Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0905 | 0.123 | 0.31 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.494 | 1 | 1 |
Onchocerca volvulus | 0.1334 | 0.2161 | 0.1903 | |
Loa Loa (eye worm) | hypothetical protein | 0.1334 | 0.2161 | 0.2669 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0574 | 0.0511 | 0.0432 |
Mycobacterium ulcerans | hydrolase | 0.1144 | 0.175 | 0.4418 |
Schistosoma mansoni | endothelin-converting enzyme-related | 0.0437 | 0.0213 | 0.0353 |
Brugia malayi | Hemopexin family protein | 0.1715 | 0.2989 | 0.3804 |
Schistosoma mansoni | hypothetical protein | 0.0468 | 0.028 | 0.0536 |
Schistosoma mansoni | hypothetical protein | 0.1715 | 0.2989 | 0.7849 |
Loa Loa (eye worm) | hypothetical protein | 0.1326 | 0.2144 | 0.2646 |
Loa Loa (eye worm) | hypothetical protein | 0.1357 | 0.2212 | 0.2739 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Mycobacterium tuberculosis | Two component sensor histidine kinase DevS | 0.063 | 0.0631 | 0.1594 |
Onchocerca volvulus | 0.1715 | 0.2989 | 0.3534 | |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1794 | 0.3162 | 0.8315 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.1264 | 0.2009 | 0.2461 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0574 | 0.0511 | 0.0432 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1326 | 0.2144 | 0.2646 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1794 | 0.3162 | 0.3106 |
Toxoplasma gondii | peptidase family M13 protein | 0.1794 | 0.3162 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0574 | 0.0511 | 0.0408 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0786 | 0.0971 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0786 | 0.0971 | 1 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0905 | 0.123 | 0.31 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.1326 | 0.2144 | 0.2646 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Schistosoma mansoni | endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) | 0.0437 | 0.0213 | 0.0353 |
Loa Loa (eye worm) | matrixin family protein | 0.2478 | 0.4648 | 0.6075 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.0456 | 0.0253 | 0.0056 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0409 | 0.0152 | 1 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1794 | 0.3162 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Brugia malayi | Matrixin family protein | 0.1334 | 0.2161 | 0.2669 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.086 | 0.1132 | 0.2834 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Brugia malayi | Matrixin family protein | 0.1334 | 0.2161 | 0.2669 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0535 | 0.0426 | 0.0346 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0468 | 0.028 | 0.0536 |
Mycobacterium leprae | probable zinc metalloprotease | 0.1794 | 0.3162 | 1 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.1357 | 0.2212 | 0.2739 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Schistosoma mansoni | hypothetical protein | 0.0468 | 0.028 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.1326 | 0.2144 | 0.2646 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0905 | 0.123 | 0.31 |
Schistosoma mansoni | hypothetical protein | 0.0468 | 0.028 | 0.0536 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.1357 | 0.2212 | 0.2739 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0437 | 0.0213 | 0.0353 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0535 | 0.0426 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0889 | 0.1195 | 0.1345 |
Loa Loa (eye worm) | hypothetical protein | 0.1357 | 0.2212 | 0.2739 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0437 | 0.0213 | 0.0353 |
Brugia malayi | Matrixin family protein | 0.3796 | 0.7513 | 1 |
Trypanosoma cruzi | GAF domain/TIP41-like family, putative | 0.0409 | 0.0152 | 1 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.1412 | 0.2331 | 0.2901 |
Brugia malayi | Matrixin family protein | 0.1334 | 0.2161 | 0.2669 |
Schistosoma mansoni | hypothetical protein | 0.0468 | 0.028 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.1326 | 0.2144 | 0.2646 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.1334 | 0.2161 | 0.2669 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.2478 | 0.4648 | 0.68 |
Loa Loa (eye worm) | hypothetical protein | 0.1326 | 0.2144 | 0.2646 |
Trypanosoma brucei | GAF domain/TIP41-like family, putative | 0.0409 | 0.0152 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0437 | 0.0213 | 0.0353 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.1334 | 0.2161 | 0.2669 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0786 | 0.0971 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1144 | 0.175 | 0.5308 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.1794 | 0.3162 | 0.404 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1794 | 0.3162 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1794 | 0.3162 | 0.3106 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.1357 | 0.2212 | 0.2739 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.2081 | 0.3786 | 1 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0905 | 0.123 | 0.31 |
Loa Loa (eye worm) | matrixin family protein | 0.3796 | 0.7513 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.3226 | 0.6273 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0786 | 0.0971 | 1 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0527 | 0.0409 | 0.4212 |
Onchocerca volvulus | Matrilysin homolog | 0.1334 | 0.2161 | 0.1903 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0437 | 0.0213 | 0.0353 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0527 | 0.0409 | 0.4212 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0905 | 0.123 | 0.31 |
Loa Loa (eye worm) | hypothetical protein | 0.1264 | 0.2009 | 0.2461 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1794 | 0.3162 | 0.404 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 0.175 | 0.2105 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.1412 | 0.2331 | 0.2901 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Loa Loa (eye worm) | hypothetical protein | 0.2081 | 0.3786 | 0.4895 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1144 | 0.175 | 0.2105 |
Loa Loa (eye worm) | hypothetical protein | 0.1357 | 0.2212 | 0.2739 |
Loa Loa (eye worm) | hypothetical protein | 0.1794 | 0.3162 | 0.404 |
Schistosoma mansoni | hypothetical protein | 0.0468 | 0.028 | 0.0536 |
Loa Loa (eye worm) | hypothetical protein | 0.1794 | 0.3162 | 0.404 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0377 | 0.0082 | 0.0844 |
Schistosoma mansoni | neprilysin | 0.0468 | 0.028 | 0.0536 |
Leishmania major | hypothetical protein, conserved | 0.0409 | 0.0152 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.1794 | 0.3162 | 0.404 |
Brugia malayi | Matrixin family protein | 0.1334 | 0.2161 | 0.2669 |
Schistosoma mansoni | hypothetical protein | 0.0468 | 0.028 | 0.0536 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.1264 | 0.2009 | 0.5203 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 26 uM | Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours | ChEMBL. | 1433180 |
IC50 (functional) | = 26 uM | Concentration required to inhibit proliferation of cultured lymphoid leukemia L1210 cells to 50% growth over 48 hours | ChEMBL. | 1433180 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.