TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 541.533 | Formula: C24H23N5O8S
H donors: 6 H acceptors: 10 LogP: 1.07 Rotable bonds: 10
Rule of 5 violations (Lipinski): 3
SMILES: OC(=O)CC[C@@H](C(=O)O)NC(=O)c1ccc(cc1)NS(=O)(=O)c1ccc2c(c1)c1c(O)nc(nc1CC2)N
InChi: 1S/C24H23N5O8S/c25-24-27-17-8-4-12-3-7-15(11-16(12)20(17)22(33)28-24)38(36,37)29-14-5-1-13(2-6-14)21(32)26-18(23(34)35)9-10-19(30)31/h1-3,5-7,11,18,29H,4,8-10H2,(H,26,32)(H,30,31)(H,34,35)(H3,25,27,28,33)/t18-/m0/s1
InChiKey: UCOXRAFKABNQQG-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	thymidylate synthetase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Cryptosporidium parvum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Babesia bovis	dihydrofolate reductase/thymidilate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium knowlesi	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Neospora caninum	Bifunctional dihydrofolate reductase-thymidylate synthase, related	Get druggable targets OG5_127385	All targets in OG5_127385
Loa Loa (eye worm)	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania donovani	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma brucei gambiense	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania mexicana	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus granulosus	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Brugia malayi	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania major	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Onchocerca volvulus		Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania infantum	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127385	All targets in OG5_127385
Theileria parva	dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Cryptosporidium hominis	chain A, crystal structure of Dhfr	Get druggable targets OG5_127385	All targets in OG5_127385
Leishmania braziliensis	dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium berghei	bifunctional dihydrofolate reductase-thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium yoelii	thymidylate synthase, putative	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium ulcerans	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Schistosoma japonicum	ko:K00560 thymidylate synthase [EC2.1.1.45], putative	Get druggable targets OG5_127385	All targets in OG5_127385
Echinococcus multilocularis	thymidylate synthase	Get druggable targets OG5_127385	All targets in OG5_127385
Candida albicans	Thymidylate synthase capable of functional substitution for S. cerevisiae CDC21 (YOR074C)	Get druggable targets OG5_127385	All targets in OG5_127385
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	Get druggable targets OG5_127385	All targets in OG5_127385

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	mitogen activated protein kinase 3	0.006	0.1129	0.0771
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0195	0.4702	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.1129	0.233
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0921	0.1884
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1129	0.3315
Trypanosoma brucei	metacaspase	0.0052	0.0921	0.1884
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0695	0.14
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0695	0.14
Schistosoma mansoni	caspase-3 (C14 family)	0.0137	0.3169	0.6448
Mycobacterium ulcerans	thymidylate synthase	0.0195	0.4702	1
Schistosoma mansoni	caspase-7 (C14 family)	0.0137	0.3169	0.6448
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0176	0.4208	0.895
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0195	0.4702	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.0697	0.0011
Trypanosoma brucei	protein kinase, putative	0.006	0.1129	0.233
Schistosoma mansoni	aryl hydrocarbon receptor	0.0057	0.1057	0.1553
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0043	0.0697	0.0717
Loa Loa (eye worm)	inositol-1	0.0043	0.0695	0.1479
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0043	0.0092
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0195	0.4702	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0195	0.4702	1
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0137	0.3169	0.2894
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0052	0.0921	0.0563
Brugia malayi	bHLH-PAS transcription factor	0.0042	0.0666	0.1418
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0043	0.0695	0.5
Brugia malayi	hypoxia-induced factor 1	0.0176	0.4208	0.895
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0052	0.0921	0.0563
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0697	0.1403
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0052	0.0921	0.0563
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.0697	0.0322
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.006	0.1129	0.233
Brugia malayi	intermediate filament protein	0.0032	0.0387	0.0823
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0921	0.1959
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0387	0.0823
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0695	0.14
Echinococcus multilocularis	tumor protein p63	0.0395	1	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0195	0.4702	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.006	0.1129	0.233
Echinococcus granulosus	caspase 8	0.0052	0.0921	0.0555
Echinococcus granulosus	caspase 3	0.0085	0.1802	0.1472
Mycobacterium ulcerans	putative regulatory protein	0.0042	0.0666	0.1338
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0137	0.3169	0.2894
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0043	0.0697	0.0322
Schistosoma mansoni	single-minded	0.0057	0.1057	0.1553
Trypanosoma brucei	metacaspase MCA2	0.0052	0.0921	0.1884
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.006	0.1129	0.233
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0093	0.2003	0.4206
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0195	0.4702	1
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0043	0.0697	0.0322
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0921	0.1884
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.0697	0.0322
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.1129	0.1719
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0697	0.1482
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0362	0.077
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0043	0.0092
Onchocerca volvulus		0.0195	0.4702	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1082	0.2302
Onchocerca volvulus	Cell death protein 3 homolog	0.01	0.2195	0.4189
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0921	0.1726
Echinococcus granulosus	caspase	0.0137	0.3169	0.2894
Echinococcus multilocularis	caspase 3	0.0085	0.1802	0.1472
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0195	0.4702	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.4599	0.9782
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1129	0.3315
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.1129	0.233
Schistosoma mansoni	hypothetical protein	0.0048	0.0827	0.102
Brugia malayi	hypothetical protein	0.0191	0.4599	0.9782
Echinococcus granulosus	apoptotic protease activating factor 1	0.0048	0.0827	0.0458
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.006	0.1129	0.233
Echinococcus multilocularis	thymidylate synthase	0.0195	0.4702	0.4488
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Onchocerca volvulus		0.0048	0.0827	0.102
Echinococcus granulosus	caspase 2	0.01	0.2195	0.188
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0697	0.0011
Echinococcus multilocularis	transfer RNA-Lys	0.0042	0.0666	0.0291
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0921	0.1726
Trypanosoma brucei	metacaspase MCA3	0.0052	0.0921	0.1884
Brugia malayi	PAS domain containing protein	0.0057	0.1057	0.2249
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.006	0.1129	0.233
Onchocerca volvulus		0.0058	0.1082	0.1611
Brugia malayi	thymidylate synthase	0.0195	0.4702	1
Echinococcus granulosus	mitogen activated protein kinase	0.006	0.1129	0.0771
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0362	0.077
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0372	0.0791
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0695	0.0714
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1129	0.3315
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0921	0.1884
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0052	0.0921	0.1237
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0043	0.0697	0.0717
Echinococcus multilocularis	mitogen activated protein kinase 3	0.006	0.1129	0.0771
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0387	0.0823
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.1129	0.3315
Brugia malayi	hypothetical protein	0.0048	0.0827	0.1759
Onchocerca volvulus		0.0042	0.0666	0.0648
Echinococcus multilocularis	caspase	0.0137	0.3169	0.2894
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0387	0.0823
Mycobacterium tuberculosis	Hypothetical protein	0.0093	0.2003	0.3458
Echinococcus multilocularis	apoptotic protease activating factor 1	0.0048	0.0827	0.0458
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0921	0.1726
Echinococcus multilocularis	caspase 8	0.0052	0.0921	0.0555
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0195	0.4702	1
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0921	0.1726
Brugia malayi	MAP kinase sur-1	0.006	0.1129	0.2401
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0827	0.1759
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0697	0.1403
Schistosoma mansoni	cellular tumor antigen P53	0.0058	0.1082	0.1611
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.0695	0.0321
Echinococcus granulosus	ubiquitin specific protease 41	0.0043	0.0697	0.0322
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.006	0.1129	0.2401
Trypanosoma brucei	metacaspase 5, putative	0.0052	0.0921	0.1884
Trypanosoma brucei	Metacaspase-4	0.0052	0.0921	0.1884
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0921	0.1726
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0043	0.0092
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0695	0.0714
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.0695	0.0321
Brugia malayi	hypothetical protein	0.0093	0.2003	0.4259
Echinococcus multilocularis	caspase 2	0.01	0.2195	0.188
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0043	0.0697	0.1482
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.006	0.1129	0.1082
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0052	0.0921	0.1959
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0043	0.0695	0.14
Leishmania major	metacaspase, putative	0.0052	0.0921	0.1884
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0043	0.0697	0.1403
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0043	0.0092
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.0697	0.1403
Trypanosoma cruzi	metacaspase, putative	0.0052	0.0921	0.1884
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0043	0.0697	1
Trichomonas vaginalis	conserved hypothetical protein	0.0093	0.2003	1
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0921	0.1726
Loa Loa (eye worm)	hypothetical protein	0.01	0.2195	0.4668
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0195	0.4702	1
Echinococcus granulosus	thymidylate synthase	0.0195	0.4702	0.4488
Echinococcus multilocularis	mitogen activated protein kinase	0.006	0.1129	0.0771
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0695	0.14
Echinococcus multilocularis	ubiquitin specific protease 41	0.0043	0.0697	0.0322
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.0697	0.0011
Giardia lamblia	Kinase, CMGC MAPK	0.006	0.1129	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Echinococcus granulosus	single minded 2	0.0042	0.0666	0.0291
Trypanosoma cruzi	metacaspase 5, putative	0.0052	0.0921	0.1884
Brugia malayi	Cell death protein 3 precursor	0.01	0.2195	0.4668
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0387	0.0823
Brugia malayi	Inositol-1	0.0043	0.0695	0.1479
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0043	0.0092
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0052	0.0921	0.1726
Trypanosoma cruzi	metacaspase 5, putative	0.0052	0.0921	0.1884
Schistosoma mansoni	caspase-7 (C14 family)	0.01	0.2195	0.4189
Loa Loa (eye worm)	thymidylate synthase	0.0195	0.4702	1

Activities

Activity type	Activity value	Assay description	Source	Reference
CCCT (functional)	= 0.65 uM	Cell culture cytotoxicity of MCF-7 breast adenocarcinoma cells	ChEMBL.	8230138
CCCT (functional)	= 0.65 uM	Cell culture cytotoxicity of MCF-7 breast adenocarcinoma cells	ChEMBL.	8230138
CCCT (functional)	= 2.4 uM	Cell culture cytotoxicity of MOLT-4 T-cell leukemia cells	ChEMBL.	8230138
CCCT (functional)	= 2.4 uM	Cell culture cytotoxicity of MOLT-4 T-cell leukemia cells	ChEMBL.	8230138
CCCT (functional)	= 7.9 uM	Cell culture cytotoxicity of SW480 colon adenocarcinoma cells	ChEMBL.	8230138
CCCT (functional)	= 7.9 uM	Cell culture cytotoxicity of SW480 colon adenocarcinoma cells	ChEMBL.	8230138
Ki (binding)	= 0.0025 uM	Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cells	ChEMBL.	8230138
Ki (binding)	= 0.0025 uM	Inhibition of purified human thymidylate synthase isolated from an E. coli harboring thy A gene cloned from SV40 transformed human fibroblast cells	ChEMBL.	8230138
Ki (functional)	= 42 uM	Inhibition constant against the transport of [3H]- methotrexate (MTX) by MOLT-4 T-cell	ChEMBL.	8230138
Ki (functional)	= 42 uM	Inhibition constant against the transport of [3H]- methotrexate (MTX) by MOLT-4 T-cell	ChEMBL.	8230138
Km (functional)	= 7 uM	Cytotoxicity constant for partially purified hog liver folylpolyglutamate synthetase (FPGS)	ChEMBL.	8230138
V/K (ADMET)	= 16.4	Ratio of relative velocity to that of the cytotoxicity constant	ChEMBL.	8230138
Vm rel (ADMET)	= 115 %	Velocity compared to a control 50 microM aminopterin run on each test	ChEMBL.	8230138

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL325972

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 202405