Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1189 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.5478 | 0.6132 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0743 | 0.5833 | 0.653 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 0.8934 | 1 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0567 | 0.4187 | 0.4187 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0142 | 0.0209 | 0.0234 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0938 | 0.7653 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.5478 | 0.6132 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0249 | 0.1211 | 0.1355 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 0.8934 | 1 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0567 | 0.4187 | 0.4187 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.5478 | 0.6132 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0567 | 0.4187 | 0.4151 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0142 | 0.0209 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 0.8934 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.1166 | 0.9791 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0142 | 0.0209 | 0.0234 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.1075 | 0.8934 | 0.8934 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0705 | 0.5478 | 0.8192 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 0.8934 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0142 | 0.0209 | 0.0209 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1189 | 1 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0142 | 0.0209 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0142 | 0.0209 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.5478 | 0.6132 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0142 | 0.0209 | 0.0234 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0142 | 0.0209 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0142 | 0.0209 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0142 | 0.0209 | 0.0234 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0743 | 0.5833 | 0.653 |
Schistosoma mansoni | alpha-glucosidase | 0.1166 | 0.9791 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0142 | 0.0209 | 0.0234 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 0.8934 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0142 | 0.0209 | 0.0234 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.5478 | 0.6132 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.1075 | 0.8934 | 0.8934 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1189 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0142 | 0.0209 | 1 |
Onchocerca volvulus | 0.0835 | 0.6688 | 1 | |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0249 | 0.1211 | 0.1355 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0938 | 0.7653 | 0.7603 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0142 | 0.0209 | 0.0234 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0142 | 0.0209 | 0.0209 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.5478 | 0.6132 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0142 | 0.0209 | 0.0234 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.5478 | 0.6132 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1189 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 0.8934 | 1 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0938 | 0.7653 | 0.7603 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0142 | 0.0209 | 0.0234 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0142 | 0.0209 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.007 uM | Antiviral activity was tested in absence of human serum in MT-4 cells (in vitro) | ChEMBL. | 14552751 |
EC50 (functional) | = 0.098 uM | Antiviral activity was tested in presence of 50% human serum in MT-4 cells (in vitro) | ChEMBL. | 14552751 |
Inhibition (binding) | = 92 % | Inhibitory activity against HIV protease at a compound concentration of 0.5 nM in MT-4 cells | ChEMBL. | 14552751 |
Inhibition (binding) | = 92 % | Inhibitory activity against HIV protease at a compound concentration of 0.5 nM in MT-4 cells | ChEMBL. | 14552751 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.