Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | farnesyltransferase, CAAX box, beta | References | |
Homo sapiens | farnesyltransferase, CAAX box, alpha | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.97 uM | Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay | ChEMBL. | 26774924 |
IC50 (functional) | > 25 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcB1/Columbia infected in human erythrocytes after 48 hrs by [3H]hypoxanthine incorporation assay | ChEMBL. | 26774924 |
IC50 (functional) | > 50 uM | Antiparasitic activity against bloodstream form of Trypanosoma brucei brucei 93 assessed as growth inhibition after 72 hrs by resazurin assay | ChEMBL. | 26774924 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.