Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0026 | 0.0454 | 0.1404 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0045 | 0.0946 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 0.0946 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0011 | 0.0049 | 0.0049 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0045 | 0.0946 | 0.1277 |
Leishmania major | importin beta-1 subunit, putative | 0.0029 | 0.0526 | 0.266 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0011 | 0.0049 | 0.0049 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0026 | 0.0454 | 0.0454 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.0946 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0045 | 0.0946 | 0.0946 |
Echinococcus granulosus | geminin | 0.0173 | 0.4377 | 0.4377 |
Trichomonas vaginalis | esterase, putative | 0.0045 | 0.0946 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.0049 | 0.0049 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0373 | 0.0774 |
Onchocerca volvulus | 0.0045 | 0.0946 | 1 | |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0026 | 0.0454 | 0.0454 |
Mycobacterium ulcerans | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.019 | 0.4828 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0045 | 0.0946 | 0.1277 |
Mycobacterium ulcerans | lipase LipD | 0.0045 | 0.0946 | 0.196 |
Mycobacterium tuberculosis | Conserved protein | 0.0045 | 0.0946 | 0.1277 |
Echinococcus multilocularis | snurportin 1 | 0.0382 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0045 | 0.0946 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0045 | 0.0946 | 0.0946 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0454 | 0.1668 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0946 | 0.0902 |
Schistosoma mansoni | ran | 0.0026 | 0.0454 | 0.0454 |
Brugia malayi | beta-lactamase family protein | 0.0045 | 0.0946 | 0.3695 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0286 | 0.7409 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0045 | 0.0946 | 1 |
Mycobacterium tuberculosis | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.019 | 0.4828 | 0.6516 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0946 | 0.0902 |
Echinococcus multilocularis | geminin | 0.0173 | 0.4377 | 0.4377 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0373 | 0.0373 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0049 | 0.0049 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0011 | 0.0049 | 0.0049 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.0049 | 0.0049 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0011 | 0.0049 | 0.0049 |
Entamoeba histolytica | hypothetical protein | 0.0029 | 0.0526 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0036 | 0.0707 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0946 | 0.0902 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0011 | 0.0049 | 0.0049 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0373 | 0.0774 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0026 | 0.0454 | 0.1404 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0011 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | beta-lactamase | 0.0045 | 0.0946 | 0.0902 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0049 | 0.0049 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0029 | 0.0526 | 0.5557 |
Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0026 | 0.0454 | 0.1404 |
Onchocerca volvulus | 0.0045 | 0.0946 | 1 | |
Mycobacterium tuberculosis | Conserved protein | 0.0045 | 0.0946 | 0.1277 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0045 | 0.0946 | 0.0902 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0045 | 0.0946 | 0.1277 |
Plasmodium falciparum | importin beta, putative | 0.0036 | 0.0707 | 1 |
Onchocerca volvulus | 0.0045 | 0.0946 | 1 | |
Echinococcus multilocularis | importin subunit beta 1 | 0.0036 | 0.0707 | 0.0707 |
Toxoplasma gondii | ABC1 family protein | 0.0045 | 0.0946 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0946 | 0.0902 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0045 | 0.0946 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0045 | 0.0946 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0036 | 0.0707 | 0.0707 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0045 | 0.0946 | 0.196 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.0049 | 0.0049 |
Wolbachia endosymbiont of Brugia malayi | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.019 | 0.4828 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.0049 | 0.0049 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0011 | 0.0049 | 0.0049 |
Mycobacterium ulcerans | beta-lactamase | 0.0045 | 0.0946 | 0.196 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0045 | 0.0946 | 0.0946 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0036 | 0.0707 | 0.5831 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0707 | 0.0662 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0049 | 0.0049 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0045 | 0.0946 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0011 | 0.0049 | 0.0049 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0373 | 0.1337 |
Mycobacterium leprae | Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX | 0.019 | 0.4828 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0045 | 0.0946 | 0.196 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0454 | 0.0407 |
Plasmodium vivax | importin-beta 2, putative | 0.0036 | 0.0707 | 0.5831 |
Brugia malayi | beta-lactamase family protein | 0.0045 | 0.0946 | 0.3695 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0045 | 0.0946 | 0.1277 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0011 | 0.0049 | 0.0049 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0373 | 0.0373 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0946 | 0.0902 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0026 | 0.0447 | 0.1639 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | Conserved protein | 0.0045 | 0.0946 | 0.1277 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0036 | 0.0707 | 0.5831 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0026 | 0.0454 | 0.1404 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0373 | 0.0326 |
Leishmania major | GTP-binding protein, putative | 0.0026 | 0.0454 | 0.1404 |
Mycobacterium leprae | Probable lipase LipE | 0.0045 | 0.0946 | 0.196 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0447 | 0.04 |
Trichomonas vaginalis | importin beta-1, putative | 0.0029 | 0.0526 | 0.5557 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0373 | 0.2225 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.0049 | 0.0049 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.0049 | 0.0049 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.0049 | 0.0049 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0036 | 0.0707 | 0.5831 |
Brugia malayi | Importin beta-1 subunit | 0.0036 | 0.0707 | 0.2712 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0045 | 0.0946 | 0.196 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0045 | 0.0946 | 0.0946 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0373 | 0.0504 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0018 | 0.0225 | 0.0728 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0045 | 0.0946 | 0.1277 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.0049 | 0.0049 |
Treponema pallidum | phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) | 0.0072 | 0.1678 | 1 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0026 | 0.0454 | 0.1404 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.0049 | 0.0049 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0454 | 1 |
Chlamydia trachomatis | phospho-N-acetylmuramoyl-pentapeptide-transferase | 0.0072 | 0.1678 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0045 | 0.0946 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0946 | 0.0902 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0373 | 0.0373 |
Brugia malayi | beta-lactamase | 0.0045 | 0.0946 | 0.3695 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0026 | 0.0447 | 0.04 |
Schistosoma mansoni | ran | 0.0026 | 0.0454 | 0.0454 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4377 | 0.4377 |
Trichomonas vaginalis | ran, putative | 0.0026 | 0.0454 | 0.4797 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0373 | 0.0373 |
Echinococcus granulosus | FTZ F1 alpha | 0.0011 | 0.0049 | 0.0049 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0045 | 0.0946 | 0.3695 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0029 | 0.0526 | 0.5557 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0011 | 0.0049 | 0.0049 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.4377 | 0.4377 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0011 | 0.0049 | 0.0049 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0373 | 0.3947 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0225 | 0.0178 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0045 | 0.0946 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0029 | 0.0526 | 0.266 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0026 | 0.0447 | 0.1639 |
Mycobacterium leprae | conserved hypothetical protein | 0.0045 | 0.0946 | 0.196 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.0049 | 0.0049 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0045 | 0.0946 | 0.1277 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.0049 | 0.0049 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0373 | 0.3947 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0454 | 0.2408 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0225 | 0.0225 |
Entamoeba histolytica | Ran family GTPase | 0.0026 | 0.0454 | 0.5279 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0045 | 0.0946 | 0.1277 |
Brugia malayi | RNA, U transporter 1 | 0.0102 | 0.2478 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0011 | 0.0049 | 0.0049 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.