Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, alpha | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.1267 | 1 |
Onchocerca volvulus | Deterin homolog | 0.11 | 0.8668 | 1 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0102 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0102 | 0.5 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.11 | 0.8668 | 1 |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0193 | 0.1267 | 0.1462 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0193 | 0.1267 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0414 | 0.3069 | 0.3541 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.11 | 0.8668 | 1 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0414 | 0.3069 | 0.3541 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.005 | 0.0102 | 0.5 |
Echinococcus granulosus | protein prenyltransferase alpha subunit | 0.005 | 0.0102 | 0.0117 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.1267 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.11 | 0.8668 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1264 | 1 | 1 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0102 | 0.5 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0193 | 0.1267 | 1 |
Echinococcus granulosus | geranylgeranyl transferase type 2 subunit alpha | 0.005 | 0.0102 | 0.0117 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.11 | 0.8668 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1267 | 0.1267 |
Onchocerca volvulus | 0.11 | 0.8668 | 1 | |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0143 | 0.0859 | 0.65 |
Trypanosoma cruzi | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0102 | 0.5 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.1267 | 0.1462 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.11 | 0.8668 | 1 |
Echinococcus multilocularis | protein prenyltransferase alpha subunit | 0.005 | 0.0102 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.11 | 0.8668 | 0.8668 |
Brugia malayi | hypothetical protein | 0.0414 | 0.3069 | 0.3541 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0193 | 0.1267 | 1 |
Leishmania major | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0102 | 0.5 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0193 | 0.1267 | 0.1267 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0193 | 0.1267 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.005 | 0.0102 | 0.5 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0193 | 0.1267 | 0.1462 |
Onchocerca volvulus | 0.0414 | 0.3069 | 0.3541 | |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0193 | 0.1267 | 1 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.005 | 0.0102 | 0.0117 |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.005 | 0.0102 | 0.0102 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0414 | 0.3069 | 0.3541 |
Brugia malayi | Cell death protein 3 precursor | 0.0414 | 0.3069 | 0.3541 |
Echinococcus granulosus | caspase 2 | 0.0414 | 0.3069 | 0.3541 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.11 | 0.8668 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0414 | 0.3069 | 0.3541 |
Onchocerca volvulus | 0.005 | 0.0102 | 0.0117 | |
Toxoplasma gondii | hypothetical protein | 0.0143 | 0.0859 | 1 |
Echinococcus multilocularis | geranylgeranyl transferase type 2 subunit alpha | 0.005 | 0.0102 | 0.0117 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0414 | 0.3069 | 0.3541 |
Trypanosoma brucei | protein farnesyltransferase alpha subunit, putative | 0.005 | 0.0102 | 0.5 |
Echinococcus multilocularis | caspase 2 | 0.0414 | 0.3069 | 0.3541 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.005 | 0.0102 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.3069 | 0.3069 |
Loa Loa (eye worm) | hypothetical protein | 0.11 | 0.8668 | 0.8668 |
Trypanosoma brucei | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0102 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.11 | 0.8668 | 1 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0193 | 0.1267 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.3069 | 0.3069 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.11 | 0.8668 | 1 |
Schistosoma mansoni | hypothetical protein | 0.11 | 0.8668 | 1 |
Trypanosoma cruzi | Protein prenyltransferase alpha subunit repeat, putative | 0.005 | 0.0102 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24 nM | Inhibition of purified recombinant human farnesyltransferase (FT) | ChEMBL. | 11020273 |
IC50 (binding) | = 24 nM | Inhibition of purified recombinant human farnesyltransferase (FT) | ChEMBL. | 11020273 |
Reversion (functional) | = 70 % | Percent phenotypic reversion of H-ras transformed Rat-1 cells at 10 microM | ChEMBL. | 11020273 |
Reversion (functional) | = 70 % | Percent phenotypic reversion of H-ras transformed Rat-1 cells at 10 microM | ChEMBL. | 11020273 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.