Detailed information for compound 204683

Basic information

Technical information
  • TDR Targets ID: 204683
  • Name: benzyl (2S)-2-[(2S)-2-(thiophene-2-carbonyl)p yrrolidine-1-carbonyl]pyrrolidine-1-carboxyla te
  • MW: 412.502 | Formula: C22H24N2O4S
  • H donors: 0 H acceptors: 3 LogP: 3.62 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)c1cccs1)OCc1ccccc1
  • InChi: 1S/C22H24N2O4S/c25-20(19-11-6-14-29-19)17-9-4-12-23(17)21(26)18-10-5-13-24(18)22(27)28-15-16-7-2-1-3-8-16/h1-3,6-8,11,14,17-18H,4-5,9-10,12-13,15H2/t17-,18-/m0/s1
  • InChiKey: ZXARNOMYATZGQP-ROUUACIJSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[oxo-[(2S)-2-[oxo(2-thienyl)methyl]-1-pyrrolidinyl]methyl]-1-pyrrolidinecarboxylic acid benzyl ester
  • phenylmethyl (2S)-2-[(2S)-2-thiophen-2-ylcarbonylpyrrolidin-1-yl]carbonylpyrrolidine-1-carboxylate
  • (2S)-2-[(2S)-2-(2-thenoyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylic acid benzyl ester
  • phenylmethyl (2S)-2-[(2S)-2-(thiophene-2-carbonyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
  • (2S)-2-[oxo-[(2S)-2-[oxo-(2-thienyl)methyl]-1-pyrrolidinyl]methyl]-1-pyrrolidinecarboxylic acid phenylmethyl ester
  • (2S)-2-[(2S)-2-(thiophene-2-carbonyl)pyrrolidine-1-carbonyl]pyrrolidine-1-carboxylic acid benzyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Sus scrofa Prolyl endopeptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) Get druggable targets OG5_129295 All targets in OG5_129295
Neospora caninum Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus granulosus prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Toxoplasma gondii prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Echinococcus multilocularis prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma cruzi prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania donovani prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma congolense prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania infantum prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma mansoni prolyl oligopeptidase (S09 family) Get druggable targets OG5_129295 All targets in OG5_129295
Onchocerca volvulus Prolyl endopeptidase homolog Get druggable targets OG5_129295 All targets in OG5_129295
Leishmania mexicana prolyl oligopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei prolyl endopeptidase Get druggable targets OG5_129295 All targets in OG5_129295
Trypanosoma brucei gambiense prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative Get druggable targets OG5_129295 All targets in OG5_129295
Schistosoma japonicum Prolyl endopeptidase, putative Get druggable targets OG5_129295 All targets in OG5_129295
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi oligopeptidase b Prolyl endopeptidase   710 aa 719 aa 25.6 %
Trypanosoma cruzi oligopeptidase b Prolyl endopeptidase   710 aa 719 aa 25.6 %
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) Prolyl endopeptidase   710 aa 741 aa 25.6 %
Leishmania braziliensis oligopeptidase b;with=GeneDB:LmjF09.0770 Prolyl endopeptidase   710 aa 608 aa 26.0 %
Dictyostelium discoideum oligopeptidase B Prolyl endopeptidase   710 aa 735 aa 23.7 %
Trypanosoma brucei gambiense oligopeptidase B, putative Prolyl endopeptidase   710 aa 629 aa 26.4 %
Leishmania major oligopeptidase b Prolyl endopeptidase   710 aa 743 aa 24.9 %
Leishmania mexicana oligopeptidase b,serine peptidase, clan SC, family S9A-like protein Prolyl endopeptidase   710 aa 720 aa 24.7 %
Leishmania donovani oligopeptidase b Prolyl endopeptidase   710 aa 743 aa 24.4 %
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB Prolyl endopeptidase   710 aa 714 aa 26.5 %
Trypanosoma congolense oligopeptidase b Prolyl endopeptidase   710 aa 589 aa 27.8 %
Trypanosoma brucei oligopeptidase b Prolyl endopeptidase   710 aa 630 aa 26.3 %
Leishmania infantum oligopeptidase b;with=GeneDB:LmjF09.0770 Prolyl endopeptidase   710 aa 743 aa 24.4 %
Onchocerca volvulus Prolyl endopeptidase   710 aa 722 aa 47.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0086 0.2213 0.3283
Echinococcus multilocularis g protein coupled receptor 0.0093 0.2437 0.3618
Trypanosoma brucei prolyl endopeptidase 0.0158 0.4627 1
Schistosoma mansoni biogenic amine receptor 0.0093 0.2437 0.3631
Echinococcus granulosus tachykinin peptides receptor 99D 0.0093 0.2437 0.3618
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.2981 0.444
Brugia malayi neuropeptide F receptor 0.0093 0.2437 0.5153
Echinococcus multilocularis neuropeptide receptor A26 0.0093 0.2437 0.3618
Onchocerca volvulus 0.0093 0.2437 0.5254
Brugia malayi RE15519p 0.0093 0.2437 0.5153
Echinococcus multilocularis orexin receptor type 2 0.0093 0.2437 0.3618
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2981 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.1038 0.1529
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0566 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis g protein coupled receptor 0.0093 0.2437 0.3618
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0161 0.4718 0.7021
Schistosoma mansoni hypothetical protein 0.0093 0.2437 0.3631
Brugia malayi G protein-coupled receptor F59B2.13 0.0093 0.2437 0.5153
Onchocerca volvulus 0.0093 0.2437 0.5254
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.1038 0.1162
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0161 0.4718 0.7021
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.2953 0.6925
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0311 0.0818
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Brugia malayi 6-phosphofructokinase 0.0109 0.2981 0.6308
Onchocerca volvulus 0.0093 0.2437 0.5254
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0036 0.0539 0.0785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0914 0.1316
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0063 0.1432 0.2133
Trypanosoma brucei prolyl oligopeptidase, putative 0.0063 0.1432 0.2133
Brugia malayi G-protein coupled receptor 0.0093 0.2437 0.5153
Loa Loa (eye worm) hypothetical protein 0.022 0.6713 0.6709
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Onchocerca volvulus 0.0093 0.2437 0.5254
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0093 0.2437 0.3618
Loa Loa (eye worm) glutathione reductase 0.0047 0.0914 0.0902
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0566 0.0954
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0063 0.1432 0.3587
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Leishmania major trypanothione reductase 0.0047 0.0914 0.0858
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Echinococcus granulosus peptide allatostatin:somatostatin 0.0093 0.2437 0.3618
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0145 0.4192 0.6236
Schistosoma mansoni histamine h1 receptor 0.0093 0.2437 0.3631
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.1038 0.1162
Brugia malayi phosphofructokinase 0.0109 0.2981 0.6308
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.1038 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.2437 0.3631
Trypanosoma cruzi oligopeptidase b 0.0063 0.1432 0.2133
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.1038 0.1683
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0161 0.4718 0.7021
Plasmodium falciparum thioredoxin reductase 0.0047 0.0914 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.2981 0.5947
Brugia malayi Thioredoxin reductase 0.0047 0.0914 0.1915
Echinococcus granulosus neuropeptide s receptor 0.0093 0.2437 0.3618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2981 1
Brugia malayi glutathione reductase 0.0047 0.0914 0.1915
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.2721
Schistosoma mansoni biogenic amine receptor 0.0093 0.2437 0.3631
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.2437 0.3618
Brugia malayi GnHR receptor homolog 0.0093 0.2437 0.5153
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Brugia malayi Serotonin receptor 0.0093 0.2437 0.5153
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.2437 0.3618
Echinococcus granulosus sex peptide receptor 0.0093 0.2437 0.3618
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0032 0.0388 0.0375
Echinococcus granulosus neuropeptide FF receptor 2 0.0093 0.2437 0.3618
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.3358 0.8039
Echinococcus granulosus fmrfamide receptor 0.0093 0.2437 0.3618
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2981 0.8155
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus granulosus somatostatin receptor 0.0093 0.2437 0.3618
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.2953 0.6925
Schistosoma mansoni nck2/grb4 0.0032 0.0388 0.0578
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0093 0.2437 0.3631
Echinococcus multilocularis G-protein coupled receptor, putative 0.0093 0.2437 0.3618
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0063 0.1432 0.2133
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 0.4718 0.7021
Loa Loa (eye worm) phosphofructokinase 0.0109 0.2981 0.2972
Schistosoma mansoni growth hormone secretagogue receptor 0.0093 0.2437 0.3631
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.2437 0.3618
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.1038 0.1026
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0161 0.4718 0.7021
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0086 0.2213 0.3283
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Entamoeba histolytica protein kinase, putative 0.0129 0.3652 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.2437 0.3618
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0566 0.0954
Brugia malayi Dopamine receptor protein 2 0.0093 0.2437 0.5153
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.2437 0.2427
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.2437 0.3618
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0142 0.4071 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0161 0.4718 0.7021
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0161 0.4718 0.7021
Echinococcus granulosus g protein coupled receptor 0.0093 0.2437 0.3618
Echinococcus multilocularis serotonin receptor 0.022 0.6713 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0093 0.2437 0.3631
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.2437 0.3618
Schistosoma mansoni amine GPCR 0.0093 0.2437 0.3631
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis fmrfamide receptor 0.0093 0.2437 0.3618
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.2981 0.2972
Echinococcus granulosus 7TM GPCR rhodopsin 0.0093 0.2437 0.3618
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0388 0.0796
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Schistosoma mansoni tyrosine kinase 0.0036 0.0539 0.0803
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0093 0.2437 0.3618
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Schistosoma mansoni myosin xvIII 0.0093 0.2437 0.3631
Echinococcus granulosus neuropeptides capa receptor 0.0093 0.2437 0.3618
Echinococcus granulosus orexin receptor type 2 0.0093 0.2437 0.3618
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0093 0.2437 0.3631
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0566 0.0954
Mycobacterium tuberculosis Probable reductase 0.0108 0.2953 0.6925
Brugia malayi Sex muscle abnormal protein 5 0.0032 0.0388 0.0796
Echinococcus multilocularis tyrosine protein kinase HCK 0.0129 0.3652 0.5431
Echinococcus multilocularis dro:myosuppressin receptor 0.0093 0.2437 0.3618
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0093 0.2437 0.2427
Onchocerca volvulus 0.0093 0.2437 0.5254
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Toxoplasma gondii prolyl endopeptidase 0.0158 0.4627 1
Onchocerca volvulus 0.0093 0.2437 0.5254
Echinococcus granulosus neuropeptide Y receptor 0.0093 0.2437 0.3618
Echinococcus multilocularis neuropeptide FF receptor 2 0.0093 0.2437 0.3618
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0086 0.2213 0.4676
Loa Loa (eye worm) neuropeptide F receptor 0.0093 0.2437 0.2427
Echinococcus granulosus g-protein coupled receptor 0.0093 0.2437 0.3618
Schistosoma mansoni amine GPCR 0.0093 0.2437 0.3631
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus granulosus NCK adaptor protein 0.0032 0.0388 0.0559
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.2437 0.3618
Schistosoma mansoni tyrosine kinase 0.0161 0.4718 0.7027
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.2981 0.5947
Brugia malayi Serotonin receptor 0.0093 0.2437 0.5153
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0093 0.2437 0.3618
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0093 0.2437 0.5153
Schistosoma mansoni neuropeptide receptor 0.0093 0.2437 0.3631
Schistosoma mansoni amine GPCR 0.0093 0.2437 0.3631
Echinococcus granulosus biogenic amine 5HT receptor 0.0093 0.2437 0.3618
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0032 0.0388 0.0375
Leishmania major oligopeptidase b 0.0063 0.1432 0.2133
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2981 1
Brugia malayi putative neuropeptide receptor 0.0093 0.2437 0.5153
Brugia malayi Dopamine receptor 0.0093 0.2437 0.5153
Loa Loa (eye worm) melatonin receptor type 1A 0.0093 0.2437 0.2427
Onchocerca volvulus 0.0093 0.2437 0.5254
Brugia malayi follicle stimulating hormone receptor 0.0093 0.2437 0.5153
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0161 0.4718 0.7021
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0158 0.4627 1
Onchocerca volvulus Putative nachr subunit 0.0086 0.2213 0.4768
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0093 0.2437 0.3618
Onchocerca volvulus Prolyl endopeptidase homolog 0.0158 0.4627 1
Onchocerca volvulus 0.0093 0.2437 0.5254
Echinococcus granulosus 7tm_1 domain containing protein 0.0093 0.2437 0.3618
Schistosoma mansoni tyrosine kinase 0.0021 0.0013 0.002
Schistosoma mansoni hypothetical protein 0.0093 0.2437 0.3631
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.2981 0.7002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.2953 0.8614
Schistosoma mansoni alpha-1 adrenergic receptor 0.0093 0.2437 0.3631
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0093 0.2437 0.3618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.1038 0.1529
Schistosoma mansoni neuropeptide receptor 0.0093 0.2437 0.3631
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0055 0.1181 0.1742
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0093 0.2437 0.3618
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.2981 0.4429
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.2981 0.444
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0914 0.0902
Echinococcus multilocularis serotonin receptor 0.022 0.6713 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0036 0.0539 0.0785
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0093 0.2437 0.3631
Echinococcus multilocularis prolyl endopeptidase 0.0158 0.4627 0.6886
Brugia malayi G protein-coupled receptor 0.0093 0.2437 0.5153
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0093 0.2437 0.5153
Echinococcus multilocularis neuropeptide receptor 0.0093 0.2437 0.3618
Brugia malayi larval opioid receptor 0.0093 0.2437 0.5153
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0093 0.2437 0.5153
Loa Loa (eye worm) TYRA-2 protein 0.0093 0.2437 0.2427
Echinococcus multilocularis neuropeptide receptor 0.0093 0.2437 0.3618
Schistosoma mansoni tyrosine kinase 0.0161 0.4718 0.7027
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0093 0.2437 0.3618
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Echinococcus granulosus tyrosine protein kinase Blk 0.0145 0.4192 0.6236
Echinococcus granulosus c src tyrosine kinase 0.0036 0.0539 0.0785
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.2721
Schistosoma mansoni adenoreceptor 0.0093 0.2437 0.3631
Schistosoma mansoni opsin-like receptor 0.0093 0.2437 0.3631
Schistosoma mansoni inositol monophosphatase 0.0037 0.0566 0.0843
Brugia malayi ORL1-like opioid receptor 0.0093 0.2437 0.5153
Echinococcus multilocularis NCK adaptor protein 0.0032 0.0388 0.0559
Echinococcus granulosus tyrosine protein kinase Fyn 0.0161 0.4718 0.7021
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0093 0.2437 0.3618
Echinococcus multilocularis fmrfamide receptor 0.0093 0.2437 0.3618
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0914 0.0858
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0311 0.5
Plasmodium falciparum glutathione reductase 0.0047 0.0914 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0093 0.2437 0.3618
Echinococcus granulosus allatostatin A receptor 0.0093 0.2437 0.3618
Schistosoma mansoni opsin-like receptor 0.0093 0.2437 0.3631
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Echinococcus granulosus tyrosine protein kinase HCK 0.0129 0.3652 0.5431
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.2721
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Loa Loa (eye worm) TK protein kinase 0.0129 0.3652 0.3644
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.2981 0.2972
Schistosoma mansoni amine GPCR 0.0093 0.2437 0.3631
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0093 0.2437 0.3631
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.2953 0.6925
Echinococcus granulosus hypothetical protein 0.0093 0.2437 0.3618
Brugia malayi sulfakinin receptor protein 0.0093 0.2437 0.5153
Trypanosoma cruzi prolyl endopeptidase 0.0158 0.4627 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Onchocerca volvulus 0.0093 0.2437 0.5254
Brugia malayi Tyrosine-protein kinase abl-1 0.0036 0.0539 0.1118
Brugia malayi MAP kinase sur-1 0.0051 0.1038 0.2177
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0566 0.0824
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0086 0.2213 0.3283
Trypanosoma brucei protein kinase, putative 0.0051 0.1038 0.1162
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0093 0.2437 0.5153
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0161 0.4718 0.7021
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.2437 0.3631
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0914 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.1038 0.1162
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis c src tyrosine kinase 0.0036 0.0539 0.0785
Schistosoma mansoni tyrosine kinase 0.0021 0.0013 0.002
Brugia malayi Variant SH3 domain containing protein 0.0032 0.0388 0.0796
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.2437 0.3618
Schistosoma mansoni biogenic amine (5HT) receptor 0.0093 0.2437 0.3631
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.2437 0.3631
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Onchocerca volvulus 0.0093 0.2437 0.5254
Brugia malayi Melatonin receptor type 1A 0.0093 0.2437 0.5153
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1038 0.1162
Brugia malayi Dopamine receptor protein 1 0.0093 0.2437 0.5153
Schistosoma mansoni amine GPCR 0.0093 0.2437 0.3631
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.2981 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0914 0.1344
Echinococcus multilocularis g-protein coupled receptor 0.0093 0.2437 0.3618
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.3358 0.8039
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0086 0.2213 0.3283
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0032 0.0388 0.0578
Echinococcus granulosus neuropeptide receptor 0.0093 0.2437 0.3618
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Loa Loa (eye worm) hypothetical protein 0.0158 0.4627 0.462
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Onchocerca volvulus 0.0093 0.2437 0.5254
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0093 0.2437 0.3631
Trypanosoma cruzi oligopeptidase b 0.0063 0.1432 0.2133
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Onchocerca volvulus 0.0093 0.2437 0.5254
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.2437 0.3618
Loa Loa (eye worm) TK protein kinase 0.0145 0.4192 0.4184
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.2437 0.3618
Echinococcus multilocularis tyrosine protein kinase Srms 0.0145 0.4192 0.6236
Loa Loa (eye worm) hypothetical protein 0.0032 0.0388 0.0375
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Echinococcus granulosus tyrosine protein kinase Fyn 0.0161 0.4718 0.7021
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0086 0.2213 0.3283
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Echinococcus granulosus tyrosine protein kinase Fyn 0.0161 0.4718 0.7021
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0093 0.2437 0.3618
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Plasmodium vivax glutathione reductase, putative 0.0047 0.0914 1
Brugia malayi Inositol-1 0.0037 0.0566 0.1174
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1038 0.1546
Trypanosoma brucei trypanothione reductase 0.0047 0.0914 0.0858
Brugia malayi hypothetical protein 0.0122 0.3419 0.7241
Mycobacterium tuberculosis Probable peptidase 0.0063 0.1432 0.2742
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.3358 0.8039
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Schistosoma mansoni growth factor receptor-bound protein 0.0032 0.0388 0.0578
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.1038 0.2721
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0093 0.2437 0.5254
Echinococcus multilocularis neuropeptides capa receptor 0.0093 0.2437 0.3618
Onchocerca volvulus 0.0093 0.2437 0.5254
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 0.4718 0.7021
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0311 0.5
Schistosoma mansoni inositol monophosphatase 0.0037 0.0566 0.0843
Brugia malayi AKH receptor 0.0093 0.2437 0.5153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Schistosoma mansoni neuropeptide f receptor 76f 0.0093 0.2437 0.3631
Schistosoma mansoni hypothetical protein 0.0093 0.2437 0.3631
Toxoplasma gondii thioredoxin reductase 0.0047 0.0914 0.1397
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0093 0.2437 0.3618
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0145 0.4192 0.6236
Onchocerca volvulus 0.0093 0.2437 0.5254
Echinococcus multilocularis sex peptide receptor 0.0093 0.2437 0.3618
Brugia malayi 6-phosphofructokinase 0.0109 0.2981 0.6308
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.1038 0.1529
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0093 0.2437 0.2427
Schistosoma mansoni hypothetical protein 0.0093 0.2437 0.3631
Echinococcus multilocularis neuropeptide Y receptor 0.0093 0.2437 0.3618
Onchocerca volvulus Neuropeptide F receptor homolog 0.0093 0.2437 0.5254
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0036 0.0539 0.0803
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Onchocerca volvulus 0.0093 0.2437 0.5254
Echinococcus granulosus biogenic amine 5HT receptor 0.022 0.6713 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0093 0.2437 0.5153
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0093 0.2437 0.5153
Brugia malayi prolyl oligopeptidase family protein 0.0158 0.4627 0.9808
Echinococcus granulosus tyrosine protein kinase Src64B 0.0161 0.4718 0.7021
Onchocerca volvulus 0.0093 0.2437 0.5254
Brugia malayi G-protein coupled receptor 0.0093 0.2437 0.5153
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0093 0.2437 0.2427
Echinococcus granulosus neuropeptide receptor 0.0093 0.2437 0.3618
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0093 0.2437 0.3631
Echinococcus granulosus G protein coupled receptor 139 0.0093 0.2437 0.3618
Echinococcus multilocularis G protein coupled receptor 139 0.0093 0.2437 0.3618
Echinococcus multilocularis growth factor receptor bound protein 2 0.0032 0.0388 0.0559
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.2981 0.4429
Echinococcus multilocularis neuropeptide s receptor 0.0093 0.2437 0.3618
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.4627 0.6893
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0093 0.2437 0.2427
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Schistosoma mansoni tyrosine kinase 0.0036 0.0539 0.0803
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.2437 0.3631
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0093 0.2437 0.3631
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0141 0.404 0.601
Loa Loa (eye worm) hypothetical protein 0.0086 0.2213 0.2203
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Brugia malayi neuropeptide F receptor 0.0093 0.2437 0.5153
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0093 0.2437 0.3631
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Loa Loa (eye worm) hypothetical protein 0.022 0.6713 0.6709
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.2953 0.6925
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.2981 0.871
Schistosoma mansoni biogenic amine (5HT) receptor 0.022 0.6713 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0145 0.4192 0.6236
Echinococcus granulosus alpha 1A adrenergic receptor 0.0093 0.2437 0.3618
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.1038 0.1162
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Echinococcus granulosus growth factor receptor bound protein 2 0.0032 0.0388 0.0559
Echinococcus granulosus serotonin receptor 0.0093 0.2437 0.3618
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Schistosoma mansoni growth factor receptor-bound protein 0.0032 0.0388 0.0578
Loa Loa (eye worm) inositol-1 0.0037 0.0566 0.0553
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0093 0.2437 0.2427
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0093 0.2437 0.3631
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2981 0.8155
Echinococcus granulosus tyrosine protein kinase Src42A 0.0141 0.404 0.601
Brugia malayi putative neuropeptide receptor NPR1 0.0093 0.2437 0.5153
Schistosoma mansoni adapter molecule crk 0.0032 0.0388 0.0578
Schistosoma mansoni biogenic amine receptor 0.0093 0.2437 0.3631
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.2981 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0566 0.0824
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0158 0.4627 0.6893
Loa Loa (eye worm) SRC-1 0.0161 0.4718 0.4711
Brugia malayi SRC-1 0.0161 0.4718 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0086 0.2213 0.3283
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Echinococcus multilocularis rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0063 0.1432 0.2133
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0161 0.4718 0.7021
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.1038 0.1162
Schistosoma mansoni neuropeptide receptor 0.0093 0.2437 0.3631
Echinococcus granulosus tm gpcr rhodopsin 0.0093 0.2437 0.3618
Schistosoma mansoni neuropeptide F-like receptor 0.0093 0.2437 0.3631
Schistosoma mansoni lipoxygenase 0.0055 0.1181 0.1759
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0914 0.1344
Echinococcus granulosus tyrosine protein kinase Lyn 0.0161 0.4733 0.7044
Loa Loa (eye worm) hypothetical protein 0.0093 0.2437 0.2427
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.2981 0.5947
Echinococcus multilocularis allatostatin A receptor 0.0093 0.2437 0.3618
Schistosoma mansoni opsin-like receptor 0.0093 0.2437 0.3631
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0093 0.2437 0.3618
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.3358 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.1038 0.1162
Echinococcus granulosus dro:myosuppressin receptor 0.0093 0.2437 0.3618
Schistosoma mansoni neuropeptide receptor 0.0093 0.2437 0.3631
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0063 0.1432 0.2742
Echinococcus granulosus rhodopsin orphan GPCR 0.0093 0.2437 0.3618
Echinococcus multilocularis tyrosine protein kinase Abl 0.0036 0.0539 0.0785
Onchocerca volvulus 0.0093 0.2437 0.5254
Echinococcus granulosus neuropeptide receptor A26 0.0093 0.2437 0.3618
Echinococcus granulosus tyrosine kinase 0.0145 0.4192 0.6236
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0566 0.1518
Echinococcus granulosus g protein coupled receptor 0.0093 0.2437 0.3618
Brugia malayi protein-tyrosine kinase 0.0145 0.4192 0.8882
Echinococcus granulosus g protein coupled receptor 0.0093 0.2437 0.3618
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.2437 0.2427
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.2953 0.6925
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.2981 0.8155
Brugia malayi hypothetical protein 0.0093 0.2437 0.5153
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.1038 0.1529
Trypanosoma brucei oligopeptidase b 0.0063 0.1432 0.2133
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0093 0.2437 0.3618
Echinococcus multilocularis g protein coupled receptor 0.0093 0.2437 0.3618
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0063 0.1432 0.2133
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0093 0.2437 0.3618
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0161 0.4718 0.7021
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0566 0.059
Loa Loa (eye worm) G-protein coupled receptor 0.0093 0.2437 0.2427
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0093 0.2437 0.3618
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0093 0.2437 0.3618
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0086 0.2213 0.2203
Echinococcus granulosus prolyl endopeptidase 0.0158 0.4627 0.6886
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0055 0.1181 0.1742
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0093 0.2437 0.3631
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.2981 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0063 0.1432 0.341
Echinococcus multilocularis somatostatin receptor 0.0093 0.2437 0.3618

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2020 nM In vitro inhibitory activity against prolyl endopeptidase (PEP) ChEMBL. 7932578
IC50 (binding) = 2020 nM In vitro inhibitory activity against prolyl endopeptidase (PEP) ChEMBL. 7932578

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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