Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcium binding EGF domain containing protein | 0.0274 | 0.2325 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0874 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0247 | 0.1957 | 1 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0107 | 0.0093 | 0.0398 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0874 | 0.5 |
Brugia malayi | Fibulin-1 precursor | 0.0274 | 0.2325 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0274 | 0.2325 | 0.5 |
Brugia malayi | astacin protease protein 30 | 0.0107 | 0.0093 | 0.0398 |
Brugia malayi | Nematode astacin protease protein 30 | 0.0107 | 0.0093 | 0.0398 |
Schistosoma mansoni | egf-like domain protein | 0.0247 | 0.1957 | 0.1187 |
Brugia malayi | Zinc metalloproteinase toh-2 precursor | 0.0107 | 0.0093 | 0.0398 |
Echinococcus multilocularis | laminin | 0.0274 | 0.2325 | 0.159 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.0874 | 0.3757 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.1957 | 0.1957 |
Loa Loa (eye worm) | zinc metalloproteinase toh-2 | 0.0107 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | AStacin protease | 0.0531 | 0.5754 | 0.5754 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0247 | 0.1957 | 0.8416 |
Onchocerca volvulus | 0.0107 | 0.0093 | 0.0473 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0274 | 0.2325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.0874 | 0.0874 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.085 | 1 | 1 |
Brugia malayi | zinc metalloproteinase toh-2 precursor | 0.0107 | 0.0093 | 0.0398 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.0874 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0247 | 0.1957 | 0.1957 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.0874 | 0.5 |
Loa Loa (eye worm) | DPY-31 protein | 0.0107 | 0.0093 | 0.0093 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.0874 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.085 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0815 | 0.9539 | 0.9539 |
Loa Loa (eye worm) | hypothetical protein | 0.0346 | 0.3285 | 0.3285 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.085 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0274 | 0.2325 | 0.2325 |
Loa Loa (eye worm) | hypothetical protein | 0.0274 | 0.2325 | 0.2325 |
Echinococcus granulosus | laminin | 0.0274 | 0.2325 | 0.159 |
Echinococcus multilocularis | fibrillin 1 | 0.0274 | 0.2325 | 0.159 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0093 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.1957 | 0.1957 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 nM | Inhibition of rat liver microsomal HMG-CoA reductase | ChEMBL. | 8246234 |
IC50 (binding) | = 2 nM | Inhibition of rat liver microsomal HMG-CoA reductase | ChEMBL. | 8246234 |
logD | = 2.57 | Lipophilicity of the compound was determined | ChEMBL. | 8246234 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.