamblia	Kinase, NEK	0.0049	0.1547	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0049	0.1547	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	SH2 motif	0.0076	0.4576	0.4354
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0125	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Brugia malayi	SH2 domain containing protein	0.0076	0.4576	0.3583
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0125	1	1
Brugia malayi	RhoGAP domain containing protein	0.0076	0.4576	0.3583
Schistosoma mansoni	growth factor receptor-bound protein	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0049	0.1547	0.1201
Schistosoma mansoni	SH2A	0.0076	0.4576	0.4354
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	receptor type guanylyl cyclase	0.0049	0.1547	0.1201
Leishmania major	acetyl-CoA carboxylase, putative	0.0101	0.7333	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0125	1	1
Schistosoma mansoni	hypothetical protein	0.0076	0.4576	0.4354
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	SHC transforming protein 3	0.0076	0.4576	0.4354
Brugia malayi	Protein kinase domain containing protein	0.0125	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0049	0.1547	0.1663
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0125	1	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0125	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0076	0.4576	0.4354
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.4576	0.3583
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0049	0.1547	0.1201
Trypanosoma cruzi	acetyl-CoA carboxylase	0.0063	0.3063	1
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Onchocerca volvulus		0.0125	1	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0076	0.4576	0.4354
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0125	1	1
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.0073	0.4235	1
Echinococcus multilocularis	activin receptor type	0.0049	0.1547	0.1201
Trichomonas vaginalis	TK family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0125	1	1
Onchocerca volvulus		0.0076	0.4576	0.3583
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Schistosoma mansoni	adapter molecule crk	0.0076	0.4576	0.4354
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0076	0.4576	0.3583
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0049	0.1547	0.1663
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0049	0.1547	0.1201
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Toxoplasma gondii	STE kinase	0.0049	0.1547	0.1663
Echinococcus granulosus	insulin receptor	0.0049	0.1547	0.1201
Echinococcus multilocularis	SHC transforming protein 3	0.0076	0.4576	0.4354
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Echinococcus granulosus	tyrosine protein kinase HCK	0.0049	0.1547	0.1201
Echinococcus multilocularis	activated cdc42 kinase 1	0.0049	0.1547	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0049	0.1547	0.1201
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.0039	0.0393	0.5
Trypanosoma brucei	Pseudokinase, putative	0.0049	0.1547	0.1663
Brugia malayi	protein-tyrosine kinase	0.0125	1	1
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0076	0.4576	0.3583
Trichomonas vaginalis	STE family protein kinase	0.0049	0.1547	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0076	0.4576	0.4354
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0076	0.4576	0.4354
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Loa Loa (eye worm)	TK/FER protein kinase	0.0125	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0049	0.1547	0.5
Brugia malayi	SRC-1	0.0125	1	1
Echinococcus granulosus	protein tyrosine kinase	0.0049	0.1547	0.1201
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4576	0.3583
Echinococcus multilocularis	tyrosine protein kinase csk	0.0049	0.1547	0.1201
Schistosoma mansoni	tyrosine kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	tyrosine protein kinase csk	0.0049	0.1547	0.1201
Trypanosoma cruzi	protein kinase, putative	0.0049	0.1547	0.4323
Echinococcus granulosus	tyrosine kinase	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.4576	0.3583
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0125	1	1
Mycobacterium ulcerans	pyruvate carboxylase	0.0039	0.0393	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5
Schistosoma mansoni	ephrin receptor	0.0049	0.1547	0.1201
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0049	0.1547	0.5
Schistosoma mansoni	protein kinase	0.0049	0.1547	0.1201
Echinococcus granulosus	tyrosine protein kinase Blk	0.0125	1	1
Echinococcus multilocularis	acetyl coenzyme A carboxylase 1	0.0101	0.7333	0.7224
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.4576	0.3583
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0049	0.1547	0.5
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0049	0.1547	0.1201
Trichomonas vaginalis	TKL family protein kinase	0.0049	0.1547	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3691134

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 2003074