Detailed information for compound 2073909

Basic information

Technical information
  • TDR Targets ID: 2073909
  • Name: 7-methoxy-2-(piperidin-1-ylmethyl)-3,4-dihydr o-2H-naphthalen-1-one
  • MW: 273.37 | Formula: C17H23NO2
  • H donors: 0 H acceptors: 1 LogP: 2.91 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)C(=O)C(CC2)CN1CCCCC1
  • InChi: 1S/C17H23NO2/c1-20-15-8-7-13-5-6-14(17(19)16(13)11-15)12-18-9-3-2-4-10-18/h7-8,11,14H,2-6,9-10,12H2,1H3
  • InChiKey: WOQNPZDMMKKFPR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-methoxy-2-(1-piperidylmethyl)tetralin-1-one
  • 7-methoxy-2-(1-piperidylmethyl)-1-tetralinone
  • 7-methoxy-2-(piperidinomethyl)tetralin-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0118
Toxoplasma gondii kinase, pfkB family protein 0.0022 0.0118 0.018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0043 0.0898 1
Echinococcus multilocularis adenosine kinase 0.0195 0.649 0.9498
Leishmania major putative PfkB family sugar kinase 0.0022 0.0118 0.018
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0419 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0118 0.5
Trypanosoma cruzi adenosine kinase, putative 0.0195 0.649 1
Entamoeba histolytica hypothetical protein 0.0043 0.0898 1
Echinococcus multilocularis pseudouridine metabolizing bifunctional protein 0.0022 0.0118 0.0173
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0001 0.0002
Schistosoma mansoni adenosine kinase 0.0195 0.649 0.9498
Trichomonas vaginalis ribokinase, putative 0.0022 0.0118 0.5
Schistosoma mansoni hypothetical protein 0.0043 0.0898 0.1315
Brugia malayi hypothetical protein 0.002 0.0022 0.0022
Echinococcus granulosus geminin 0.0205 0.6833 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.006 0.1515 0.1515
Echinococcus granulosus ribokinase 0.0022 0.0118 0.0173
Trypanosoma cruzi ribokinase, putative 0.0022 0.0118 0.018
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0419 0.0645
Trypanosoma brucei adenosine kinase, putative 0.0195 0.649 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0419 0.0645
Brugia malayi hypothetical protein 0.0043 0.0898 0.0898
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0419 0.0645
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0001 0.0002
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0001 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0001 0.0002
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0898 0.1315
Mycobacterium leprae Probable adenosine kinase adk 0.0022 0.0118 0.5
Loa Loa (eye worm) hypothetical protein 0.003 0.0419 0.0419
Echinococcus multilocularis geminin 0.0205 0.6833 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 1 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.649 0.649
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0898 0.1315
Trichomonas vaginalis ribokinase, putative 0.0022 0.0118 0.5
Schistosoma mansoni hypothetical protein 0.0041 0.0814 0.1191
Entamoeba histolytica hypothetical protein 0.0043 0.0898 1
Leishmania major adenosine kinase-like protein 0.0022 0.0118 0.018
Leishmania major ribokinase, putative 0.0022 0.0118 0.018
Brugia malayi hypothetical protein 0.003 0.0419 0.0419
Brugia malayi Ribokinase 0.0022 0.0118 0.0118
Trypanosoma cruzi adenosine kinase, putative 0.0195 0.649 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0898 0.1315
Echinococcus multilocularis ribokinase 0.0022 0.0118 0.0173
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0118 0.0118
Trypanosoma brucei ribokinase, putative 0.0022 0.0118 0.018
Trypanosoma brucei adenosine kinase, putative 0.0195 0.649 1
Echinococcus granulosus pseudouridine metabolizing bifunctional protein 0.0022 0.0118 0.0173
Leishmania major tagatose-6-phosphate kinase-like protein 0.0022 0.0118 0.018
Trichomonas vaginalis ribokinase, putative 0.0022 0.0118 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.4607 0.4607
Brugia malayi isocitrate dehydrogenase 0.0019 0.0001 0.0001
Trypanosoma cruzi adenosine kinase, putative 0.0022 0.0118 0.018
Loa Loa (eye worm) hypothetical protein 0.0041 0.0814 0.0814
Mycobacterium ulcerans fructokinase, PfkB 0.0022 0.0118 0.5
Mycobacterium ulcerans carbohydrate kinase CbhK 0.0022 0.0118 0.5
Schistosoma mansoni hypothetical protein 0.0205 0.6833 1
Mycobacterium tuberculosis 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) 0.0022 0.0118 1
Onchocerca volvulus 0.0291 1 1
Mycobacterium tuberculosis Adenosine kinase 0.0022 0.0118 1
Schistosoma mansoni adenosine kinase 0.0195 0.649 0.9498
Brugia malayi hypothetical protein 0.0022 0.0118 0.0118
Schistosoma mansoni ribokinase 0.0022 0.0118 0.0173
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0419 1
Brugia malayi Adenosine kinase-like 0.0195 0.649 0.649
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0001 0.0002
Entamoeba histolytica hypothetical protein 0.0043 0.0898 1
Giardia lamblia Ribokinase 0.0022 0.0118 0.5
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.4607 0.4607
Brugia malayi MH2 domain containing protein 0.0144 0.4607 0.4607
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0001 0.0002
Mycobacterium tuberculosis Ribokinase RbsK 0.0022 0.0118 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1515 0.1515
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0419 1
Trypanosoma cruzi adenosine kinase, putative 0.0022 0.0118 0.018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0001 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0419 0.0645
Toxoplasma gondii kinase, pfkB family protein 0.0195 0.649 1
Leishmania major tagatose-6-phosphate kinase-like protein 0.0022 0.0118 0.018
Leishmania major adenosine kinase, putative 0.0195 0.649 1
Leishmania major hypothetical protein, conserved 0.003 0.0419 0.0645
Trypanosoma brucei ribokinase, putative 0.0022 0.0118 0.018
Leishmania major adenosine kinase-like protein 0.0022 0.0118 0.018
Onchocerca volvulus 0.0173 0.567 0.5619
Echinococcus granulosus adenosine kinase 0.0195 0.649 0.9498
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1515 0.1515
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1515 0.1515
Schistosoma mansoni hypothetical protein 0.0205 0.6833 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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