Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein arginine methyltransferase 6 | Starlite/ChEMBL | References |
Homo sapiens | protein arginine methyltransferase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | histone-arginine methyltransferase CARM1, putative | protein arginine methyltransferase 6 | 375 aa | 353 aa | 25.8 % |
Toxoplasma gondii | histone arginine methyltransferase PRMT4/CARM1 | protein arginine methyltransferase 8 | 385 aa | 345 aa | 33.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0047 | 0.475 | 1 |
Echinococcus multilocularis | protein arginine methyltransferase | 0.0047 | 0.475 | 0.5 |
Leishmania major | arginine N-methyltransferase-like protein | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | protein arginine N methyltransferase 8 | 0.0047 | 0.475 | 0.5 |
Echinococcus multilocularis | protein arginine N methyltransferase 8 | 0.0047 | 0.475 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0058 | 1 | 0.5 |
Plasmodium vivax | protein arginine N-methyltransferase 1, putative | 0.0047 | 0.475 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0058 | 1 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0047 | 0.475 | 1 |
Trypanosoma brucei | Protein arginine N-methyltransferase 1 catalytic subunit | 0.0058 | 1 | 0.5 |
Trypanosoma cruzi | arginine N-methyltransferase, putative | 0.0058 | 1 | 0.5 |
Schistosoma mansoni | protein arginine N-methyltransferase 1 | 0.0047 | 0.475 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 1 | 0.5 |
Echinococcus granulosus | protein arginine methyltransferase | 0.0047 | 0.475 | 0.5 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0058 | 1 | 0.5 |
Toxoplasma gondii | histone arginine methyltransferase PRMT1 | 0.0047 | 0.475 | 0.5 |
Plasmodium falciparum | protein arginine N-methyltransferase 1 | 0.0047 | 0.475 | 0.5 |
Trichomonas vaginalis | protein arginine N-methyltransferase, putative | 0.0047 | 0.475 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.004 uM | Inhibition of N-terminal GST tagged full-length human PRMT1 expressed in high five insect cells pre-incubated for 30 mins before addition of a [3H]SAM and peptide mix | ChEMBL. | 26101569 |
IC50 (binding) | = 0.007 uM | Inhibition of FLAG and hexa-histidine tagged full-length human PRMT6 expressed in HEK293F cells pre-incubated for 30 mins before addition of a [3H]SAM and peptide mix | ChEMBL. | 26101569 |
IC50 (binding) | = 0.01 uM | Inhibition of N-terminal GST tagged full-length human PRMT8 expressed in Escherichia coli (BL21(DE3) pre-incubated for 30 mins before addition of a [3H]SAM and peptide mix | ChEMBL. | 26101569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.