TDR Targets

Basic information

Technical information

TDR Targets ID: 21034
Name: 2-amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxyme thyl)oxolan-2-yl]-3H-purin-6-one
MW: 362.137 | Formula: C10H12BrN5O5
H donors: 5 H acceptors: 7 LogP: -0.9 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: OCC1OC(C(C1O)O)n1c(Br)nc2c1nc(N)nc2O
InChi: 1S/C10H12BrN5O5/c11-9-13-3-6(14-10(12)15-7(3)20)16(9)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H3,12,14,15,20)
InChiKey: ASUCSHXLTWZYBA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
2-amino-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3H-purin-6-one
2-azanyl-8-bromo-9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
2-amino-8-bromo-9-(3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl)-3H-purin-6-one
8-bromoguanosine
4016-63-1
8 BrGuo
NSC79211
NCGC00096092-01
CBDivE_001621
Oprea1_809319
TULIP028888
BAS 00119951
NSC174257

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0207	0.0207
Trypanosoma brucei	AMP deaminase, putative	0.1484	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.004	0.0207	0.0207
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0207	0.0207
Brugia malayi	putative neuropeptide receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0041	0.0218	0.0218
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.004	0.0207	0.0207
Echinococcus granulosus	g protein coupled receptor	0.004	0.0207	0.0207
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.137	0.9224	0.9217
Echinococcus multilocularis	allatostatin A receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Brugia malayi	AKH receptor	0.004	0.0207	0.0207
Trypanosoma cruzi	AMP deaminase, putative	0.1484	1	1
Schistosoma mansoni	amine GPCR	0.004	0.0207	0.0207
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0207	0.0117
Plasmodium falciparum	AMP deaminase, putative	0.1484	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus multilocularis	serotonin receptor	0.004	0.0207	0.0207
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0207	0.0207
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0207	0.0207
Brugia malayi	Dopamine receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	G protein coupled receptor 139	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	neuropeptide s receptor	0.004	0.0207	0.0207
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0207	0.0207
Echinococcus granulosus	allatostatin A receptor	0.004	0.0207	0.0207
Brugia malayi	neuropeptide F receptor	0.004	0.0207	0.0207
Brugia malayi	RE15519p	0.004	0.0207	0.0207
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.004	0.0207	0.0117
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	TYRA-2 protein	0.004	0.0207	0.0117
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0041	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0641	0.4285	0.4232
Trypanosoma cruzi	adenosine monophosphate deaminase, putative	0.1484	1	1
Onchocerca volvulus	Adenosine deaminase homolog	0.137	0.9224	0.9208
Echinococcus granulosus	alpha 1A adrenergic receptor	0.004	0.0207	0.0207
Brugia malayi	Serotonin receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	dro:myosuppressin receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.004	0.0207	0.0207
Echinococcus granulosus	g-protein coupled receptor	0.004	0.0207	0.0207
Echinococcus granulosus	tachykinin peptides receptor 99D	0.004	0.0207	0.0207
Schistosoma mansoni	neuropeptide f receptor 76f	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Treponema pallidum	adenosine deaminase	0.137	0.9224	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0041	0.0218	0.0218
Brugia malayi	Dopamine receptor protein 2	0.004	0.0207	0.0207
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.0207	0.0207
Brugia malayi	Serotonin receptor	0.004	0.0207	0.0207
Toxoplasma gondii	Adenosine/AMP deaminase domain-containing protein	0.137	0.9224	0.9217
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Schistosoma mansoni	hypothetical protein	0.004	0.0207	0.0207
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.004	0.0207	0.0207
Schistosoma mansoni	histamine h1 receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Brugia malayi	G protein-coupled receptor F59B2.13	0.004	0.0207	0.0207
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0207	0.0207
Brugia malayi	G-protein coupled receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Plasmodium falciparum	adenosine deaminase	0.137	0.9224	0.9217
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.004	0.0207	0.0117
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0041	0.0218	0.0218
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.004	0.0207	0.0207
Echinococcus granulosus	g protein coupled receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0218	0.0218
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0218	0.0218
Schistosoma mansoni	myosin xvIII	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Entamoeba histolytica	adenosine deaminase, putative	0.137	0.9224	0.9217
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Entamoeba histolytica	adenosine deaminase, putative	0.137	0.9224	0.9217
Schistosoma mansoni	neuropeptide receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0641	0.4285	0.4232
Trypanosoma brucei	AMP deaminase, putative	0.1484	1	1
Schistosoma mansoni	neuropeptide receptor	0.004	0.0207	0.0207
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.004	0.0207	0.0207
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.004	0.0207	0.0207
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.004	0.0207	0.0207
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0207	0.0207
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Brugia malayi	SRC-1	0.0041	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Trypanosoma cruzi	AMP deaminase 2, putative	0.0728	0.4876	0.4829
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Brugia malayi	GnHR receptor homolog	0.004	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0041	0.0218	0.0218
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	neuropeptide receptor A26	0.004	0.0207	0.0207
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0091	0.0091
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Mycobacterium ulcerans	adenosine deaminase	0.137	0.9224	1
Trypanosoma cruzi	AMP deaminase, putative	0.1484	1	1
Schistosoma mansoni	amine GPCR	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0207	0.0117
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0036	0.0183	0.0183
Loa Loa (eye worm)	TK protein kinase	0.0033	0.0162	0.0072
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0041	0.0218	0.0218
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.004	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0041	0.0218	0.0218
Leishmania major	AMP deaminase, putative,amp deaminase-like protein	0.1484	1	1
Brugia malayi	ORL1-like opioid receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	opsin-like receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0091	0.0091
Onchocerca volvulus	AMP deaminase 2 homolog	0.1484	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Brugia malayi	G-protein coupled receptor	0.004	0.0207	0.0207
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0041	0.0218	0.0218
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	somatostatin receptor	0.004	0.0207	0.0207
Echinococcus granulosus	somatostatin receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.0091	0.5
Echinococcus granulosus	neuropeptide receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	AMP deaminase	0.1484	1	1
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	AMP deaminase 2	0.1484	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.004	0.0207	0.0117
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Brugia malayi	G protein-coupled receptor	0.004	0.0207	0.0207
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0091	0.0091
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Brugia malayi	putative neuropeptide receptor NPR1	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0041	0.0218	0.0218
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0207	0.0207
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	hypothetical protein	0.004	0.0207	0.0207
Trypanosoma brucei	AMP deaminase, putative	0.1484	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0041	0.0218	0.0218
Toxoplasma gondii	AMP deaminase	0.1484	1	1
Echinococcus granulosus	neuropeptide receptor A26	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.137	0.9224	0.9217
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0207	0.0207
Echinococcus granulosus	adenosine deaminase	0.137	0.9224	0.9224
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.004	0.0207	0.0207
Echinococcus granulosus	G protein coupled receptor 139	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0207	0.0207
Echinococcus multilocularis	serotonin receptor	0.004	0.0207	0.0207
Schistosoma mansoni	tyrosine kinase	0.0041	0.0218	0.0218
Brugia malayi	sulfakinin receptor protein	0.004	0.0207	0.0207
Onchocerca volvulus		0.0728	0.4876	0.4768
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0728	0.4876	0.4829
Echinococcus granulosus	orexin receptor type 2	0.004	0.0207	0.0207
Leishmania major	adenosine monophosphate deaminase, putative,AMP deaminase, putative	0.1484	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	hypothetical protein	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	AMP deaminase	0.1484	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0207	0.0207
Brugia malayi	Melatonin receptor type 1A	0.004	0.0207	0.0207
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0041	0.0218	0.0218
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.004	0.0207	0.0207
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Entamoeba histolytica	protein kinase, putative	0.0033	0.0162	0.0072
Schistosoma mansoni	biogenic amine receptor	0.004	0.0207	0.0207
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0041	0.0218	0.0218
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Echinococcus granulosus	neuropeptide receptor	0.004	0.0207	0.0207
Schistosoma mansoni	amine GPCR	0.004	0.0207	0.0207
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.004	0.0207	0.0207
Schistosoma mansoni	tyrosine kinase	0.0041	0.0218	0.0218
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.004	0.0207	0.0207
Schistosoma mansoni	ap endonuclease	0.0023	0.0091	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0756	0.506	0.5015
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0037	0.019	0.019
Loa Loa (eye worm)	TK protein kinase	0.0037	0.019	0.0101
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.004	0.0207	0.0117
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0207	0.0117
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	neuropeptide FF receptor 2	0.004	0.0207	0.0207
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Trichomonas vaginalis	adenosine deaminase, putative	0.137	0.9224	1
Echinococcus granulosus	7tm_1 domain containing protein	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0207	0.0207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Schistosoma mansoni	biogenic amine receptor	0.004	0.0207	0.0207
Trypanosoma cruzi	AMP deaminase, putative	0.1484	1	1
Trypanosoma cruzi	adenosine monophosphate deaminase-like protein, putative	0.1484	1	1
Schistosoma mansoni	neuropeptide receptor	0.004	0.0207	0.0207
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Echinococcus granulosus	neuropeptide FF receptor 2	0.004	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Echinococcus multilocularis	G-protein coupled receptor, putative	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0037	0.019	0.019
Entamoeba histolytica	AMP deaminase, putative	0.1484	1	1
Trypanosoma cruzi	AMP deaminase, putative	0.1484	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0207	0.0207
Echinococcus granulosus	dro:myosuppressin receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Leishmania major	AMP deaminase, putative,adenosine monophosphate deaminase-like protein	0.1484	1	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0037	0.019	0.019
Trichomonas vaginalis	adenosine deaminase, putative	0.137	0.9224	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Leishmania major	adenine aminohydrolase	0.137	0.9224	0.9217
Brugia malayi	Adenosine/AMP deaminase family protein	0.137	0.9224	0.9224
Echinococcus granulosus	hypothetical protein	0.004	0.0207	0.0207
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0207	0.0207
Schistosoma mansoni	hypothetical protein	0.004	0.0207	0.0207
Loa Loa (eye worm)	melatonin receptor type 1A	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Brugia malayi	protein-tyrosine kinase	0.0037	0.019	0.019
Brugia malayi	follicle stimulating hormone receptor	0.004	0.0207	0.0207
Trypanosoma brucei	adenosine monophosphate deaminase, putative	0.1484	1	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0641	0.4285	0.4232
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0207	0.0207
Schistosoma mansoni	opsin-like receptor	0.004	0.0207	0.0207
Brugia malayi	neuropeptide F receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Mycobacterium leprae	Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)	0.137	0.9224	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0041	0.0218	0.0218
Echinococcus granulosus	tyrosine protein kinase HCK	0.0033	0.0162	0.0162
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	serotonin receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0207	0.0207
Schistosoma mansoni	adenoreceptor	0.004	0.0207	0.0207
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0041	0.0218	0.0218
Plasmodium vivax	adenosine deaminase, putative	0.137	0.9224	0.9217
Echinococcus multilocularis	sex peptide receptor	0.004	0.0207	0.0207
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.0207	0.0207
Echinococcus granulosus	neuropeptide s receptor	0.004	0.0207	0.0207
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0207	0.0207
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0023	0.0091	0.5
Schistosoma mansoni	adenosine deaminase-related	0.137	0.9224	0.9224
Brugia malayi	Dopamine receptor protein 1	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0207	0.0207
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0033	0.0162	0.0162
Echinococcus multilocularis	adenosine deaminase	0.137	0.9224	0.9224
Echinococcus multilocularis	g-protein coupled receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0041	0.0218	0.0218
Schistosoma mansoni	alpha-1 adrenergic receptor	0.004	0.0207	0.0207
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0207	0.0207
Schistosoma mansoni	amine GPCR	0.004	0.0207	0.0207
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Echinococcus granulosus	sex peptide receptor	0.004	0.0207	0.0207
Leishmania major	hypothetical protein, conserved	0.0728	0.4876	0.4829
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.004	0.0207	0.0207
Schistosoma mansoni	opsin-like receptor	0.004	0.0207	0.0207
Echinococcus granulosus	fmrfamide receptor	0.004	0.0207	0.0207
Echinococcus granulosus	7TM GPCR rhodopsin	0.004	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Echinococcus granulosus	peptide allatostatin:somatostatin	0.004	0.0207	0.0207
Brugia malayi	larval opioid receptor	0.004	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Brugia malayi	hypothetical protein	0.004	0.0207	0.0207
Schistosoma mansoni	adenosine deaminase	0.137	0.9224	0.9224
Echinococcus granulosus	tyrosine kinase	0.0037	0.019	0.019
Trypanosoma cruzi	AMP deaminase, putative	0.1484	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Schistosoma mansoni	ap endonuclease	0.0023	0.0091	0.0091
Mycobacterium tuberculosis	Probable adenosine deaminase Add (adenosine aminohydrolase)	0.137	0.9224	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0641	0.4285	0.4232
Echinococcus multilocularis	AMP deaminase 2	0.1484	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Brugia malayi	Tachykinin-like peptides receptor 99D	0.004	0.0207	0.0207
Entamoeba histolytica	AMP deaminase, putative	0.1484	1	1
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0207	0.0207
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0036	0.0183	0.0183
Leishmania major	AMP deaminase, putative	0.1484	1	1
Schistosoma mansoni	neuropeptide receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0207	0.0207
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	SRC-1	0.0041	0.0218	0.0129
Schistosoma mansoni	biogenic amine receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus granulosus	g protein coupled receptor	0.004	0.0207	0.0207
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.004	0.0207	0.0207
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.004	0.0207	0.0117
Echinococcus granulosus	tyrosine protein kinase Blk	0.0037	0.019	0.019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0207	0.0207
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.004	0.0207	0.0207
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.004	0.0207	0.0207
Schistosoma mansoni	amine GPCR	0.004	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0037	0.019	0.019
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Loa Loa (eye worm)	hypothetical protein	0.004	0.0207	0.0117
Echinococcus multilocularis	orexin receptor type 2	0.004	0.0207	0.0207
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.004	0.0207	0.0207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0207	0.0207
Plasmodium vivax	adenosine/AMP deaminase, putative	0.1484	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Benzidine positive cells (functional)	= 6 %	Inhibitory activity against cellular differentiation in Friend erythroleukemia cells as percentage of benzidine - positive cells.	ChEMBL.	3861870
ID50 (functional)	= 5.1 mM	Inhibitory activity against cellular replication in Friend erythroleukemia cells as growth inhibition.	ChEMBL.	3861870
ID50 (functional)	= 5.1 mM	Inhibitory activity against cellular replication in hypoxanthine-guanine phosphoribosyltransferase (HGPRT-) HL-60 cells.	ChEMBL.	3861870
Optimal concentration (functional)	= 5 mM	Inhibitory activity against cellular differentiation in Friend erythroleukemia cells as optimal concentration required for maximum activity.	ChEMBL.	3861870
Potency (functional)	0.0028 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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PubChem: 254686
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Bibliographic References

6 literature references were collected for this gene.

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Detailed information for compound 21034