Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.737 | 0.737 |
Echinococcus multilocularis | tryptophan hydroxylase | 0.0217 | 0.737 | 1 |
Loa Loa (eye worm) | integrin beta-2 | 0.0279 | 1 | 1 |
Toxoplasma gondii | aromatic amino acid hydrolase AAH2 | 0.0048 | 0.0223 | 0.5 |
Loa Loa (eye worm) | tryptophan hydroxylase 1 | 0.0048 | 0.0223 | 0.0223 |
Brugia malayi | Biopterin-dependent aromatic amino acid hydroxylase family protein | 0.0048 | 0.0223 | 0.0223 |
Toxoplasma gondii | phenylalanine-4-hydroxylase | 0.0048 | 0.0223 | 0.5 |
Leishmania major | phenylalanine-4-hydroxylase,phenylalanine-4-hydroxylase, putative | 0.0048 | 0.0223 | 0.5 |
Toxoplasma gondii | aromatic amino acid hydrolase AAH1 | 0.0048 | 0.0223 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0164 | 0.5152 | 1 |
Echinococcus granulosus | tryptophan hydroxylase | 0.0217 | 0.737 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.