Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, kappa 1 | Starlite/ChEMBL | References |
Rattus norvegicus | Mu opioid receptor | Starlite/ChEMBL | References |
Mus musculus | opioid receptor, delta 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | Get druggable targets OG5_139759 | All targets in OG5_139759 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Mu opioid receptor | 398 aa | 376 aa | 26.3 % | |
Onchocerca volvulus | Mu opioid receptor | 398 aa | 333 aa | 26.4 % | |
Schistosoma mansoni | neuropeptide F-like receptor | Mu opioid receptor | 398 aa | 335 aa | 20.6 % |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Mu opioid receptor | 398 aa | 334 aa | 24.9 % |
Echinococcus multilocularis | allatostatin A receptor | Mu opioid receptor | 398 aa | 341 aa | 29.3 % |
Schistosoma japonicum | Rhodopsin, putative | Mu opioid receptor | 398 aa | 328 aa | 23.2 % |
Onchocerca volvulus | Programmed cell death protein 5 homolog | Mu opioid receptor | 398 aa | 323 aa | 24.1 % |
Echinococcus granulosus | allatostatin A receptor | Mu opioid receptor | 398 aa | 346 aa | 29.5 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Mu opioid receptor | 398 aa | 370 aa | 27.3 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Mu opioid receptor | 398 aa | 371 aa | 27.0 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Mu opioid receptor | 398 aa | 397 aa | 22.7 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Mu opioid receptor | 398 aa | 334 aa | 23.1 % |
Onchocerca volvulus | Mu opioid receptor | 398 aa | 356 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glutathione reductase, putative | 0.0043 | 0.0105 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0099 | 0.1039 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.1347 | 0.471 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.286 | 1 |
Brugia malayi | glutathione reductase | 0.0043 | 0.0105 | 0.0369 |
Schistosoma mansoni | eyes absent homolog | 0.0208 | 0.286 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0044 | 0.0115 | 0.0115 |
Plasmodium falciparum | thioredoxin reductase | 0.0043 | 0.0105 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0043 | 0.0105 | 0.0369 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0099 | 0.1039 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.011 | 0.1225 | 1 |
Brugia malayi | hypothetical protein | 0.0208 | 0.286 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.011 | 0.1225 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.286 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0099 | 0.1039 | 0.8342 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0118 | 0.1347 | 0.471 |
Loa Loa (eye worm) | glutathione reductase | 0.0043 | 0.0105 | 0.0369 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0724 | 0.253 |
Brugia malayi | Thioredoxin reductase | 0.0043 | 0.0105 | 0.0369 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0044 | 0.0115 | 0.0115 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0099 | 0.1039 | 0.8342 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0724 | 0.253 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0043 | 0.0105 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.011 | 0.1225 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0099 | 0.1039 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0099 | 0.1039 | 0.8342 |
Leishmania major | trypanothione reductase | 0.0043 | 0.0105 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.0724 | 0.253 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0634 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0118 | 0.1347 | 0.471 |
Toxoplasma gondii | thioredoxin reductase | 0.0043 | 0.0105 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0043 | 0.0105 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0043 | 0.0105 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0118 | 0.1347 | 0.471 |
Trypanosoma brucei | trypanothione reductase | 0.0043 | 0.0105 | 0.5 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.011 | 0.1225 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 19.2 nM | Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding | ChEMBL. | 26330078 |
Emax (binding) | = 123 % | Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding relative to U50,488H | ChEMBL. | 26330078 |
Inhibition (binding) | > 50 % | Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes at 3 uM | ChEMBL. | 26330078 |
Inhibition (binding) | > 50 % | Displacement of [3H]diprenorphine from FLAG-tagged mouse delta opioid receptor expressed in CHO cell membranes Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes at 3 uM | ChEMBL. | 26330078 |
Inhibition (binding) | > 50 % | Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in CHO cell membranes Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes at 3 uM | ChEMBL. | 26330078 |
Ki (binding) | = 4.7 nM | Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes | ChEMBL. | 26330078 |
Ki (binding) | > 1000 nM | Displacement of [3H]diprenorphine from FLAG-tagged mouse delta opioid receptor expressed in CHO cell membranes | ChEMBL. | 26330078 |
Ki (binding) | > 1000 nM | Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in CHO cell membranes | ChEMBL. | 26330078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.