Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0564 | 0.4637 | 1 |
Onchocerca volvulus | 0.0058 | 0.0387 | 1 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0088 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0495 | 0.4057 | 0.4057 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.2296 | 0.2296 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0088 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.2296 | 0.2296 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1203 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0088 | 0.5 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.0273 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0273 | 0.0273 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0045 | 0.0273 | 0.0273 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0387 | 0.0387 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0088 | 0.0088 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.0273 | 0.0273 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1203 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1203 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0564 | 0.4637 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.2296 | 0.2296 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1203 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.0273 | 0.0405 |
Schistosoma mansoni | patched 1 | 0.0495 | 0.4057 | 0.4057 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0045 | 0.0273 | 0.0273 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0045 | 0.0273 | 0.0273 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0495 | 0.4057 | 0.4057 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0045 | 0.0273 | 0.0186 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0088 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0495 | 0.4057 | 0.4057 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0045 | 0.0273 | 0.0273 |
Echinococcus multilocularis | protein dispatched 1 | 0.0495 | 0.4057 | 0.4057 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0045 | 0.0273 | 0.0273 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0088 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1203 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0088 | 0.0088 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0088 | 0.0088 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1203 | 1 | 1 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.0273 | 0.0273 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0387 | 0.0387 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0045 | 0.0273 | 0.0405 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0088 | 0.0088 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0045 | 0.0273 | 0.0273 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0564 | 0.4637 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.2296 | 0.2296 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.0273 | 0.0186 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1203 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0045 | 0.0273 | 0.0405 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0045 | 0.0273 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0495 | 0.4057 | 0.8724 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0045 | 0.0273 | 0.0186 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0088 | 0.0088 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0045 | 0.0273 | 0.0273 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0564 | 0.4637 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0495 | 0.4057 | 0.4057 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0495 | 0.4057 | 0.4057 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1203 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.0495 | 0.4057 | 0.4057 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0088 | 0.0088 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0495 | 0.4057 | 0.4057 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0273 | 0.0405 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1203 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0387 | 0.0387 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0495 | 0.4057 | 0.4057 |
Loa Loa (eye worm) | hypothetical protein | 0.0495 | 0.4057 | 0.4057 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0088 | 0.5 |
Echinococcus multilocularis | protein patched | 0.0495 | 0.4057 | 0.4057 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.