Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vanilloid receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0861 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0417 | 0.4755 | 0.3468 |
Echinococcus multilocularis | lamin | 0.0032 | 0.0193 | 0.0248 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0193 | 0.0224 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0671 | 0.776 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0671 | 0.776 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0671 | 0.776 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.0193 | 0.0248 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0861 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0671 | 0.776 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0861 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0186 | 0.024 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0417 | 0.4755 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0139 | 0.147 | 0.1873 |
Echinococcus multilocularis | thymidylate synthase | 0.0671 | 0.776 | 1 |
Onchocerca volvulus | 0.0671 | 0.776 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0319 | 0.3597 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0671 | 0.776 | 1 |
Mycobacterium ulcerans | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | 0.0282 | 0.316 | 0.3872 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0861 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0193 | 0.0248 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0671 | 0.776 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0193 | 0.0248 |
Schistosoma mansoni | aspartate carbamoyltransferase | 0.0037 | 0.0254 | 0.0081 |
Wolbachia endosymbiont of Brugia malayi | AICAR transformylase/IMP cyclohydrolase PurH | 0.0282 | 0.316 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0417 | 0.4755 | 0.6118 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0417 | 0.4755 | 0.6128 |
Echinococcus granulosus | dihydrofolate reductase | 0.0417 | 0.4755 | 0.6128 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.0193 | 0.0248 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0319 | 0.3597 | 0.095 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0417 | 0.4755 | 0.5997 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0417 | 0.4755 | 0.6128 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0861 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0193 | 0.0224 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.002 | 0.0025 |
Brugia malayi | dihydrofolate reductase family protein | 0.0417 | 0.4755 | 0.6118 |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.0193 | 0.0248 |
Echinococcus multilocularis | musashi | 0.0032 | 0.0193 | 0.0248 |
Brugia malayi | hypothetical protein | 0.0319 | 0.3597 | 0.4622 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0193 | 0.0248 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0139 | 0.147 | 0.1894 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0139 | 0.147 | 0.1894 |
Mycobacterium ulcerans | thymidylate synthase | 0.0671 | 0.776 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0417 | 0.4755 | 0.6029 |
Echinococcus granulosus | lamin | 0.0032 | 0.0193 | 0.0248 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0417 | 0.4755 | 0.3468 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.9 nM | Vanilloid receptor subtype 1 antagonist activity based on its ability to block capsaicin-induced (CAP) activation of the rat VR1 channel in a HEK293 cell line | ChEMBL. | 14505681 |
IC50 (functional) | = 3.9 nM | Vanilloid receptor subtype 1 antagonist activity based on its ability to block capsaicin-induced (CAP) activation of the rat VR1 channel in a HEK293 cell line | ChEMBL. | 14505681 |
IC50 (functional) | = 17.2 nM | Vanilloid receptor subtype 1 antagonist activity based on its ability to block low pH-induced activation of the rat VR1 channel in a HEK293 cell line | ChEMBL. | 14505681 |
IC50 (functional) | = 17.2 nM | Vanilloid receptor subtype 1 antagonist activity based on its ability to block low pH-induced activation of the rat VR1 channel in a HEK293 cell line | ChEMBL. | 14505681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.