Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | calpain 1, (mu/I) large subunit | References | |
Homo sapiens | calpain 2, (m/II) large subunit | Starlite/ChEMBL | References |
Homo sapiens | calpain, small subunit 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | calpain A | calpain 1, (mu/I) large subunit | 714 aa | 753 aa | 31.7 % |
Echinococcus granulosus | calpain A | calpain 2, (m/II) large subunit | 622 aa | 663 aa | 31.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 0.1626 | 0.1935 |
Schistosoma mansoni | peroxidasin | 0.0104 | 0.1626 | 0.1626 |
Echinococcus multilocularis | sodium:glucose cotransporter 2 | 0.0075 | 0.0762 | 0.0906 |
Brugia malayi | Blistered cuticle protein 3 | 0.0104 | 0.1626 | 0.1935 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0104 | 0.1626 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0104 | 0.1626 | 0.1935 |
Schistosoma mansoni | inositol transporter | 0.0075 | 0.0762 | 0.0762 |
Echinococcus granulosus | high affinity choline transporter 1 | 0.0075 | 0.0762 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0332 | 0.8402 | 1 |
Toxoplasma gondii | cathepsin B | 0.0109 | 0.1782 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 0.1626 | 0.1935 |
Echinococcus granulosus | sodium:myo inositol cotransporter | 0.0075 | 0.0762 | 0.0906 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0142 | 0.2738 | 0.2738 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0109 | 0.1782 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Onchocerca volvulus | Peroxidasin homolog | 0.0104 | 0.1626 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Echinococcus multilocularis | sodium coupled monocarboxylate transporter 1 | 0.0075 | 0.0762 | 0.0906 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 0.1626 | 0.1935 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0142 | 0.2738 | 0.3259 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1997 | 0.2377 |
Echinococcus multilocularis | peroxidasin | 0.0104 | 0.1626 | 0.1935 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0132 | 0.2442 | 0.2442 |
Onchocerca volvulus | 0.0104 | 0.1626 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0109 | 0.1782 | 0.5 |
Schistosoma mansoni | sodium/solute symporter | 0.0075 | 0.0762 | 0.0762 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0332 | 0.8402 | 0.8402 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0097 | 0.1408 | 0.1675 |
Schistosoma mansoni | high-affinity choline transporter | 0.0075 | 0.0762 | 0.0762 |
Echinococcus multilocularis | solute carrier family 5 | 0.0075 | 0.0762 | 0.0906 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 0.1626 | 0.1935 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0142 | 0.2738 | 0.2738 |
Onchocerca volvulus | 0.0104 | 0.1626 | 1 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 0.1626 | 0.1935 |
Brugia malayi | GH02984p | 0.0075 | 0.0762 | 0.0906 |
Plasmodium vivax | calpain, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0097 | 0.1408 | 0.1675 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Brugia malayi | Peroxidasin | 0.0104 | 0.1626 | 0.1935 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.2442 | 0.2906 |
Schistosoma mansoni | inositol transporter | 0.0075 | 0.0762 | 0.0762 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0762 | 0.0906 |
Echinococcus granulosus | calpain A | 0.0142 | 0.2746 | 0.3269 |
Onchocerca volvulus | 0.0082 | 0.0963 | 0.2328 | |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0109 | 0.1782 | 0.2121 |
Giardia lamblia | Cathepsin B precursor | 0.0109 | 0.1782 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0104 | 0.1626 | 0.1935 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0109 | 0.1782 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0104 | 0.1626 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0963 | 0.1146 |
Echinococcus multilocularis | cathepsin b | 0.0332 | 0.8402 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Giardia lamblia | Cathepsin B precursor | 0.0109 | 0.1782 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0104 | 0.1626 | 1 |
Echinococcus multilocularis | high affinity choline transporter 1 | 0.0075 | 0.0762 | 0.0906 |
Echinococcus multilocularis | sodium:myo inositol cotransporter | 0.0075 | 0.0762 | 0.0906 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Echinococcus granulosus | sodium:glucose cotransporter | 0.0075 | 0.0762 | 0.0906 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0109 | 0.1782 | 0.1782 |
Onchocerca volvulus | 0.0104 | 0.1626 | 1 | |
Brugia malayi | calpain family protein 1 | 0.0132 | 0.2442 | 0.2906 |
Onchocerca volvulus | Peroxidase homolog | 0.0104 | 0.1626 | 1 |
Echinococcus granulosus | peroxidasin | 0.0104 | 0.1626 | 0.1935 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.0762 | 0.0906 |
Echinococcus granulosus | sodium coupled monocarboxylate transporter 1 | 0.0075 | 0.0762 | 0.0906 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 0.1626 | 0.1935 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0142 | 0.2738 | 0.3259 |
Schistosoma mansoni | peroxidasin | 0.0104 | 0.1626 | 0.1626 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 0.1626 | 0.1935 |
Brugia malayi | Sodium:solute symporter family protein | 0.0075 | 0.0762 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0332 | 0.8402 | 1 |
Brugia malayi | calpain family protein 1 | 0.0132 | 0.2442 | 0.2906 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Echinococcus granulosus | solute carrier family 5 | 0.0075 | 0.0762 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Giardia lamblia | Cathepsin B precursor | 0.0109 | 0.1782 | 0.5 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0332 | 0.8402 | 0.8402 |
Echinococcus multilocularis | cathepsin b | 0.0332 | 0.8402 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0332 | 0.8402 | 0.8402 |
Loa Loa (eye worm) | hypothetical protein | 0.0332 | 0.8402 | 1 |
Echinococcus granulosus | cathepsin b | 0.0332 | 0.8402 | 1 |
Echinococcus granulosus | cathepsin b | 0.0332 | 0.8402 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0109 | 0.1782 | 0.2121 |
Echinococcus granulosus | sodium:glucose cotransporter 2 | 0.0075 | 0.0762 | 0.0906 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0332 | 0.8402 | 0.8402 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1408 | 0.1675 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1626 | 0.1935 |
Onchocerca volvulus | Peroxidasin homolog | 0.0104 | 0.1626 | 1 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0132 | 0.2442 | 0.2906 |
Brugia malayi | Animal haem peroxidase family protein | 0.0104 | 0.1626 | 0.1935 |
Echinococcus multilocularis | calpain A | 0.0142 | 0.2746 | 0.3269 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 27 uM | Inhibitory potency against rat platelet membrane permeability at pH 7.35 | ChEMBL. | 8230139 |
Ki (binding) | = 0.059 uM | Inhibitory activity of alpha-keto esters towards calpain 2 at pH 8.0 | ChEMBL. | 8230139 |
Ki (binding) | = 0.059 uM | Inhibitory activity of alpha-keto esters towards calpain 2 at pH 8.0 | ChEMBL. | 8230139 |
Ki (binding) | = 0.32 uM | Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0. | ChEMBL. | 8230139 |
Ki (binding) | = 0.32 uM | Inhibitory activity of alpha-keto esters towards calpain 1 at pH 8.0. | ChEMBL. | 8230139 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.