Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0017 | 0.0593 | 0.0553 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.1138 | 0.1081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0025 | 0.1184 | 0.1433 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0072 | 0.4877 | 0.6934 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0017 | 0.0543 | 0.0304 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.4877 | 1 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0017 | 0.0593 | 0.038 |
Echinococcus multilocularis | geminin | 0.0098 | 0.6936 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Schistosoma mansoni | neuropeptide receptor | 0.0023 | 0.1081 | 0.128 |
Echinococcus multilocularis | Upstream activation factor subunit UAF30 | 0.0014 | 0.0343 | 0.018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0025 | 0.1184 | 0.1433 |
Brugia malayi | MH2 domain containing protein | 0.0071 | 0.4835 | 0.5562 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0019 | 0.0756 | 0.0757 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0015 | 0.0419 | 0.0168 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0025 | 0.1184 | 0.1362 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0019 | 0.0756 | 0.0757 |
Brugia malayi | Peptidase family M1 containing protein | 0.0019 | 0.0756 | 0.087 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0017 | 0.0593 | 0.0552 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 0.6878 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0029 | 0.1532 | 0.1231 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0015 | 0.0419 | 0.0168 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.4877 | 0.5495 |
Onchocerca volvulus | 0.0017 | 0.0593 | 0.0259 | |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0072 | 0.4877 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0072 | 0.4877 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0015 | 0.0419 | 0.0423 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0029 | 0.1532 | 0.1951 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.6936 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0025 | 0.1184 | 0.1276 |
Brugia malayi | Pre-SET motif family protein | 0.0017 | 0.0593 | 0.0682 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Brugia malayi | Peptidase family M1 containing protein | 0.0019 | 0.0756 | 0.087 |
Brugia malayi | Pre-SET motif family protein | 0.012 | 0.8694 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0072 | 0.4877 | 1 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0593 | 0.0553 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0025 | 0.1184 | 0.1433 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0019 | 0.0756 | 0.1148 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0015 | 0.0419 | 0.0168 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0019 | 0.0756 | 0.0796 |
Onchocerca volvulus | 0.0019 | 0.0756 | 0.0428 | |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.4877 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0019 | 0.0756 | 0.0757 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0014 | 0.0343 | 0.018 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0756 | 0.087 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0023 | 0.1081 | 0.128 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0072 | 0.4877 | 0.6934 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.012 | 0.8694 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.6936 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0072 | 0.4877 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0015 | 0.0419 | 0.0423 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 1 |
Schistosoma mansoni | brg-1 associated factor | 0.0014 | 0.0343 | 0.018 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0343 | 0.018 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0025 | 0.1184 | 0.1433 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0072 | 0.4877 | 0.6878 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0419 | 0.0482 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 0.561 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0593 | 0.0553 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0072 | 0.4877 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0072 | 0.4877 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0017 | 0.0593 | 0.0553 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0019 | 0.0756 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0071 | 0.4835 | 0.5446 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0019 | 0.0756 | 0.0796 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0014 | 0.0343 | 0.5 |
Loa Loa (eye worm) | SWIB/MDM2 domain-containing protein | 0.0014 | 0.0343 | 0.0142 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0071 | 0.4835 | 0.5446 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0419 | 0.0232 |
Echinococcus granulosus | aminopeptidase N | 0.0019 | 0.0756 | 0.0627 |
Plasmodium vivax | SET domain protein, putative | 0.0017 | 0.0593 | 0.0552 |
Brugia malayi | brahma associated protein 60 kDa | 0.0014 | 0.0343 | 0.0394 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0017 | 0.0593 | 0.0553 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.4877 | 0.4695 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0072 | 0.4877 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0343 | 0.018 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Schistosoma mansoni | hypothetical protein | 0.0014 | 0.0343 | 0.018 |
Brugia malayi | brahma associated protein 60 kDa | 0.0014 | 0.0343 | 0.0394 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0017 | 0.0593 | 0.0553 |
Echinococcus multilocularis | neuropeptide receptor | 0.0023 | 0.1081 | 0.128 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0019 | 0.0756 | 0.1148 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0025 | 0.1184 | 0.1135 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0019 | 0.0756 | 0.1148 |
Echinococcus multilocularis | aminopeptidase N | 0.0019 | 0.0756 | 0.0796 |
Plasmodium vivax | RNA helicase-1, putative | 0.0072 | 0.4877 | 1 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0072 | 0.4877 | 0.4695 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0025 | 0.1184 | 0.1433 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0015 | 0.0419 | 0.0168 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0025 | 0.1184 | 0.1276 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.4877 | 0.4695 |
Brugia malayi | SWIB/MDM2 domain containing protein | 0.0014 | 0.0343 | 0.0394 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0014 | 0.0343 | 0.018 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0019 | 0.0756 | 0.0757 |
Echinococcus granulosus | neuropeptide receptor | 0.0023 | 0.1081 | 0.112 |
Loa Loa (eye worm) | aminopeptidase N | 0.0019 | 0.0756 | 0.0631 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0019 | 0.0756 | 0.0757 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0072 | 0.4877 | 0.6934 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0072 | 0.4877 | 0.4695 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0072 | 0.4877 | 0.5 |
Onchocerca volvulus | 0.0029 | 0.1532 | 0.1231 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0796 |
Chlamydia trachomatis | SWIB complex protein | 0.0014 | 0.0343 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0137 | 1 | 1 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0029 | 0.1532 | 0.1804 |
Loa Loa (eye worm) | brahma associated protein | 0.0014 | 0.0343 | 0.0142 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0019 | 0.0756 | 0.0627 |
Echinococcus granulosus | geminin | 0.0098 | 0.6936 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0019 | 0.0756 | 0.0796 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0019 | 0.0756 | 0.0428 |
Onchocerca volvulus | 0.0019 | 0.0756 | 0.0428 | |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0029 | 0.1532 | 0.1951 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0593 | 0.0438 |
Echinococcus multilocularis | SWI:SNF matrix associated | 0.0014 | 0.0343 | 0.018 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0072 | 0.4877 | 0.6934 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0019 | 0.0756 | 0.0428 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.