Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Voltage-gated L-type calcium channel alpha-1C subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.7215 | 0.7215 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0093 | 0.0349 | 0.0349 |
Echinococcus multilocularis | aminopeptidase N | 0.0254 | 0.3437 | 0.3437 |
Onchocerca volvulus | 0.0254 | 0.3437 | 0.8123 | |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0093 | 0.0349 | 0.0349 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0075 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.7215 | 0.7215 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0301 | 0.4335 | 0.4335 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0075 | 0 | 0.5 |
Schistosoma mansoni | neprilysin | 0.0156 | 0.155 | 0.155 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0093 | 0.0349 | 0.0349 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0075 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.4231 | 0.4231 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0093 | 0.0349 | 0.0349 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0596 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.155 | 0.155 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0156 | 0.155 | 0.155 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0145 | 0.1351 | 0.1351 |
Schistosoma mansoni | voltage-gated cation channel | 0.0093 | 0.0349 | 0.0349 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0075 | 0 | 0.5 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0301 | 0.4335 | 0.4335 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.155 | 0.155 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0441 | 0.7016 | 0.7016 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.7016 | 0.7016 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0093 | 0.0349 | 0.0349 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.7016 | 0.7016 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0145 | 0.1351 | 0.1351 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0145 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.7016 | 0.7016 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.7215 | 0.7215 |
Loa Loa (eye worm) | calcium channel | 0.0093 | 0.0349 | 0.0349 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0093 | 0.0349 | 0.0349 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0093 | 0.0349 | 0.0349 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0093 | 0.0349 | 0.0349 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.155 | 0.155 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0596 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0254 | 0.3437 | 0.3437 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0093 | 0.0349 | 0.0349 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0075 | 0 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0145 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.7215 | 0.7215 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0145 | 0.1351 | 0.1351 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0301 | 0.4335 | 0.4335 |
Toxoplasma gondii | peptidase family M13 protein | 0.0596 | 1 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0145 | 0.1351 | 0.1351 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0596 | 1 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0301 | 0.4335 | 0.4335 |
Loa Loa (eye worm) | hypothetical protein | 0.0441 | 0.7016 | 0.7016 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0075 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.0075 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0441 | 0.7016 | 0.7016 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.155 | 0.155 |
Loa Loa (eye worm) | zinc metallopeptidase 4 | 0.0145 | 0.1351 | 0.1351 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0075 | 0 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0093 | 0.0349 | 0.0349 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0075 | 0 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.0254 | 0.3437 | 0.3437 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.2933 | 0.2933 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0301 | 0.4335 | 0.4335 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0075 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.155 | 0.155 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.155 | 0.155 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0206 | 0.2507 | 0.2507 |
Loa Loa (eye worm) | hypothetical protein | 0.0179 | 0.2003 | 0.2003 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0093 | 0.0349 | 0.0349 |
Brugia malayi | peptidase family M13 containing protein | 0.0145 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.7215 | 0.7215 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0451 | 0.7215 | 0.7215 |
Onchocerca volvulus | 0.0295 | 0.4231 | 1 | |
Mycobacterium leprae | probable zinc metalloprotease | 0.0596 | 1 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0093 | 0.0349 | 0.0349 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0596 | 1 | 1 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0093 | 0.0349 | 0.0349 |
Loa Loa (eye worm) | hypothetical protein | 0.0596 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0075 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1 uM | Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determined | ChEMBL. | No reference |
IC50 (binding) | > 1 uM | Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determined | ChEMBL. | No reference |
pA2 (functional) | = 6.6 | Calcium channel-blocking effect was assessed in potassium ion depolarized guinea pig ileum strips by recording the contractile responses produced by varying concentrations of calcium chloride | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.