Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 331 aa | 25.7 % |
Echinococcus granulosus | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 304 aa | 25.3 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Adenosine A1 receptor | 326 aa | 318 aa | 22.3 % |
Schistosoma japonicum | 5-hydroxytryptamine receptor 4, putative | Adenosine A1 receptor | 326 aa | 301 aa | 25.6 % |
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 277 aa | 23.8 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A1 receptor | 326 aa | 296 aa | 22.6 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 307 aa | 21.2 % | |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 326 aa | 20.2 % | |
Schistosoma mansoni | neuropeptide receptor | Adenosine A1 receptor | 326 aa | 314 aa | 21.7 % |
Brugia malayi | hypothetical protein | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % |
Loa Loa (eye worm) | neuropeptide F receptor | Adenosine A1 receptor | 326 aa | 316 aa | 19.3 % |
Onchocerca volvulus | Adenosine A1 receptor | 326 aa | 311 aa | 21.9 % | |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 22.1 % |
Schistosoma mansoni | opsin-like receptor | Adenosine A1 receptor | 326 aa | 315 aa | 23.8 % |
Echinococcus multilocularis | allatostatin A receptor | Adenosine A1 receptor | 326 aa | 306 aa | 26.1 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Adenosine A1 receptor | 326 aa | 312 aa | 24.0 % |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Adenosine A1 receptor | 326 aa | 286 aa | 22.7 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.2104 | 0.6029 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3355 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1472 | 0.4022 | 0.3961 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1166 | 0.3052 | 0.5431 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1472 | 0.4022 | 0.3961 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1472 | 0.4022 | 0.3763 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1948 | 0.5535 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1472 | 0.4022 | 0.3961 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2886 | 0.8512 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1472 | 0.4022 | 0.3961 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2886 | 0.8512 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1472 | 0.4022 | 0.3961 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1472 | 0.4022 | 0.3961 |
Echinococcus multilocularis | carbonic anhydrase II | 0.3355 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1472 | 0.4022 | 0.3961 |
Leishmania major | carbonic anhydrase family protein, putative | 0.2104 | 0.6029 | 0.5905 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1472 | 0.4022 | 0.3763 |
Plasmodium falciparum | carbonic anhydrase | 0.1472 | 0.4022 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.2104 | 0.6029 | 0.5857 |
Mycobacterium ulcerans | carbonic anhydrase | 0.2886 | 0.8512 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.3355 | 1 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.2104 | 0.6029 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.3355 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3355 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.3355 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.3355 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1472 | 0.4022 | 0.3961 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1472 | 0.4022 | 0.3763 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.1174 | 0.3077 | 0.5478 |
Echinococcus multilocularis | geminin | 0.0335 | 0.0415 | 0.0316 |
Echinococcus multilocularis | carbonic anhydrase | 0.1472 | 0.4022 | 0.3961 |
Schistosoma mansoni | carbonic anhydrase | 0.1472 | 0.4022 | 0.3763 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.3355 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1472 | 0.4022 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1472 | 0.4022 | 0.3961 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1472 | 0.4022 | 0.3961 |
Echinococcus granulosus | carbonic anhydrase | 0.1472 | 0.4022 | 0.3961 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.3355 | 1 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0205 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1472 | 0.4022 | 0.3961 |
Loa Loa (eye worm) | hypothetical protein | 0.2064 | 0.5902 | 0.586 |
Onchocerca volvulus | 0.0205 | 0 | 0.5 | |
Leishmania major | carbonic anhydrase-like protein | 0.3355 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1472 | 0.4022 | 0.3961 |
Echinococcus granulosus | geminin | 0.0335 | 0.0415 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.1472 | 0.4022 | 0.3763 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.3355 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 27 % | Percentage inhibition of [3H]CGS 21680 binding to adenosine A2A receptor in bovine striatal membranes at 20 uM | ChEMBL. | 16335918 |
Inhibition (binding) | = 27 % | Percentage inhibition of [3H]CGS 21680 binding to adenosine A2A receptor in bovine striatal membranes at 20 uM | ChEMBL. | 16335918 |
Ki (binding) | = 82 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16335918 |
Ki (binding) | = 82 nM | Displacement of [125I]AB-MECA from human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16335918 |
Ki (binding) | = 205 nM | Displacement of [3H]CHA from cloned human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16335918 |
Ki (binding) | = 205 nM | Displacement of [3H]CHA from cloned human adenosine A1 receptor expressed in CHO cells | ChEMBL. | 16335918 |
Ki (binding) | = 578 nM | Displacement of [3H]CHA from adenosine A1 receptor in bovine cerebral cortical membranes | ChEMBL. | 16335918 |
Ki (binding) | = 578 nM | Displacement of [3H]CHA from adenosine A1 receptor in bovine cerebral cortical membranes | ChEMBL. | 16335918 |
Ratio Ki (binding) | = 2.5 | Selectivity for human adenosine A3 receptor over human adenosine A1 receptor | ChEMBL. | 16335918 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.