Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thymidylate kinase | 0.0075 | 0.1327 | 0.5 |
Chlamydia trachomatis | thymidylate kinase | 0.0075 | 0.1327 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0229 | 0.0284 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0063 | 0.1036 | 0.1036 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0075 | 0.1327 | 0.236 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0053 | 0.0801 | 0.0727 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0073 | 0.128 | 0.9386 |
Trypanosoma brucei | RNA helicase, putative | 0.0436 | 1 | 1 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.003 | 0.0229 | 0.0284 |
Giardia lamblia | CDC8 | 0.0075 | 0.1327 | 0.159 |
Brugia malayi | RNase H family protein | 0.0043 | 0.0564 | 0.0063 |
Trichomonas vaginalis | ribonuclease H1, putative | 0.0043 | 0.0564 | 0.0916 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0075 | 0.1327 | 1 |
Loa Loa (eye worm) | thymidylate kinase | 0.0075 | 0.1327 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.3224 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0053 | 0.0801 | 0.0727 |
Brugia malayi | RNase H family protein | 0.0043 | 0.0564 | 0.0063 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0045 | 0.0604 | 0.0085 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0075 | 0.1327 | 0.236 |
Toxoplasma gondii | ribonuclease HI protein | 0.0043 | 0.0564 | 0.0063 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.5363 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.5363 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0243 | 0.5363 | 1 |
Giardia lamblia | Thymidine kinase | 0.0243 | 0.5363 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0243 | 0.5363 | 1 |
Mycobacterium ulcerans | thymidylate kinase | 0.0075 | 0.1327 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.128 | 0.839 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0053 | 0.08 | 0.3105 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0075 | 0.1327 | 0.236 |
Leishmania major | thymidylate kinase-like protein | 0.0075 | 0.1327 | 0.236 |
Schistosoma mansoni | thymidylate kinase | 0.0075 | 0.1327 | 0.1327 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0075 | 0.1327 | 0.1257 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0053 | 0.0801 | 0.0727 |
Echinococcus multilocularis | Metazoa galactosyltransferase | 0.0063 | 0.1036 | 0.6188 |
Brugia malayi | RNase H family protein | 0.0043 | 0.0564 | 0.0063 |
Brugia malayi | Galactosyltransferase family protein | 0.0063 | 0.1036 | 0.6211 |
Toxoplasma gondii | thymidylate kinase | 0.0075 | 0.1327 | 1 |
Echinococcus granulosus | thymidylate kinase | 0.0075 | 0.1327 | 1 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0043 | 0.0564 | 0.0916 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0053 | 0.08 | 0.3105 |
Schistosoma mansoni | thymidylate kinase | 0.0075 | 0.1327 | 0.1327 |
Schistosoma mansoni | phosphoglucomutase | 0.0043 | 0.0564 | 0.0564 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0075 | 0.1327 | 1 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0075 | 0.1327 | 0.5 |
Echinococcus multilocularis | Metazoa galactosyltransferase | 0.0053 | 0.0801 | 0.311 |
Brugia malayi | thymidylate kinase | 0.0075 | 0.1327 | 1 |
Trypanosoma brucei | ribonuclease H1 | 0.0043 | 0.0564 | 0.0488 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0053 | 0.08 | 0.08 |
Schistosoma mansoni | phosphoglucomutase | 0.0043 | 0.0564 | 0.0564 |
Trypanosoma brucei | unspecified product | 0.0053 | 0.0801 | 0.0727 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0075 | 0.1327 | 0.1257 |
Trypanosoma brucei | thymidine kinase | 0.0243 | 0.5363 | 0.5326 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0075 | 0.1327 | 0.236 |
Entamoeba histolytica | thymidine kinase, putative | 0.0243 | 0.5363 | 1 |
Echinococcus multilocularis | thymidylate kinase | 0.0075 | 0.1327 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.1327 | 0.1327 |
Plasmodium vivax | thymidylate kinase, putative | 0.0075 | 0.1327 | 1 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.003 | 0.0229 | 0.0284 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0075 | 0.1327 | 1 |
Leishmania major | thymidine kinase, putative | 0.0243 | 0.5363 | 1 |
Echinococcus multilocularis | Ribosomal protein L34a | 0.0047 | 0.0638 | 0.0973 |
Trypanosoma cruzi | ribonuclease H1, putative | 0.0043 | 0.0564 | 0.0916 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0053 | 0.0801 | 0.0727 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0063 | 0.1036 | 0.1036 |
Schistosoma mansoni | phosphoglucomutase | 0.0043 | 0.0564 | 0.0564 |
Echinococcus granulosus | Ribosomal protein L34a | 0.0047 | 0.0638 | 0.0973 |
Echinococcus granulosus | Metazoa galactosyltransferase | 0.0063 | 0.1036 | 0.6188 |
Leishmania major | ribonuclease H1, putative | 0.0043 | 0.0564 | 0.0916 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.5363 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.