Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.4569 | 0.2516 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4569 | 0.2516 | 0.2486 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.0063 | 0.0023 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.4569 | 0.2516 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.4569 | 0.2516 | 1 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0346 | 0.0139 | 0.046 |
Mycobacterium leprae | probable zinc metalloprotease | 0.4569 | 0.2516 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3456 | 0.189 | 0.1856 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.4569 | 0.2516 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0172 | 0.0041 | 0.0009 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.2305 | 0.1242 | 0.4935 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.1113 | 0.0571 | 0.0532 |
Loa Loa (eye worm) | hypothetical protein | 0.3456 | 0.189 | 0.1856 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0024 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.4569 | 0.2516 | 0.2486 |
Schistosoma mansoni | hypothetical protein | 0.1192 | 0.0615 | 0.2445 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.1113 | 0.0571 | 0.2267 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1113 | 0.0571 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.3456 | 0.189 | 0.1856 |
Schistosoma mansoni | hypothetical protein | 0.1192 | 0.0615 | 0.2445 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.3377 | 0.1845 | 0.1811 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.1113 | 0.0571 | 0.2267 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.4569 | 0.2516 | 0.2492 |
Loa Loa (eye worm) | hypothetical protein | 0.2264 | 0.1218 | 0.1182 |
Schistosoma mansoni | hypothetical protein | 0.1192 | 0.0615 | 0.2445 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 1.7861 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0144 | 0.0025 | 0.01 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0144 | 0.0025 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.3377 | 0.1845 | 0.1811 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.1113 | 0.0571 | 0.2267 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1113 | 0.0571 | 0.2267 |
Loa Loa (eye worm) | hypothetical protein | 0.3377 | 0.1845 | 0.1811 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.2305 | 0.1242 | 0.4935 |
Schistosoma mansoni | neprilysin | 0.1192 | 0.0615 | 0.2445 |
Loa Loa (eye worm) | hypothetical protein | 0.4569 | 0.2516 | 0.2486 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0212 | 0.0063 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.3377 | 0.1845 | 0.1811 |
Schistosoma mansoni | hypothetical protein | 0.1192 | 0.0615 | 0.2445 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1192 | 0.0615 | 0.2445 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.3377 | 0.1845 | 0.1811 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0346 | 0.0139 | 0.046 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.2305 | 0.1242 | 0.4935 |
Brugia malayi | Peptidase family M13 containing protein | 0.4569 | 0.2516 | 0.2492 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.2305 | 0.1242 | 0.4935 |
Brugia malayi | peptidase family M13 containing protein | 0.1113 | 0.0571 | 0.054 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0196 | 0.0054 | 0.0216 |
Loa Loa (eye worm) | hypothetical protein | 0.3456 | 0.189 | 0.1856 |
Loa Loa (eye worm) | hypothetical protein | 0.3377 | 0.1845 | 0.1811 |
Mycobacterium ulcerans | zinc metalloprotease | 0.4569 | 0.2516 | 0.5 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0346 | 0.0139 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.3456 | 0.189 | 0.1856 |
Onchocerca volvulus | 0.2264 | 0.1218 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.0105 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.3456 | 0.189 | 0.1856 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.2305 | 0.1242 | 0.4935 |
Toxoplasma gondii | peptidase family M13 protein | 0.4569 | 0.2516 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1192 | 0.0615 | 0.2445 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0212 | 0.0063 | 0.0158 |
Schistosoma mansoni | hypothetical protein | 0.1192 | 0.0615 | 0.2445 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1113 | 0.0571 | 0.2267 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0144 | 0.0025 | 0.0004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 30 nM | Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compound | ChEMBL. | 2542553 |
IC50 (functional) | = 30 nM | Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compound | ChEMBL. | 2542553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.