TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 265.393 | Formula: C19H23N
H donors: 0 H acceptors: 0 LogP: 4.5 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN([C@@H]1Cc2ccccc2[C@H](C1)c1ccccc1C)C
InChi: 1S/C19H23N/c1-14-8-4-6-10-17(14)19-13-16(20(2)3)12-15-9-5-7-11-18(15)19/h4-11,16,19H,12-13H2,1-3H3/t16-,19-/m1/s1
InChiKey: PPQJESFHSZPEOS-VQIMIIECSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0072	0.4877	1
Plasmodium vivax	SET domain protein, putative	0.0017	0.0593	0.0552
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0019	0.0756	0.0796
Plasmodium vivax	ataxin-2 like protein, putative	0.0015	0.0419	0.0168
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0072	0.4877	0.6878
Echinococcus granulosus	subfamily M14A unassigned peptidase	0.0029	0.1532	0.1804
Onchocerca volvulus	Subfamily M14A unassigned peptidase homolog	0.0029	0.1532	0.1231
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.0014	0.0343	0.0142
Echinococcus multilocularis	aminopeptidase N	0.0019	0.0756	0.0796
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0017	0.0593	0.0553
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0593	0.0553
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0017	0.0543	0.0304
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0796
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0796
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.1081	0.128
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0025	0.1184	0.1433
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0019	0.0756	0.0757
Loa Loa (eye worm)	MH2 domain-containing protein	0.0071	0.4835	0.5446
Plasmodium vivax	RNA helicase-1, putative	0.0072	0.4877	1
Brugia malayi	eukaryotic initiation factor 4A	0.0072	0.4877	0.561
Chlamydia trachomatis	DNA topoisomerase I	0.0014	0.0343	0.5
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0072	0.4877	0.6934
Brugia malayi	Pre-SET motif family protein	0.0017	0.0593	0.0682
Trypanosoma brucei	Aminopeptidase M1, putative	0.0019	0.0756	0.0757
Echinococcus multilocularis	G protein coupled receptor 139	0.0023	0.1081	0.128
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0017	0.0593	0.0553
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0593	0.0553
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.1184	0.1433
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0072	0.4877	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0025	0.1184	0.1276
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0593	0.0553
Brugia malayi	MH2 domain containing protein	0.0071	0.4835	0.5562
Brugia malayi	Pre-SET motif family protein	0.012	0.8694	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0796
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0072	0.4877	0.4695
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0593	0.0553
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0072	0.4877	0.6934
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0019	0.0756	0.0428
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0796
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0025	0.1184	0.1362
Onchocerca volvulus		0.0029	0.1532	0.1231
Brugia malayi	hypothetical protein	0.0019	0.0756	0.087
Leishmania major	eukaryotic initiation factor 4a, putative	0.0072	0.4877	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.0019	0.0756	0.5
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0072	0.4877	0.6934
Echinococcus multilocularis	subfamily M14A unassigned peptidase	0.0029	0.1532	0.1951
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0627
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.0014	0.0343	0.018
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0627
Schistosoma mansoni	hypothetical protein	0.0098	0.6936	1
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0072	0.4877	0.5
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0017	0.0593	0.0552
Schistosoma mansoni	hypothetical protein	0.0014	0.0343	0.018
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0593	0.0438
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0019	0.0756	0.0757
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0072	0.4877	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0019	0.0756	0.0428
Echinococcus granulosus	aminopeptidase N	0.0019	0.0756	0.0627
Toxoplasma gondii	LsmAD domain-containing protein	0.0015	0.0419	0.0168
Onchocerca volvulus		0.0029	0.1532	0.1231
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0072	0.4877	0.5
Brugia malayi	brahma associated protein 60 kDa	0.0014	0.0343	0.0394
Brugia malayi	Peptidase family M1 containing protein	0.0019	0.0756	0.087
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0419	0.0232
Echinococcus multilocularis	SWI:SNF matrix associated	0.0014	0.0343	0.018
Onchocerca volvulus		0.0029	0.1532	0.1231
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0072	0.4877	0.6934
Plasmodium falciparum	ataxin-2 like protein, putative	0.0015	0.0419	0.0168
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0072	0.4877	1
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0072	0.4877	0.6878
Trypanosoma cruzi	PAB1-binding protein , putative	0.0015	0.0419	0.0423
Treponema pallidum	ATP-dependent RNA helicase	0.0072	0.4877	0.5
Schistosoma mansoni	hypothetical protein	0.0014	0.0343	0.018
Brugia malayi	hypothetical protein	0.0015	0.0419	0.0482
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0025	0.1184	0.1276
Loa Loa (eye worm)	aminopeptidase N	0.0019	0.0756	0.0631
Chlamydia trachomatis	SWIB complex protein	0.0014	0.0343	0.5
Loa Loa (eye worm)	hypothetical protein	0.0072	0.4877	0.5495
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0593	0.038
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0072	0.4877	0.4695
Schistosoma mansoni	hypothetical protein	0.0014	0.0343	0.018
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0019	0.0756	0.0796
Schistosoma mansoni	neuropeptide receptor	0.0023	0.1081	0.128
Onchocerca volvulus		0.0019	0.0756	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0024	0.1138	0.1081
Schistosoma mansoni	brg-1 associated factor	0.0014	0.0343	0.018
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0072	0.4877	1
Brugia malayi	brahma associated protein 60 kDa	0.0014	0.0343	0.0394
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0796
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0019	0.0756	0.0757
Leishmania major	eukaryotic initiation factor 4a, putative	0.0072	0.4877	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0627
Echinococcus multilocularis	geminin	0.0098	0.6936	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0019	0.0756	0.0627
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0025	0.1184	0.1135
Plasmodium falciparum	ataxin-2 like protein, putative	0.0015	0.0419	0.0168
Loa Loa (eye worm)	brahma associated protein	0.0014	0.0343	0.0142
Loa Loa (eye worm)	transcription factor SMAD2	0.0071	0.4835	0.5446
Onchocerca volvulus		0.0017	0.0593	0.0259
Brugia malayi	SWIB/MDM2 domain containing protein	0.0014	0.0343	0.0394
Echinococcus multilocularis	SWI:SNF matrix associated	0.0014	0.0343	0.018
Schistosoma mansoni	subfamily M14A unassigned peptidase (M14 family)	0.0029	0.1532	0.1951
Schistosoma mansoni	hypothetical protein	0.0098	0.6936	1
Brugia malayi	Peptidase family M1 containing protein	0.0019	0.0756	0.087
Trypanosoma cruzi	PAB1-binding protein , putative	0.0015	0.0419	0.0423
Trypanosoma cruzi	aminopeptidase, putative	0.0019	0.0756	0.1148
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.012	0.8694	1
Echinococcus granulosus	geminin	0.0098	0.6936	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.0019	0.0756	0.0757
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0072	0.4877	0.4695
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.1184	0.1433
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0025	0.1184	0.1433
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0072	0.4877	0.4695
Echinococcus multilocularis	SWI:SNF matrix associated	0.0014	0.0343	0.018
Echinococcus granulosus	neuropeptide receptor	0.0023	0.1081	0.112
Onchocerca volvulus		0.0029	0.1532	0.1231
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0072	0.4877	1
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0019	0.0756	0.1148
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0019	0.0756	0.1148
Trichomonas vaginalis	set domain proteins, putative	0.0137	1	1
Onchocerca volvulus		0.0019	0.0756	0.0428
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0025	0.1184	0.1433
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0019	0.0756	0.0796

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3547018

Bibliographic References

No literature references available for this target.

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Detailed information for compound 2074400