Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAZ zinc finger family protein | 0.0293 | 0.3268 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0077 | 0.056 | 0.5 |
Schistosoma mansoni | N-myristoyltransferase | 0.0167 | 0.1693 | 0.4824 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0167 | 0.1693 | 1 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0293 | 0.3268 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0167 | 0.1693 | 0.4876 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0147 | 0.1448 | 0.4017 |
Loa Loa (eye worm) | hypothetical protein | 0.0209 | 0.2212 | 1 |
Echinococcus granulosus | CREB binding protein | 0.0182 | 0.1883 | 0.5493 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0163 | 0.1648 | 0.4727 |
Mycobacterium tuberculosis | Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) | 0.0831 | 1 | 0.5 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0167 | 0.1693 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0167 | 0.1693 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0209 | 0.2212 | 1 |
Onchocerca volvulus | 0.005 | 0.0225 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1299 | 0.5403 |
Mycobacterium ulcerans | naphthoate synthase | 0.0831 | 1 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0147 | 0.1448 | 0.6209 |
Loa Loa (eye worm) | CBP-B | 0.0205 | 0.2164 | 0.9756 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0167 | 0.1693 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.005 | 0.0225 | 0.0152 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0147 | 0.1448 | 0.4076 |
Brugia malayi | Choline O-acetyltransferase | 0.0209 | 0.2212 | 0.653 |
Schistosoma mansoni | choline o-acyltransferase | 0.0209 | 0.2212 | 0.653 |
Giardia lamblia | CDC72 | 0.0167 | 0.1693 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0077 | 0.056 | 0.5 |
Brugia malayi | N-myristoyltransferase 2 | 0.0167 | 0.1693 | 0.4824 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0147 | 0.1448 | 0.8326 |
Leishmania major | N-myristoyl transferase, putative | 0.0167 | 0.1693 | 1 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0077 | 0.056 | 0.3307 |
Trypanosoma brucei | N-myristoyltransferase | 0.0167 | 0.1693 | 1 |
Onchocerca volvulus | 0.005 | 0.0225 | 0.5 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0195 | 0.2046 | 0.5983 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0167 | 0.1693 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0202 | 0.2133 | 0.9604 |
Onchocerca volvulus | 0.005 | 0.0225 | 0.5 | |
Loa Loa (eye worm) | acetyltransferase | 0.0195 | 0.2046 | 0.9162 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0167 | 0.1693 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0077 | 0.056 | 0.1189 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1448 | 0.6151 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0293 | 0.3268 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0195 | 0.2046 | 0.5983 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0147 | 0.1448 | 0.8326 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0167 | 0.1693 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0167 | 0.1693 | 0.7387 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0077 | 0.056 | 0.3307 |
Brugia malayi | Choline O-acetyltransferase | 0.0209 | 0.2212 | 0.653 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0147 | 0.1448 | 0.8326 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0195 | 0.2046 | 0.9175 |
Onchocerca volvulus | 0.005 | 0.0225 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0209 | 0.2212 | 0.6565 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.011 | 0.0976 | 0.5764 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.005 | 0.0225 | 0.01 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0209 | 0.2212 | 1 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0167 | 0.1693 | 0.7427 |
Echinococcus granulosus | CREB binding protein | 0.0293 | 0.3268 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.