Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0403 | 0.5026 | 1 |
Trypanosoma brucei | thymidine kinase | 0.0754 | 1 | 1 |
Brugia malayi | WGR domain containing protein | 0.0095 | 0.0677 | 0.1347 |
Loa Loa (eye worm) | thymidylate synthase | 0.0403 | 0.5026 | 1 |
Echinococcus granulosus | WGR domain containing protein | 0.0054 | 0.0091 | 0.0181 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.045 | 0.5698 | 1 |
Leishmania major | thymidine kinase, putative | 0.0754 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.0677 | 0.1347 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0192 | 0.2039 | 0.146 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0754 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0082 | 0.0495 | 0.0985 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0754 | 1 | 1 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.1784 | 0.355 |
Giardia lamblia | Thymidine kinase | 0.0754 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1198 | 0.2383 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.0677 | 0.1347 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0754 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0403 | 0.5026 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.045 | 0.5698 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.045 | 0.5698 | 0.5386 |
Echinococcus granulosus | thymidylate synthase | 0.0403 | 0.5026 | 1 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0054 | 0.0091 | 0.0181 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.045 | 0.5698 | 0.5386 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0754 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0403 | 0.5026 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.045 | 0.5698 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0403 | 0.5026 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0754 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0047 | 0 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.1784 | 0.355 |
Brugia malayi | hypothetical protein | 0.0192 | 0.2039 | 0.4056 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.1784 | 0.355 |
Onchocerca volvulus | 0.0403 | 0.5026 | 0.5 | |
Mycobacterium tuberculosis | Hypothetical protein | 0.0192 | 0.2039 | 0.4056 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0403 | 0.5026 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0403 | 0.5026 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.1784 | 0.355 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.0677 | 0.1347 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0677 | 0.1347 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.0068 | 0.0296 | 0.0588 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Drug metabolism (ADMET) | Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation in presence NADH at 10 uM after 60 mins by LC-MS/MS method | ChEMBL. | 20947616 | |
Drug metabolism (ADMET) | Drug metabolism assessed as human recombinant FMO1-mediated ER-879123 formation at 10 uM after 60 mins by LC-MS/MS method in presence of NADPH | ChEMBL. | 20947616 | |
Drug metabolism (ADMET) | Drug metabolism assessed as human recombinant FMO1-mediated ER-879123 formation in presence NADH at 10 uM after 60 mins by LC-MS/MS method | ChEMBL. | 20947616 | |
Drug metabolism (ADMET) | Drug metabolism assessed as human recombinant FMO3-mediated ER-879123 formation at 10 uM after 60 mins by LC-MS/MS method in presence of NADPH | ChEMBL. | 20947616 | |
Drug metabolism (ADMET) | Drug metabolism assessed as human recombinant FMO3-mediated ER-879123 formation in presence NADH at 10 uM after 60 mins by LC-MS/MS method | ChEMBL. | 20947616 | |
Drug metabolism (ADMET) | Drug metabolism assessed as human recombinant FMO5-mediated ER-879123 formation at 10 uM after 60 mins by LC-MS/MS method in presence of NADPH | ChEMBL. | 20947616 | |
IC50 (binding) | = 120 nM | BindingDB_Patents: PARP Enzyme Assay. PARP assay using purified recombinant human PARP from Trevigan. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.