Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0732 | 0.0702 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0043 | 0.059 | 0.0568 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0122 | 0.0091 |
Brugia malayi | Fli-1 protein | 0.024 | 0.4131 | 0.4172 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0122 | 0.0091 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0015 | 0.0091 | 0.006 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0466 | 0.0442 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0122 | 0.0092 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0122 | 0.0091 |
Echinococcus multilocularis | jun protein | 0.0178 | 0.3023 | 0.3001 |
Schistosoma mansoni | gabp alpha | 0.0079 | 0.1244 | 0.1216 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.053 | 0.05 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0762 | 0.0744 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.0039 | 0.0521 | 0.8636 |
Brugia malayi | hypothetical protein | 0.0039 | 0.053 | 0.0508 |
Schistosoma mansoni | ap endonuclease | 0.0043 | 0.059 | 0.056 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0122 | 0.0092 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.053 | 0.05 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0685 | 0.0656 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0466 | 0.0442 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0762 | 0.0744 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0685 | 0.0665 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0079 | 0.1244 | 0.1216 |
Brugia malayi | hypothetical protein | 0.014 | 0.2337 | 0.2346 |
Onchocerca volvulus | 0.014 | 0.2337 | 1 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.053 | 0.05 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0685 | 0.0656 |
Schistosoma mansoni | ap endonuclease | 0.0043 | 0.059 | 0.056 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.0039 | 0.0521 | 0.8636 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0122 | 0.0091 |
Echinococcus multilocularis | geminin | 0.0567 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0685 | 0.0656 |
Toxoplasma gondii | exonuclease III APE | 0.0043 | 0.059 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0043 | 0.059 | 1 |
Schistosoma mansoni | jun-related protein | 0.0145 | 0.2424 | 0.24 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0043 | 0.059 | 0.5 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0079 | 0.1244 | 0.1216 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.0039 | 0.0521 | 0.0492 |
Schistosoma mansoni | ets-related | 0.024 | 0.4131 | 0.4112 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0015 | 0.0091 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0043 | 0.059 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0043 | 0.059 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0685 | 0.0656 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0122 | 0.0091 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0043 | 0.059 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0043 | 0.059 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0043 | 0.059 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0178 | 0.3023 | 0.3001 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0024 | 0.0256 | 0.3323 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0247 | 0.4267 | 0.4249 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0043 | 0.059 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.053 | 0.05 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0043 | 0.059 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.0013 | 0.0066 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0762 | 0.0744 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0466 | 0.0436 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0043 | 0.059 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0122 | 0.0091 |
Brugia malayi | Ets-domain containing protein | 0.0079 | 0.1244 | 0.1234 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0015 | 0.0091 | 0.006 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0247 | 0.4267 | 0.4249 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0178 | 0.3023 | 0.3001 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0043 | 0.059 | 0.056 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0015 | 0.0091 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0122 | 0.0091 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0015 | 0.0091 | 0.154 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0037 | 0.0497 | 0.0474 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.2936 | 0.2955 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0079 | 0.1244 | 0.1234 |
Loa Loa (eye worm) | fli-1 protein | 0.024 | 0.4131 | 0.4172 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0043 | 0.059 | 0.5 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0037 | 0.0497 | 0.0474 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0685 | 0.0656 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0122 | 0.0091 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.0039 | 0.0521 | 0.0492 |
Schistosoma mansoni | hypothetical protein | 0.0145 | 0.2424 | 0.24 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.0039 | 0.0521 | 0.0492 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0685 | 0.0665 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0015 | 0.0091 | 0.154 |
Schistosoma mansoni | hypothetical protein | 0.0567 | 1 | 1 |
Brugia malayi | Ets-domain containing protein | 0.0079 | 0.1244 | 0.1234 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0732 | 0.0713 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0122 | 0.0092 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0762 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0122 | 0.0092 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0043 | 0.059 | 1 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.0039 | 0.0521 | 0.8636 |
Schistosoma mansoni | pyruvate carboxylase | 0.0015 | 0.0091 | 0.006 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0685 | 0.0656 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0043 | 0.059 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0122 | 0.0091 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0122 | 0.0091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0685 | 0.0656 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0732 | 0.0702 |
Loa Loa (eye worm) | hypothetical protein | 0.0559 | 0.9858 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1038 | 0.1024 |
Brugia malayi | bZIP transcription factor family protein | 0.0178 | 0.3023 | 0.3045 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0043 | 0.059 | 0.056 |
Echinococcus granulosus | jun protein | 0.0178 | 0.3023 | 0.3001 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0015 | 0.0091 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.4267 | 0.4311 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.0039 | 0.0521 | 0.8846 |
Brugia malayi | small heat shock protein | 0.0559 | 0.9858 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0043 | 0.059 | 1 |
Brugia malayi | hypothetical protein | 0.0247 | 0.4267 | 0.4311 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0043 | 0.059 | 0.0568 |
Schistosoma mansoni | hypothetical protein | 0.0567 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.