Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.003 | 0.0257 | 0.2427 | |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0257 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Onchocerca volvulus | 0.003 | 0.0257 | 0.2427 | |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0061 | 0.1613 | 0.2002 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.1951 | 0.2709 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0035 | 0.0494 | 0.0243 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.3365 | 0.4233 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0172 | 0.6509 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0197 | 0.7599 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0061 | 0.1613 | 0.8346 |
Brugia malayi | RNA binding protein | 0.005 | 0.1134 | 0.1195 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0101 | 0.3365 | 0.4233 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.004 | 0.0679 | 0.0574 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.3365 | 0.4233 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0197 | 0.7599 | 1 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0068 | 0.1932 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0134 | 0.4814 | 0.6206 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.005 | 0.1134 | 0.1364 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.1385 | 0.1536 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0438 | 0.2265 |
Entamoeba histolytica | protein kinase, putative | 0.0134 | 0.4814 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.003 | 0.0257 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.3365 | 0.4971 |
Brugia malayi | RNA recognition motif domain containing protein | 0.005 | 0.1134 | 0.1195 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0172 | 0.6509 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.0438 | 0.2265 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.3365 | 0.4971 |
Schistosoma mansoni | lipoxygenase | 0.004 | 0.0679 | 0.0674 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0257 | 0.1332 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.004 | 0.0679 | 0.0574 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0035 | 0.0494 | 0.0243 |
Echinococcus granulosus | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 0.3365 | 0.4343 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.7599 | 1 |
Trichomonas vaginalis | esterase, putative | 0.003 | 0.0257 | 0.1332 |
Schistosoma mansoni | chromobox protein | 0.0061 | 0.1613 | 0.2168 |
Entamoeba histolytica | protein kinase, putative | 0.0134 | 0.4814 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.005 | 0.1134 | 0.1195 |
Echinococcus multilocularis | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.6509 | 0.8543 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.003 | 0.0257 | 0.0192 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.003 | 0.0257 | 0.1332 |
Trichomonas vaginalis | chromobox protein, putative | 0.0037 | 0.0551 | 0.2854 |
Schistosoma mansoni | chromobox protein | 0.0061 | 0.1613 | 0.2168 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0119 | 0.4174 | 0.402 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0252 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.4174 | 0.402 |
Loa Loa (eye worm) | IRE protein kinase | 0.0134 | 0.4814 | 0.6278 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0172 | 0.6509 | 0.8514 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.1385 | 0.1698 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0043 | 0.0834 | 0.0592 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0192 | 0.7363 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0037 | 0.0551 | 0.2854 |
Echinococcus granulosus | chromobox protein 1 | 0.0061 | 0.1613 | 0.1846 |
Loa Loa (eye worm) | beta-lactamase | 0.003 | 0.0257 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0705 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0134 | 0.4814 | 0.6206 |
Loa Loa (eye worm) | RNA binding protein | 0.005 | 0.1134 | 0.1364 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0119 | 0.4174 | 0.402 |
Echinococcus multilocularis | tar DNA binding protein | 0.005 | 0.1134 | 0.1195 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0134 | 0.4814 | 0.6206 |
Onchocerca volvulus | 0.003 | 0.0257 | 0.2427 | |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0037 | 0.0551 | 0.7401 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0133 | 0.4765 | 0.6343 |
Mycobacterium leprae | conserved hypothetical protein | 0.003 | 0.0257 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.3365 | 0.4233 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0438 | 0.0433 |
Schistosoma mansoni | survival motor neuron protein | 0.004 | 0.0705 | 0.0716 |
Echinococcus granulosus | hormone sensitive lipase | 0.0172 | 0.6509 | 0.8514 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0035 | 0.0494 | 0.0243 |
Onchocerca volvulus | 0.004 | 0.0705 | 1 | |
Brugia malayi | chromobox protein homolog 3 | 0.0034 | 0.0438 | 0.0246 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0257 | 0.0192 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0252 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.005 | 0.1134 | 0.1195 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0257 | 0.1332 |
Brugia malayi | hypothetical protein | 0.0197 | 0.7599 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Schistosoma mansoni | tar DNA-binding protein | 0.005 | 0.1134 | 0.1403 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0034 | 0.0438 | 0.5476 |
Trichomonas vaginalis | chromobox protein, putative | 0.0061 | 0.1613 | 0.8346 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.003 | 0.0257 | 0.1332 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0035 | 0.0494 | 0.0243 |
Mycobacterium ulcerans | hypothetical protein | 0.0133 | 0.4765 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.003 | 0.0257 | 0.1332 |
Toxoplasma gondii | hypothetical protein | 0.0041 | 0.0723 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.005 | 0.1134 | 0.1364 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.3365 | 0.4233 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0068 | 0.1932 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.3365 | 0.4971 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0172 | 0.6509 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.004 | 0.0705 | 0.061 |
Brugia malayi | Heterochromatin protein 1 | 0.0061 | 0.1613 | 0.1846 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.