Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.3053 | 0.3053 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.22 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0456 | 0.0924 | 0.0924 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.082 | 0.2821 | 0.2821 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.1144 | 0.4504 | 0.3944 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1412 | 0.59 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1412 | 0.59 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.22 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.22 | 1 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.1144 | 0.4504 | 0.4504 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.3053 | 0.3053 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.1144 | 0.4504 | 0.3944 |
Loa Loa (eye worm) | hypothetical protein | 0.0567 | 0.1499 | 0.1499 |
Loa Loa (eye worm) | hypothetical protein | 0.0845 | 0.295 | 0.295 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0577 | 0.1554 | 0.1554 |
Loa Loa (eye worm) | thymidylate synthase | 0.0456 | 0.0924 | 0.0924 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.22 | 1 | 1 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0577 | 0.1554 | 0.1554 |
Onchocerca volvulus | 0.0567 | 0.1499 | 1 | |
Mycobacterium leprae | probable zinc metalloprotease | 0.1144 | 0.4504 | 0.3944 |
Loa Loa (eye worm) | hypothetical protein | 0.0845 | 0.295 | 0.295 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0456 | 0.0924 | 0.0924 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 0.4504 | 0.4504 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.1144 | 0.4504 | 0.4504 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 0.4504 | 0.4504 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.1144 | 0.4504 | 0.4504 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0577 | 0.1554 | 0.1554 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.0104 | 0.0104 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.22 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1412 | 0.59 | 0.5 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0845 | 0.295 | 0.295 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.22 | 1 | 1 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.1144 | 0.4504 | 0.3944 |
Brugia malayi | Angiotensin-converting enzyme family protein | 0.082 | 0.2821 | 0.2821 |
Mycobacterium ulcerans | zinc metalloprotease | 0.1144 | 0.4504 | 0.3944 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.3053 | 0.3053 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0845 | 0.295 | 0.295 |
Chlamydia trachomatis | dihydrofolate reductase | 0.22 | 1 | 0.5 |
Schistosoma mansoni | neprilysin | 0.0298 | 0.0104 | 0.0104 |
Schistosoma mansoni | dihydrofolate reductase | 0.22 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1412 | 0.59 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0298 | 0.0104 | 0.0104 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.3053 | 0.3053 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 0.4504 | 0.4504 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1412 | 0.59 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.0104 | 0.0104 |
Echinococcus granulosus | dihydrofolate reductase | 0.22 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.3053 | 0.3053 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0577 | 0.1554 | 0.1554 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0577 | 0.1554 | 0.1554 |
Loa Loa (eye worm) | hypothetical protein | 0.0865 | 0.3053 | 0.3053 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1412 | 0.59 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0845 | 0.295 | 0.295 |
Loa Loa (eye worm) | hypothetical protein | 0.0845 | 0.295 | 0.295 |
Schistosoma mansoni | hypothetical protein | 0.0298 | 0.0104 | 0.0104 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Concentration of the compound required to inhibit the mutant alpha-Ala HCMV protease by 50% was determined | ChEMBL. | 9871686 |
IC50 (binding) | > 100 uM | Concentration of the compound required to inhibit the mutant alpha-Ala HCMV protease by 50% was determined | ChEMBL. | 9871686 |
Inhibition (functional) | = 35 % | Compound was evaluated for antiviral activity measured as percentage inhibition determined at a concentration of 100 (microM) against mutant alpha-Ala HCMV protease | ChEMBL. | 9871686 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.