Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | PAS domain containing serine/threonine kinase | No references | |
Homo sapiens | casein kinase 2, alpha prime polypeptide | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | casein kinase II, alpha chain, putative | casein kinase 2, alpha prime polypeptide | 350 aa | 319 aa | 50.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase domain containing protein | 0.0082 | 1 | 0.5 |
Plasmodium falciparum | casein kinase 2, alpha subunit | 0.0082 | 1 | 0.5 |
Onchocerca volvulus | 0.0055 | 0.648 | 0.5 | |
Entamoeba histolytica | casein kinase, putative | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Plasmodium vivax | casein kinase 2, alpha subunit, putative | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Plasmodium vivax | unspecified product | 0.0082 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0082 | 1 | 0.5 |
Leishmania major | casein kinase II, putative | 0.0082 | 1 | 0.5 |
Trypanosoma brucei | Casein kinase II | 0.0082 | 1 | 1 |
Echinococcus multilocularis | casein kinase ii subunit alpha | 0.0082 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0082 | 1 | 1 |
Trypanosoma cruzi | casein kinase II, putative | 0.0082 | 1 | 0.5 |
Toxoplasma gondii | CMGC kinase, CK2 family | 0.0082 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0082 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0082 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of purified full-length human PASK expressed in insect cells using MBP protein substrate incubated for 10 mins before ATP addition and measured after 1 hr by kinase-Glo luminescent kinase assay | ChEMBL. | No reference | |
IC50 (binding) | <= 10 uM | Inhibition of purified human PASK kinase domain expressed in insect cells using MBP protein substrate incubated for 10 mins before ATP addition and measured after 1 hr by kinase-Glo luminescent kinase assay | ChEMBL. | No reference |
IC50 (binding) | <= 10 uM | Inhibition of GST-tagged full-length purified human CK2a2 using RRRDDDSDDD substrate incubated for 120 mins in presence of [33P]ATP by scintillation counting based biochemical assay | PATENT. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.