Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania braziliensis | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 608 aa | 26.0 % |
Dictyostelium discoideum | oligopeptidase B | Prolyl endopeptidase | 710 aa | 735 aa | 23.7 % |
Trypanosoma congolense | oligopeptidase b | Prolyl endopeptidase | 710 aa | 589 aa | 27.8 % |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | Prolyl endopeptidase | 710 aa | 714 aa | 26.5 % |
Leishmania major | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.9 % |
Leishmania donovani | oligopeptidase b | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Trypanosoma brucei gambiense | oligopeptidase B, putative | Prolyl endopeptidase | 710 aa | 629 aa | 26.4 % |
Leishmania infantum | oligopeptidase b;with=GeneDB:LmjF09.0770 | Prolyl endopeptidase | 710 aa | 743 aa | 24.4 % |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | Prolyl endopeptidase | 710 aa | 741 aa | 25.6 % |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Leishmania mexicana | oligopeptidase b,serine peptidase, clan SC, family S9A-like protein | Prolyl endopeptidase | 710 aa | 720 aa | 24.7 % |
Onchocerca volvulus | Prolyl endopeptidase | 710 aa | 722 aa | 47.6 % | |
Trypanosoma cruzi | oligopeptidase b | Prolyl endopeptidase | 710 aa | 719 aa | 25.6 % |
Trypanosoma brucei | oligopeptidase b | Prolyl endopeptidase | 710 aa | 630 aa | 26.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0309 | 0.0355 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0993 | 0.2714 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0309 | 0.0309 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.0309 | 0.0355 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0158 | 0.8719 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.8719 | 0.8719 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0993 | 0.1139 |
Brugia malayi | Heterochromatin protein 1 | 0.0073 | 0.3108 | 0.3564 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0073 | 0.3108 | 0.3564 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Brugia malayi | chromobox protein homolog 3 | 0.0041 | 0.0993 | 0.1139 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.0309 | 0.0355 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.1098 | 0.1098 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0309 | 0.0309 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0733 | 0.0733 |
Schistosoma mansoni | jumonji domain containing protein | 0.0079 | 0.3535 | 0.3535 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.8719 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.3108 | 1 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0733 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0309 | 0.0355 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.0309 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0993 | 0.2714 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.2453 | 0.2814 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1198 | 0.3419 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.0309 | 0.0309 |
Trypanosoma brucei | prolyl endopeptidase | 0.0158 | 0.8719 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0158 | 0.8719 | 1 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.3108 | 0.3108 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0063 | 0.2441 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.01 | 0.4891 | 0.4891 |
Onchocerca volvulus | 0.0032 | 0.041 | 0.0471 | |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0142 | 0.7626 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0158 | 0.8719 | 0.8719 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.0309 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0158 | 0.8719 | 1 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.0309 | 0.0309 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0158 | 0.8719 | 0.8719 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 1 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0733 | 0.0733 |
Echinococcus multilocularis | geminin | 0.0178 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0073 | 0.3108 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.1198 | 0.1374 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0063 | 0.2441 | 0.5 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.0309 | 0.0309 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.1098 | 0.1098 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.0309 | 0.0309 |
Trichomonas vaginalis | chromobox protein, putative | 0.0044 | 0.1198 | 0.3419 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0158 | 0.8719 | 0.8719 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0733 | 0.0733 |
Brugia malayi | jmjC domain containing protein | 0.01 | 0.4891 | 0.5609 |
Echinococcus multilocularis | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0158 | 0.8719 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0733 | 0.0841 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0993 | 0.1139 |
Echinococcus granulosus | chromobox protein 1 | 0.0073 | 0.3108 | 0.3108 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0309 | 0.5 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0733 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1748 | 0.2005 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0309 | 0.0355 |
Schistosoma mansoni | chromobox protein | 0.0073 | 0.3108 | 0.3108 |
Toxoplasma gondii | prolyl endopeptidase | 0.0158 | 0.8719 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.01 | 0.4891 | 0.4891 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.041 | 0.0471 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.