Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | casein kinase 2, alpha prime polypeptide | No references | |
Homo sapiens | PAS domain containing serine/threonine kinase | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | casein kinase II, alpha chain, putative | casein kinase 2, alpha prime polypeptide | 350 aa | 319 aa | 50.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0082 | 1 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0082 | 1 | 0.5 |
Plasmodium vivax | unspecified product | 0.0082 | 1 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0082 | 1 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Entamoeba histolytica | casein kinase, putative | 0.0082 | 1 | 0.5 |
Onchocerca volvulus | 0.0055 | 0.648 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0082 | 1 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0082 | 1 | 1 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0082 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0082 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0082 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0082 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of purified full-length human PASK expressed in insect cells using MBP protein substrate incubated for 10 mins before ATP addition and measured after 1 hr by kinase-Glo luminescent kinase assay | ChEMBL. | No reference | |
IC50 (binding) | <= 10 uM | Inhibition of purified human PASK kinase domain expressed in insect cells using MBP protein substrate incubated for 10 mins before ATP addition and measured after 1 hr by kinase-Glo luminescent kinase assay | ChEMBL. | No reference |
IC50 (binding) | <= 10 uM | Inhibition of GST-tagged full-length purified human CK2a2 using RRRDDDSDDD substrate incubated for 120 mins in presence of [33P]ATP by scintillation counting based biochemical assay | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.