Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | MIR domain protein | 0.0153 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0588 | 0.0971 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1438 | 0.6051 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0263 | 0.0519 | 0.0519 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0277 | 0.0588 | 0.0588 |
Brugia malayi | cation channel family protein | 0.0974 | 0.3864 | 0.3864 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0696 | 0.2559 | 0.2559 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0226 | 0.0347 | 0.0347 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0821 | 0.3146 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0226 | 0.0347 | 0.0436 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0226 | 0.0347 | 0.0436 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1438 | 0.6051 | 0.7602 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1438 | 0.6051 | 0.7602 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 0.1322 | 0.2184 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1844 | 0.796 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0226 | 0.0347 | 0.0347 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1844 | 0.796 | 1 |
Onchocerca volvulus | 0.0153 | 0 | 0.5 | |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0226 | 0.0347 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.1237 | 0.2045 |
Loa Loa (eye worm) | ryanodine receptor | 0.0537 | 0.1812 | 0.2994 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0226 | 0.0347 | 0.0436 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.0589 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.2277 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0226 | 0.0347 | 0.0436 |
Schistosoma mansoni | hypothetical protein | 0.0562 | 0.1925 | 0.1925 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0558 | 0.1909 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0226 | 0.0347 | 0.0573 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0226 | 0.0347 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0821 | 0.3146 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0851 | 0.3286 | 0.543 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Agonist activity at mouse TRPM8 expressed in HEK293 cells assessed as increase in calcium flux at 50 uM after 60 mins by Fluo-4 NW dye based fluorometric assay | ChEMBL. | 26847872 | |
FC (binding) | = 3 | Agonist activity at mouse TRPM8 expressed in HEK293 cells assessed as increase in calcium flux at 50 uM after 60 mins by Fluo-4 NW dye based fluorometric assay relative to menthol | ChEMBL. | 26847872 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.