Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Cysteinyl leukotriene receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | cysteinyl leukotriene receptor 1 | References | |
Homo sapiens | cysteinyl leukotriene receptor 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | 0 mg kg-1 | Oral activity expressed as percent inhibition in LTD4-induced wheal assay in guinea pig; Not determined | ChEMBL. | 2157009 |
ED50 (functional) | = 145 mg kg-1 | Oral activity expressed as effective dose in leukotriene mediated anaphylaxis assay in guinea pig | ChEMBL. | 2157009 |
IC50 (functional) | = 200 nM | Inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips. | ChEMBL. | 2157009 |
IC50 (functional) | = 200 nM | Inhibition of the spasmogenic activity of LTD4 in guinea pig parenchymal strips. | ChEMBL. | 2157009 |
Inhibition (functional) | = 13 % | Inhibition of LTD4-induced broncho constriction in Guinea pig after intragastrical administration of a dose of 3 mg/kg | ChEMBL. | 2104935 |
Inhibition (functional) | < 89 % | Inhibition of LTD4-induced broncho constriction in Guinea pig after intragastrical administration of a dose of 25 mg/kg | ChEMBL. | 2104935 |
Inhibition (functional) | = 90 % | Tested for the inhibition of LTD4-induced broncho constriction in Guinea pig, injected intraduodenally at a dose of 25 mg/kg | ChEMBL. | 2104935 |
Ki (binding) | = 115 nM | Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM) | ChEMBL. | 2157009 |
Ki (binding) | = 115 nM | Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4 (0.2 nM) | ChEMBL. | 2157009 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.